An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

Lymphatic endothelial cells (LECs) of the lymph node (LN) parenchyma orchestrate leukocyte trafficking and peripheral T cell dynamics. T cell responses to immunotherapy largely rely on peripheral T cell recruitment in tumors. Yet, a systematic and molecular understanding of how LECs within the LNs c...

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Vydáno v:	Cell reports (Cambridge) Ročník 43; číslo 4; s. 114020
Hlavní autoři:	Houbaert, Diede, Nikolakopoulos, Apostolos Panagiotis, Jacobs, Kathryn A., Meçe, Odeta, Roels, Jana, Shankar, Gautam, Agrawal, Madhur, More, Sanket, Ganne, Maarten, Rillaerts, Kristine, Boon, Louis, Swoboda, Magdalena, Nobis, Max, Mourao, Larissa, Bosisio, Francesca, Vandamme, Niels, Bergers, Gabriele, Scheele, Colinda L.G.J., Agostinis, Patrizia
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 23.04.2024 Elsevier
Témata:	Animals autophagy Autophagy - drug effects Autophagy-Related Protein 5 - genetics Autophagy-Related Protein 5 - metabolism cancer Cell Movement CP: Cancer CP: Immunology Endothelial Cells - metabolism Humans Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use immunotherapy Immunotherapy - methods lymph node Lymph Nodes - immunology lymphatic endothelial cells Lysophospholipids - metabolism Mice Mice, Inbred C57BL Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine - pharmacology T cell trafficking T-Lymphocytes - immunology T-Lymphocytes - metabolism CP: Immunology autophagy lymph node CP: Cancer immunotherapy lymphatic endothelial cells cancer T cell trafficking
ISSN:	2211-1247, 2211-1247
On-line přístup:	Získat plný text
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