An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

Lymphatic endothelial cells (LECs) of the lymph node (LN) parenchyma orchestrate leukocyte trafficking and peripheral T cell dynamics. T cell responses to immunotherapy largely rely on peripheral T cell recruitment in tumors. Yet, a systematic and molecular understanding of how LECs within the LNs c...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 43; no. 4; p. 114020
Main Authors:	Houbaert, Diede, Nikolakopoulos, Apostolos Panagiotis, Jacobs, Kathryn A., Meçe, Odeta, Roels, Jana, Shankar, Gautam, Agrawal, Madhur, More, Sanket, Ganne, Maarten, Rillaerts, Kristine, Boon, Louis, Swoboda, Magdalena, Nobis, Max, Mourao, Larissa, Bosisio, Francesca, Vandamme, Niels, Bergers, Gabriele, Scheele, Colinda L.G.J., Agostinis, Patrizia
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 23.04.2024 Elsevier
Subjects:	Animals autophagy Autophagy - drug effects Autophagy-Related Protein 5 - genetics Autophagy-Related Protein 5 - metabolism cancer Cell Movement CP: Cancer CP: Immunology Endothelial Cells - metabolism Humans Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use immunotherapy Immunotherapy - methods lymph node Lymph Nodes - immunology lymphatic endothelial cells Lysophospholipids - metabolism Mice Mice, Inbred C57BL Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine - pharmacology T cell trafficking T-Lymphocytes - immunology T-Lymphocytes - metabolism CP: Immunology autophagy lymph node CP: Cancer immunotherapy lymphatic endothelial cells cancer T cell trafficking
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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