Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans

T cell exhaustion is an induced state of dysfunction that arises in response to chronic infection and cancer. Exhausted CD8 + T cells acquire a distinct epigenetic state, but it is not known whether that chromatin landscape is fixed or plastic following the resolution of a chronic infection. Here we...

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Bibliographic Details
Published in:	Nature immunology Vol. 22; no. 8; pp. 1020 - 1029
Main Authors:	Yates, Kathleen B., Tonnerre, Pierre, Martin, Genevieve E., Gerdemann, Ulrike, Al Abosy, Rose, Comstock, Dawn E., Weiss, Sarah A., Wolski, David, Tully, Damien C., Chung, Raymond T., Allen, Todd M., Kim, Arthur Y., Fidler, Sarah, Fox, Julie, Frater, John, Lauer, Georg M., Haining, W. Nicholas, Sen, Debattama R.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.08.2021 Nature Publishing Group
Subjects:	2-Naphthylamine - therapeutic use 631/1647/2210/2211 631/250/255/1901 631/250/255/234/2513/1551 692/420/2780/2152/1566/2493 Anilides - therapeutic use Antigens Antigens, Viral - immunology Antiviral Agents - therapeutic use Biomedical and Life Sciences Biomedicine CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Chromatin Chromatin - metabolism Chronic infection Cyclopropanes - therapeutic use Enhancers Epigenesis, Genetic - genetics Epigenetics Hepacivirus - drug effects Hepacivirus - immunology Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology High Mobility Group Proteins - genetics HIV Human immunodeficiency virus Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Immunologic Memory - immunology Immunology Infections Infectious Diseases Inflammation Lactams, Macrocyclic - therapeutic use Lymphocytes Lymphocytes T Plasticity Proline - analogs & derivatives Proline - therapeutic use Ribavirin - therapeutic use Ritonavir - therapeutic use Sulfonamides - therapeutic use Uracil - analogs & derivatives Uracil - therapeutic use Valine - therapeutic use
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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