Development and validation of a targeted gene sequencing panel for application to disparate cancers

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology treatments based on a tumour’s molecular profile. We aimed to develop a targeted gene sequencing panel for application to disparate cancer types with particular focus on...

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Veröffentlicht in:	Scientific reports Jg. 9; H. 1; S. 17052 - 16
Hauptverfasser:	McCabe, Mark J., Gauthier, Marie-Emilie A., Chan, Chia-Ling, Thompson, Tanya J., De Sousa, Sunita M.C., Puttick, Clare, Grady, John P., Gayevskiy, Velimir, Tao, Jiang, Ying, Kevin, Cipponi, Arcadi, Deng, Niantao, Swarbrick, Alex, Thomas, Melissa L., Lord, Reginald V., Johns, Amber L., Kohonen-Corish, Maija, O’Toole, Sandra A., Clark, Jonathan, Mueller, Simon A., Gupta, Ruta, McCormack, Ann I., Dinger, Marcel E., Cowley, Mark J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 19.11.2019 Nature Publishing Group
Schlagworte:	45/23 45/41 45/47 631/208/514/2254 631/67/69 692/4028/67/69 Bioinformatics Biomarkers, Tumor - genetics Biopsy Cancer Carcinoma, Pancreatic Ductal - genetics Cell Line, Tumor Circulating Tumor DNA - genetics Computational Biology - methods Deoxyribonucleic acid DNA DNA sequencing Gene frequency Genetic Predisposition to Disease - genetics Genetic testing Genomics - methods Head & neck cancer Head and Neck Neoplasms - genetics High-Throughput Nucleotide Sequencing - methods Humanities and Social Sciences Humans Liquid Biopsy multidisciplinary Next-generation sequencing Oncology Pancreatic Neoplasms - genetics Pituitary Neoplasms - genetics Precision medicine Precision Medicine - methods Science Science (multidisciplinary) Sensitivity and Specificity Squamous Cell Carcinoma of Head and Neck - genetics Tumors
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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