Neurological update: use of cardiac troponin in patients with stroke

Cardiac troponin is a specific and sensitive biomarker to identify and quantify myocardial injury. Myocardial injury is frequently detected after acute ischemic stroke and strongly associated with unfavorable outcomes. Concomitant acute coronary syndrome is only one of several possible differential...

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Bibliographic Details
Published in:Journal of neurology Vol. 268; no. 6; pp. 2284 - 2292
Main Authors: Scheitz, Jan F., Stengl, Helena, Nolte, Christian H., Landmesser, Ulf, Endres, Matthias
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2021
Springer Nature B.V
Subjects:
Acute Coronary Syndrome
Arrhythmia
Autonomic nervous system
Biomarkers
Brain Ischemia - complications
Calcium-binding protein
Humans
Ischemia
Medicine
Medicine & Public Health
Neurological Update
Neurology
Neuroradiology
Neurosciences
Stroke
Stroke - complications
Troponin
Cardiac biomarker
Myocardial infarction
Brain–heart interaction
Cardiac troponin
Ischemic stroke
Stroke-heart-syndrome
Myocardial injury
ISSN:0340-5354, 1432-1459, 1432-1459
Online Access:Get full text
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Summary:Cardiac troponin is a specific and sensitive biomarker to identify and quantify myocardial injury. Myocardial injury is frequently detected after acute ischemic stroke and strongly associated with unfavorable outcomes. Concomitant acute coronary syndrome is only one of several possible differential diagnoses that may cause elevation of cardiac troponin after stroke. As a result, there are uncertainties regarding the correct interpretation and optimal management of stroke patients with myocardial injury in clinical practice. Elevation of cardiac troponin may occur as part of a ‘Stroke-Heart Syndrome’. The term ‘Stroke-Heart Syndrome’ subsumes a clinical spectrum of cardiac complications after stroke including cardiac injury, dysfunction, and arrhythmia which may relate to disturbances of autonomic function and the brain–heart axis. In this review, we provide an up-to-date overview about prognostic implications, mechanisms, and management of elevated cardiac troponin levels in patients with acute ischemic stroke.
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ISSN:0340-5354
1432-1459
1432-1459
DOI:10.1007/s00415-020-10349-w