Harmonic motion imaging of human breast masses: an in vivo clinical feasibility

Non-invasive diagnosis of breast cancer is still challenging due to the low specificity of the imaging modalities that calls for unnecessary biopsies. The diagnostic accuracy can be improved by assessing the breast tissue mechanical properties associated with pathological changes. Harmonic motion im...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Scientific reports Ročník 10; číslo 1; s. 15254
Hlavní autori:	Saharkhiz, Niloufar, Ha, Richard, Taback, Bret, Li, Xiaoyue Judy, Weber, Rachel, Nabavizadeh, Alireza, Lee, Stephen A., Hibshoosh, Hanina, Gatti, Vittorio, Kamimura, Hermes A. S., Konofagou, Elisa E.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 17.09.2020 Nature Publishing Group
Predmet:	631/1647/245/1859 631/67/1347 639/166/985 692/308/575 692/699/67/1347 Biopsy Breast - diagnostic imaging Breast cancer Breast Neoplasms - diagnostic imaging Elastic properties Elasticity Imaging Techniques - methods Feasibility Studies Female High-Intensity Focused Ultrasound Ablation - methods Histology Humanities and Social Sciences Humans Mechanical properties Middle Aged Motion multidisciplinary Nonlinear systems Science Science (multidisciplinary) Tissues Transducers Tumors
ISSN:	2045-2322, 2045-2322
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Non-invasive diagnosis of breast cancer is still challenging due to the low specificity of the imaging modalities that calls for unnecessary biopsies. The diagnostic accuracy can be improved by assessing the breast tissue mechanical properties associated with pathological changes. Harmonic motion imaging (HMI) is an elasticity imaging technique that uses acoustic radiation force to evaluate the localized mechanical properties of the underlying tissue. Herein, we studied the in vivo feasibility of a clinical HMI system to differentiate breast tumors based on their relative HMI displacements, in human subjects. We performed HMI scans in 10 female subjects with breast masses: five benign and five malignant masses. Results revealed that both benign and malignant masses were stiffer than the surrounding tissues. However, malignant tumors underwent lower mean HMI displacement (1.1 ± 0.5 µm) compared to benign tumors (3.6 ± 1.5 µm) and the adjacent non-cancerous tissue (6.4 ± 2.5 µm), which allowed to differentiate between tumor types. Additionally, the excised breast specimens of the same patients (n = 5) were imaged post-surgically, where there was an excellent agreement between the in vivo and ex vivo findings, confirmed with histology. Higher displacement contrast between cancerous and non-cancerous tissue was found ex vivo, potentially due to the lower nonlinearity in the elastic properties of ex vivo tissue. This preliminary study lays the foundation for the potential complementary application of HMI in clinical practice in conjunction with the B-mode to classify suspicious breast masses.
AbstractList	Non-invasive diagnosis of breast cancer is still challenging due to the low specificity of the imaging modalities that calls for unnecessary biopsies. The diagnostic accuracy can be improved by assessing the breast tissue mechanical properties associated with pathological changes. Harmonic motion imaging (HMI) is an elasticity imaging technique that uses acoustic radiation force to evaluate the localized mechanical properties of the underlying tissue. Herein, we studied the in vivo feasibility of a clinical HMI system to differentiate breast tumors based on their relative HMI displacements, in human subjects. We performed HMI scans in 10 female subjects with breast masses: five benign and five malignant masses. Results revealed that both benign and malignant masses were stiffer than the surrounding tissues. However, malignant tumors underwent lower mean HMI displacement (1.1 ± 0.5 µm) compared to benign tumors (3.6 ± 1.5 µm) and the adjacent non-cancerous tissue (6.4 ± 2.5 µm), which allowed to differentiate between tumor types. Additionally, the excised breast specimens of the same patients (n = 5) were imaged post-surgically, where there was an excellent agreement between the in vivo and ex vivo findings, confirmed with histology. Higher displacement contrast between cancerous and non-cancerous tissue was found ex vivo, potentially due to the lower nonlinearity in the elastic properties of ex vivo tissue. This preliminary study lays the foundation for the potential complementary application of HMI in clinical practice in conjunction with the B-mode to classify suspicious breast masses. Non-invasive diagnosis of breast cancer is still challenging due to the low specificity of the imaging modalities that calls for unnecessary biopsies. The diagnostic accuracy can be improved by assessing the breast tissue mechanical properties associated with pathological changes. Harmonic motion imaging (HMI) is an elasticity imaging technique that uses acoustic radiation force to evaluate the localized mechanical properties of the underlying tissue. Herein, we studied the in vivo feasibility of a clinical HMI system to differentiate breast tumors based on their relative HMI displacements, in human subjects. We performed HMI scans in 10 female subjects with breast masses: five benign and five malignant masses. Results revealed that both benign and malignant masses were stiffer than the surrounding tissues. However, malignant tumors underwent lower mean HMI displacement (1.1 ± 0.5 µm) compared to benign tumors (3.6 ± 1.5 µm) and the adjacent non-cancerous tissue (6.4 ± 2.5 µm), which allowed to differentiate between tumor types. Additionally, the excised breast specimens of the same patients (n = 5) were imaged post-surgically, where there was an excellent agreement between the in vivo and ex vivo findings, confirmed with histology. Higher displacement contrast between cancerous and non-cancerous tissue was found ex vivo, potentially due to the lower nonlinearity in the elastic properties of ex vivo tissue. This preliminary study lays the foundation for the potential complementary application of HMI in clinical practice in conjunction with the B-mode to classify suspicious breast masses.Non-invasive diagnosis of breast cancer is still challenging due to the low specificity of the imaging modalities that calls for unnecessary biopsies. The diagnostic accuracy can be improved by assessing the breast tissue mechanical properties associated with pathological changes. Harmonic motion imaging (HMI) is an elasticity imaging technique that uses acoustic radiation force to evaluate the localized mechanical properties of the underlying tissue. Herein, we studied the in vivo feasibility of a clinical HMI system to differentiate breast tumors based on their relative HMI displacements, in human subjects. We performed HMI scans in 10 female subjects with breast masses: five benign and five malignant masses. Results revealed that both benign and malignant masses were stiffer than the surrounding tissues. However, malignant tumors underwent lower mean HMI displacement (1.1 ± 0.5 µm) compared to benign tumors (3.6 ± 1.5 µm) and the adjacent non-cancerous tissue (6.4 ± 2.5 µm), which allowed to differentiate between tumor types. Additionally, the excised breast specimens of the same patients (n = 5) were imaged post-surgically, where there was an excellent agreement between the in vivo and ex vivo findings, confirmed with histology. Higher displacement contrast between cancerous and non-cancerous tissue was found ex vivo, potentially due to the lower nonlinearity in the elastic properties of ex vivo tissue. This preliminary study lays the foundation for the potential complementary application of HMI in clinical practice in conjunction with the B-mode to classify suspicious breast masses. Non-invasive diagnosis of breast cancer is still challenging due to the low specificity of the imaging modalities that calls for unnecessary biopsies. The diagnostic accuracy can be improved by assessing the breast tissue mechanical properties associated with pathological changes. Harmonic motion imaging (HMI) is an elasticity imaging technique that uses acoustic radiation force to evaluate the localized mechanical properties of the underlying tissue. Herein, we studied the in vivo feasibility of a clinical HMI system to differentiate breast tumors based on their relative HMI displacements, in human subjects. We performed HMI scans in 10 female subjects with breast masses: five benign and five malignant masses. Results revealed that both benign and malignant masses were stiffer than the surrounding tissues. However, malignant tumors underwent lower mean HMI displacement (1.1 ± 0.5 µm) compared to benign tumors (3.6 ± 1.5 µm) and the adjacent non-cancerous tissue (6.4 ± 2.5 µm), which allowed to differentiate between tumor types. Additionally, the excised breast specimens of the same patients (n = 5) were imaged post-surgically, where there was an excellent agreement between the in vivo and ex vivo findings, confirmed with histology. Higher displacement contrast between cancerous and non-cancerous tissue was found ex vivo, potentially due to the lower nonlinearity in the elastic properties of ex vivo tissue. This preliminary study lays the foundation for the potential complementary application of HMI in clinical practice in conjunction with the B-mode to classify suspicious breast masses.
ArticleNumber	15254
Author	Saharkhiz, Niloufar Taback, Bret Ha, Richard Hibshoosh, Hanina Kamimura, Hermes A. S. Konofagou, Elisa E. Li, Xiaoyue Judy Gatti, Vittorio Nabavizadeh, Alireza Lee, Stephen A. Weber, Rachel
Author_xml	– sequence: 1 givenname: Niloufar surname: Saharkhiz fullname: Saharkhiz, Niloufar organization: Department of Biomedical Engineering, Columbia University – sequence: 2 givenname: Richard surname: Ha fullname: Ha, Richard organization: Department of Radiology, New-York-Presbyterian/Columbia University Medical Center – sequence: 3 givenname: Bret surname: Taback fullname: Taback, Bret organization: Department of Surgery, New-York-Presbyterian/Columbia University Medical Center – sequence: 4 givenname: Xiaoyue Judy surname: Li fullname: Li, Xiaoyue Judy organization: Department of Biomedical Engineering, Columbia University – sequence: 5 givenname: Rachel surname: Weber fullname: Weber, Rachel organization: Department of Biomedical Engineering, Columbia University – sequence: 6 givenname: Alireza surname: Nabavizadeh fullname: Nabavizadeh, Alireza organization: Department of Biomedical Engineering, Columbia University – sequence: 7 givenname: Stephen A. surname: Lee fullname: Lee, Stephen A. organization: Department of Biomedical Engineering, Columbia University – sequence: 8 givenname: Hanina surname: Hibshoosh fullname: Hibshoosh, Hanina organization: Department of Pathology and Cell Biology, New-York-Presbyterian/Columbia University Medical Center – sequence: 9 givenname: Vittorio surname: Gatti fullname: Gatti, Vittorio organization: Department of Biomedical Engineering, Columbia University – sequence: 10 givenname: Hermes A. S. surname: Kamimura fullname: Kamimura, Hermes A. S. organization: Department of Biomedical Engineering, Columbia University – sequence: 11 givenname: Elisa E. surname: Konofagou fullname: Konofagou, Elisa E. email: ek2191@columbia.edu organization: Department of Biomedical Engineering, Columbia University, Department of Radiology, New-York-Presbyterian/Columbia University Medical Center
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32943648$$D View this record in MEDLINE/PubMed
BookMark	eNp9kTtPBCEUhYnR-P4DFobExmaU94CFiTG-EpNttCYMy6yYGVCY2cR_L-vq-iik4Qa-c7iXswPWQwwOgAOMTjCi8jQzzJWsEEFVjZVAFV8D2wQxXhFKyPqPegvs5_yMyuJEMaw2wRYtBRVMboPJrUl9DN7CPg4-Buh7M_NhBmMLn8beBNgkZ_IAe5Ozy2ewnPgA534eoe18EZoOtoXwje_88LYHNlrTZbf_ue-Cx-urh8vb6n5yc3d5cV9ZVrOhYjXBojG1Uy2SnEkyRcIyzLjFBjsuzJSQxhqOqWtrUlurDBdUtYpKxGXT0l1wvvR9GZveTa0LQzKdfkml__Smo_H6903wT3oW57pmSjKBi8Hxp0GKr6PLg-59tq7rTHBxzJowxqjElImCHv1Bn-OYQhlPE6G4REjVvFCHPztatfL11wUgS8CmmHNy7QrBSC8y1ctMdclUf2SqF67yj8j6wSySKlP57n8pXUpzeSfMXPpu-x_VO_ICtSM
CitedBy_id	crossref_primary_10_1109_TBME_2022_3211465 crossref_primary_10_1016_j_ultrasmedbio_2024_09_021 crossref_primary_10_1109_TMI_2021_3055779 crossref_primary_10_1016_j_ultrasmedbio_2023_03_025 crossref_primary_10_1109_TMI_2022_3178897 crossref_primary_10_1088_1361_6560_abddd1 crossref_primary_10_1109_TUFFC_2023_3329729 crossref_primary_10_1146_annurev_bioeng_103023_111151 crossref_primary_10_1016_j_ultrasmedbio_2023_09_012
Cites_doi	10.1158/1078-0432.CCR-18-3669 10.1177/016173460602800302 10.6061/clinics/2013(04)05 10.1186/s13058-016-0707-3 10.1109/TUFFC.2015.007113 10.1016/j.rcl.2014.01.002 10.1148/radiology.196.1.7784555 10.1016/j.crad.2015.10.029 10.1007/s12282-011-0326-x 10.1109/TUFFC.2012.2343 10.1148/radiol.2391041676 10.1088/0031-9155/49/18/014 10.1109/TUFFC.2010.1554 10.1148/radiology.207.1.9530316 10.1001/jama.299.18.2151 10.1088/0031-9155/60/7/2853 10.5114/pjr.2019.86852 10.1126/science.280.5360.82 10.1016/S0140-6736(85)92204-4 10.1148/radiol.2442060461 10.1038/nrc1041 10.1016/S0301-5629(03)00953-0 10.7863/jum.2012.31.6.895 10.1056/NEJMoa052911 10.3322/caac.21551 10.1148/radiol.2213010364 10.1121/1.1378344 10.7150/thno.37965 10.1109/TUFFC.2004.1295425 10.1056/NEJMoa062790 10.1177/016173469101300201 10.1109/TMI.2012.2205586 10.1016/j.ultrasmedbio.2005.08.008 10.1016/j.apacoust.2017.05.022 10.1007/s11547-017-0805-z 10.1109/TUFFC.2017.2781188 10.2214/AJR.13.12072 10.1016/j.ultrasmedbio.2015.03.009 10.1088/1361-6560/aa6024 10.1007/978-1-4615-1943-0_23 10.1148/radiology.213.3.r99dc20889 10.1371/journal.pone.0119398 10.1016/0301-5629(95)02005-5 10.1016/j.jacr.2017.11.034 10.1002/mp.13170 10.1007/s00330-013-2854-6 10.1073/pnas.96.12.6603 10.1088/0031-9155/52/6/002 10.7916/D8KS83H7 10.1016/S0301-5629(98)00110-0 10.1002/1097-0142(19950815)76:4<626::AID-CNCR2820760413>3.0.CO;2-Z 10.1148/radiology.214.1.r00ja2559 10.3322/canjclin.57.2.75 10.1148/radiol.2251011667 10.1093/jnci/djv367 10.1016/j.ultrasmedbio.2003.07.001 10.1113/jphysiol.1954.sp005099 10.1016/j.ultrasmedbio.2003.08.008 10.1109/TUFFC.2013.2617 10.1186/bcr764 10.1016/S0033-8389(22)00643-1 10.1109/ULTSYM.2018.8579993 10.1109/ULTSYM.2017.8091551
ContentType	Journal Article
Copyright	This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020 This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020 – notice: This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM
DOI	10.1038/s41598-020-71960-5
DatabaseName	Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database (ProQuest) ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	CrossRef MEDLINE - Academic MEDLINE Publicly Available Content Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2045-2322
ExternalDocumentID	PMC7498461 32943648 10_1038_s41598_020_71960_5
Genre	Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: National Institutes of Health grantid: R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275 – fundername: NIH HHS grantid: R01CA228275 – fundername: NCI NIH HHS grantid: R01 CA228275 – fundername: ; grantid: R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275; R01CA228275
GroupedDBID	0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFFHD AFPKN CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7XB 8FK K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c474t-47216ba7e9f085482d06c4145c1a1e56ad22bca513ef727cc9a5639f938058bf3
IEDL.DBID	M7P
ISICitedReferencesCount	14
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000573742900028&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2045-2322
IngestDate	Tue Nov 04 01:57:40 EST 2025 Thu Oct 02 05:20:51 EDT 2025 Tue Oct 07 09:19:55 EDT 2025 Mon Jul 21 06:05:08 EDT 2025 Sat Nov 29 04:02:27 EST 2025 Tue Nov 18 19:52:40 EST 2025 Fri Feb 21 02:38:56 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c474t-47216ba7e9f085482d06c4145c1a1e56ad22bca513ef727cc9a5639f938058bf3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://www.proquest.com/docview/2695800975?pq-origsite=%requestingapplication%
PMID	32943648
PQID	2695800975
PQPubID	2041939
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_7498461 proquest_miscellaneous_2444381346 proquest_journals_2695800975 pubmed_primary_32943648 crossref_primary_10_1038_s41598_020_71960_5 crossref_citationtrail_10_1038_s41598_020_71960_5 springer_journals_10_1038_s41598_020_71960_5
PublicationCentury	2000
PublicationDate	2020-09-17
PublicationDateYYYYMMDD	2020-09-17
PublicationDate_xml	– month: 09 year: 2020 text: 2020-09-17 day: 17
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Scientific reports
PublicationTitleAbbrev	Sci Rep
PublicationTitleAlternate	Sci Rep
PublicationYear	2020
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Ophir, Céspedes, Ponnekanti, Yazdi (CR26) 1991; 13 Yoon, Jung, Lee, Ko (CR35) 2013; 23 Han, Wang, Payen, Konofagou (CR50) 2017; 62 Etzioni (CR2) 2003; 3 Zanotel (CR21) 2018; 123 Berg (CR18) 2008; 299 Rahbar (CR12) 1999; 213 Samani, Plewes (CR57) 2004; 49 Shiina (CR53) 2015; 41 Shapiro, Venet, Strax, Venet, Roeser (CR3) 1982; 69 Stavros (CR11) 1995; 196 Song (CR34) 2012; 31 Nabavizadeh (CR59) 2020; 10 Wade (CR63) 1954; 124 Denis (CR52) 2015; 10 Nightingale, Palmeri, Trahey (CR66) 2006; 32 Tabár (CR4) 1985; 1 Nightingale, Palmeri, Nightingale, Trahey (CR30) 2001; 110 Berg (CR19) 2016; 108 Elseedawy, Whelehan, Vinnicombe, Thomson, Evans (CR56) 2016; 71 Maleke, Pernot, Konofagou (CR43) 2006; 28 Toprak, Yokus, Gündüz, Akdenız (CR36) 2019; 84 Boyd (CR6) 2007; 356 Sarvazyan, Rudenko, Swanson, Fowlkes, Emelianov (CR29) 1998; 24 CR45 Nabavizadeh (CR58) 2018; 45 Siegel, Miller, Jemal (CR1) 2019; 69 Gordon, Goldenberg (CR14) 1995; 76 Fatemi, Greenleaf (CR38) 1999; 96 Nightingale, McAleavey, Trahey (CR32) 2003; 29 Chen (CR46) 2015; 62 Han, Wang, Hibshoosh, Taback, Konofagou (CR48) 2016; 18 Pisano (CR7) 2005; 353 Sewell (CR24) 1995; 33 Itoh (CR28) 2006; 239 Samani, Zubovits, Plewes (CR22) 2007; 52 Fatemi, Greenleaf (CR37) 1998; 280 Bercoff, Tanter, Fink (CR33) 2004; 51 Sharma, Soo, Trahey, Nightingale (CR31) 2004; 1 Payen (CR44) 2020; 26 Baggio, Kamimura, Henrique Lopes, Carneiro, Silva (CR42) 2017; 126 Barr, Zhang (CR62) 2012; 31 Monticciolo (CR10) 2018; 15 Kaplan (CR20) 2014; 52 Sandrin (CR25) 2003; 29 CR55 Saslow (CR8) 2007; 57 Brem, Lenihan, Lieberman, Torrente (CR17) 2015; 204 Jianwen Luo, Konofagou (CR65) 2010; 57 Han, Payen, Wang, Konofagou (CR60) 2018; 65 Kamimura (CR39) 2013; 68 Vappou (CR47) 2015; 60 Sarvazyan (CR23) 1995 Han (CR49) 2018 Konofagou, Hynynen (CR41) 2003; 29 Kamimura, Urban, Carneiro, Fatemi, Alizad (CR40) 2012; 59 Berg, Gilbreath (CR15) 2000; 214 Lehman (CR9) 2007; 244 Kaplan (CR16) 2001; 221 Doherty, Trahey, Nightingale, Palmeri (CR27) 2013; 60 CR64 Kolb, Lichy, Newhouse (CR13) 1998; 207 Kolb, Lichy, Newhouse (CR5) 2002; 225 Stavros, Rapp, Parker (CR61) 2004 Chen, Adler, Carson, Jenkins, O’Brien (CR54) 1995; 21 Nakashima, Moriya (CR51) 2013; 20 K Nightingale (71960_CR32) 2003; 29 Y Han (71960_CR48) 2016; 18 Y Han (71960_CR49) 2018 71960_CR64 L Sandrin (71960_CR25) 2003; 29 Y Han (71960_CR60) 2018; 65 L Tabár (71960_CR4) 1985; 1 J Vappou (71960_CR47) 2015; 60 M Fatemi (71960_CR37) 1998; 280 A Itoh (71960_CR28) 2006; 239 M Fatemi (71960_CR38) 1999; 96 A Nabavizadeh (71960_CR58) 2018; 45 R Etzioni (71960_CR2) 2003; 3 HAS Kamimura (71960_CR39) 2013; 68 RG Barr (71960_CR62) 2012; 31 AT Stavros (71960_CR11) 1995; 196 EE Konofagou (71960_CR41) 2003; 29 JH Yoon (71960_CR35) 2013; 23 KR Nightingale (71960_CR30) 2001; 110 TM Kolb (71960_CR5) 2002; 225 T Payen (71960_CR44) 2020; 26 SS Kaplan (71960_CR20) 2014; 52 HAS Kamimura (71960_CR40) 2012; 59 M Elseedawy (71960_CR56) 2016; 71 WA Berg (71960_CR15) 2000; 214 M Zanotel (71960_CR21) 2018; 123 A Samani (71960_CR22) 2007; 52 TM Kolb (71960_CR13) 1998; 207 SS Kaplan (71960_CR16) 2001; 221 ED Pisano (71960_CR7) 2005; 353 JR Doherty (71960_CR27) 2013; 60 H Chen (71960_CR46) 2015; 62 PB Gordon (71960_CR14) 1995; 76 P Song (71960_CR34) 2012; 31 71960_CR45 WA Berg (71960_CR19) 2016; 108 AP Sarvazyan (71960_CR29) 1998; 24 T Shiina (71960_CR53) 2015; 41 J Ophir (71960_CR26) 1991; 13 S Shapiro (71960_CR3) 1982; 69 AL Baggio (71960_CR42) 2017; 126 DL Monticciolo (71960_CR10) 2018; 15 G Rahbar (71960_CR12) 1999; 213 K Nakashima (71960_CR51) 2013; 20 NF Boyd (71960_CR6) 2007; 356 M Denis (71960_CR52) 2015; 10 A Samani (71960_CR57) 2004; 49 N Toprak (71960_CR36) 2019; 84 D Saslow (71960_CR8) 2007; 57 AP Sarvazyan (71960_CR23) 1995 71960_CR55 RF Brem (71960_CR17) 2015; 204 AT Stavros (71960_CR61) 2004 OL Wade (71960_CR63) 1954; 124 WA Berg (71960_CR18) 2008; 299 C Maleke (71960_CR43) 2006; 28 Y Han (71960_CR50) 2017; 62 CD Lehman (71960_CR9) 2007; 244 J Jianwen Luo (71960_CR65) 2010; 57 J Bercoff (71960_CR33) 2004; 51 CW Sewell (71960_CR24) 1995; 33 RL Siegel (71960_CR1) 2019; 69 EJ Chen (71960_CR54) 1995; 21 A Nabavizadeh (71960_CR59) 2020; 10 K Nightingale (71960_CR66) 2006; 32 AC Sharma (71960_CR31) 2004; 1
References_xml	– ident: CR45 – year: 2004 ident: CR61 publication-title: Breast ultrasound – volume: 26 start-page: 1297 year: 2020 end-page: 1308 ident: CR44 article-title: Harmonic motion imaging of pancreatic tumor stiffness indicates disease state and treatment response publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-18-3669 – volume: 28 start-page: 144 year: 2006 end-page: 158 ident: CR43 article-title: Single-element focused ultrasound transducer method for harmonic motion imaging publication-title: Ultrason. Imaging doi: 10.1177/016173460602800302 – volume: 68 start-page: 463 year: 2013 end-page: 468 ident: CR39 article-title: Vibroacoustography for the assessment of total hip arthroplasty publication-title: Clinics doi: 10.6061/clinics/2013(04)05 – volume: 18 start-page: 46 year: 2016 ident: CR48 article-title: Tumor characterization and treatment monitoring of postsurgical human breast specimens using harmonic motion imaging (HMI) publication-title: Breast Cancer Res. doi: 10.1186/s13058-016-0707-3 – volume: 1 start-page: 728 year: 2004 end-page: 731 ident: CR31 article-title: Acoustic radiation force impulse imaging of in vivo breast masses publication-title: IEEE Ultrason. Symp. – volume: 62 start-page: 1662 year: 2015 end-page: 1673 ident: CR46 article-title: Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: An in vivo feasibility study in a transgenic mouse model of pancreatic cancer publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2015.007113 – volume: 52 start-page: 539 year: 2014 end-page: 546 ident: CR20 article-title: Automated whole breast ultrasound publication-title: Radiol. Clin. N. Am. doi: 10.1016/j.rcl.2014.01.002 – volume: 196 start-page: 123 year: 1995 end-page: 134 ident: CR11 article-title: Solid breast nodules: use of sonography to distinguish between benign and malignant lesions publication-title: Radiology doi: 10.1148/radiology.196.1.7784555 – volume: 71 start-page: 92 year: 2016 end-page: 95 ident: CR56 article-title: Factors influencing the stiffness of fibroadenomas at shear wave elastography publication-title: Clin. Radiol. doi: 10.1016/j.crad.2015.10.029 – volume: 20 start-page: 3 year: 2013 end-page: 12 ident: CR51 article-title: Comprehensive ultrasound diagnosis for intraductal spread of primary breast cancer publication-title: Breast Cancer doi: 10.1007/s12282-011-0326-x – volume: 59 start-page: 1421 year: 2012 end-page: 1431 ident: CR40 article-title: Vibro-acoustography beam formation with reconfigurable arrays publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2012.2343 – volume: 239 start-page: 341 year: 2006 end-page: 350 ident: CR28 article-title: Breast disease: clinical application of US elastography for diagnosis publication-title: Radiology doi: 10.1148/radiol.2391041676 – volume: 49 start-page: 4395 year: 2004 end-page: 4405 ident: CR57 article-title: A method to measure the hyperelastic parameters of ex vivo breast tissue samples publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/49/18/014 – volume: 57 start-page: 1347 year: 2010 end-page: 1357 ident: CR65 article-title: A fast normalized cross-correlation calculation method for motion estimation publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2010.1554 – volume: 207 start-page: 191 year: 1998 end-page: 199 ident: CR13 article-title: Occult cancer in women with dense breasts: detection with screening US–diagnostic yield and tumor characteristics publication-title: Radiology doi: 10.1148/radiology.207.1.9530316 – volume: 299 start-page: 2151 year: 2008 end-page: 2163 ident: CR18 article-title: Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer publication-title: JAMA J. Am. Med. Assoc. doi: 10.1001/jama.299.18.2151 – volume: 60 start-page: 2853 year: 2015 end-page: 2868 ident: CR47 article-title: Non-contact, ultrasound-based indentation method for measuring elastic properties of biological tissues using Harmonic Motion Imaging (HMI) publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/60/7/2853 – volume: 84 start-page: 224 year: 2019 end-page: 233 ident: CR36 article-title: Histopathology and elastography discordance in evaluation of breast lesions with acoustic radiation force impulse elastography publication-title: Polish J. Radiol. doi: 10.5114/pjr.2019.86852 – volume: 280 start-page: 82 year: 1998 end-page: 85 ident: CR37 article-title: Ultrasound-stimulated vibro-acoustic spectrography publication-title: Science doi: 10.1126/science.280.5360.82 – volume: 1 start-page: 829 year: 1985 end-page: 832 ident: CR4 article-title: Reduction in mortality from breast cancer after mass screening with mammography. Randomised trial from the breast cancer screening working group of the Swedish National Board of Health and Welfare publication-title: Lancet (London, England) doi: 10.1016/S0140-6736(85)92204-4 – volume: 244 start-page: 381 year: 2007 end-page: 388 ident: CR9 article-title: Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study publication-title: Radiology doi: 10.1148/radiol.2442060461 – volume: 3 start-page: 243 year: 2003 end-page: 252 ident: CR2 article-title: The case for early detection publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1041 – volume: 29 start-page: 1405 year: 2003 end-page: 1413 ident: CR41 article-title: Localized harmonic motion imaging: theory, simulations and experiments publication-title: Ultrasound Med. Biol. doi: 10.1016/S0301-5629(03)00953-0 – volume: 31 start-page: 895 year: 2012 end-page: 902 ident: CR62 article-title: Effects of Precompression on Elasticity Imaging of the Breast publication-title: J. Ultrasound Med. doi: 10.7863/jum.2012.31.6.895 – volume: 353 start-page: 1773 year: 2005 end-page: 1783 ident: CR7 article-title: Diagnostic performance of digital versus film mammography for breast-cancer screening publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa052911 – volume: 69 start-page: 7 year: 2019 end-page: 34 ident: CR1 article-title: Cancer statistics, 2019 publication-title: CA. Cancer J. Clin. doi: 10.3322/caac.21551 – volume: 221 start-page: 641 year: 2001 end-page: 649 ident: CR16 article-title: Clinical utility of bilateral whole-breast US in the evaluation of women with dense breast tissue publication-title: Radiology doi: 10.1148/radiol.2213010364 – volume: 110 start-page: 625 year: 2001 end-page: 634 ident: CR30 article-title: On the feasibility of remote palpation using acoustic radiation force publication-title: J. Acoust. Soc. Am. doi: 10.1121/1.1378344 – volume: 33 start-page: 1067 year: 1995 end-page: 1080 ident: CR24 article-title: Pathology of benign and malignant breast disorders publication-title: Radiol. Clin. N. Am. – volume: 10 start-page: 4614 year: 2020 end-page: 4626 ident: CR59 article-title: Noninvasive Young’s modulus visualization of fibrosis progression and delineation of pancreatic ductal adenocarcinoma (PDAC) tumors using Harmonic Motion Elastography (HME) in vivo publication-title: Theranostics doi: 10.7150/thno.37965 – volume: 51 start-page: 396 year: 2004 end-page: 409 ident: CR33 article-title: Supersonic shear imaging: a new technique for soft tissue elasticity mapping publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2004.1295425 – volume: 356 start-page: 227 year: 2007 end-page: 236 ident: CR6 article-title: Mammographic Density and the Risk and Detection of Breast Cancer publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa062790 – volume: 13 start-page: 111 year: 1991 end-page: 134 ident: CR26 article-title: Elastography: A quantitative method for imaging the elasticity of biological tissues publication-title: Ultrason. Imaging doi: 10.1177/016173469101300201 – ident: CR64 – volume: 31 start-page: 1821 year: 2012 end-page: 1832 ident: CR34 article-title: Comb-push ultrasound shear elastography (CUSE): A novel method for two-dimensional shear elasticity imaging of soft tissues publication-title: IEEE Trans. Med. Imaging doi: 10.1109/TMI.2012.2205586 – volume: 32 start-page: 61 year: 2006 end-page: 72 ident: CR66 article-title: Analysis of contrast in images generated with transient acoustic radiation force publication-title: Ultrasound Med. Biol. doi: 10.1016/j.ultrasmedbio.2005.08.008 – volume: 126 start-page: 143 year: 2017 end-page: 148 ident: CR42 article-title: Parametric array signal in confocal vibro-acoustography publication-title: Appl. Acoust. doi: 10.1016/j.apacoust.2017.05.022 – volume: 123 start-page: 1 year: 2018 end-page: 12 ident: CR21 article-title: Automated breast ultrasound: basic principles and emerging clinical applications publication-title: Radiol. Med. doi: 10.1007/s11547-017-0805-z – volume: 65 start-page: 292 year: 2018 end-page: 294 ident: CR60 article-title: Focused ultrasound steering for harmonic motion imaging publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2017.2781188 – volume: 69 start-page: 349 year: 1982 end-page: 355 ident: CR3 article-title: Ten- to fourteen-year effect of screening on breast cancer mortality publication-title: J. Natl. Cancer Inst. – volume: 204 start-page: 234 year: 2015 end-page: 240 ident: CR17 article-title: Screening Breast ultrasound: past, present, and future publication-title: Am. J. Roentgenol. doi: 10.2214/AJR.13.12072 – volume: 41 start-page: 1126 year: 2015 end-page: 1147 ident: CR53 article-title: WFUMB guidelines and recommendations for clinical use of ultrasound elastography: part 1: basic principles and terminology publication-title: Ultrasound Med. Biol. doi: 10.1016/j.ultrasmedbio.2015.03.009 – volume: 62 start-page: 3111 year: 2017 end-page: 3123 ident: CR50 article-title: Fast lesion mapping during HIFU treatment using harmonic motion imaging guided focused ultrasound (HMIgFUS) in vitro and in vivo publication-title: Phys. Med. Biol. doi: 10.1088/1361-6560/aa6024 – year: 1995 ident: CR23 article-title: Biophysical bases of elasticity imaging publication-title: Springer, Boston. doi: 10.1007/978-1-4615-1943-0_23 – volume: 213 start-page: 889 year: 1999 end-page: 894 ident: CR12 article-title: Benign versus malignant solid breast masses: US differentiation publication-title: Radiology doi: 10.1148/radiology.213.3.r99dc20889 – volume: 10 start-page: e0119398 year: 2015 ident: CR52 article-title: Comb-push ultrasound shear elastography of breast masses: initial results show promise publication-title: PLoS ONE doi: 10.1371/journal.pone.0119398 – volume: 21 start-page: 1153 year: 1995 end-page: 1162 ident: CR54 article-title: Ultrasound tissue displacement imaging with application to breast cancer publication-title: Ultrasound Med. Biol. doi: 10.1016/0301-5629(95)02005-5 – volume: 15 start-page: 408 year: 2018 end-page: 414 ident: CR10 article-title: Breast cancer screening in women at higher-than-average risk: recommendations from the ACR publication-title: J. Am. Coll. Radiol. doi: 10.1016/j.jacr.2017.11.034 – volume: 45 start-page: 5244 year: 2018 end-page: 5250 ident: CR58 article-title: Technical note: In vivo Young’s modulus mapping of pancreatic ductal adenocarcinoma during HIFU ablation using harmonic motion elastography (HME) publication-title: Med. Phys. doi: 10.1002/mp.13170 – volume: 23 start-page: 2432 year: 2013 end-page: 2440 ident: CR35 article-title: Shear-wave elastography in the diagnosis of solid breast masses: What leads to false-negative or false-positive results? publication-title: Eur. Radiol. doi: 10.1007/s00330-013-2854-6 – volume: 96 start-page: 6603 year: 1999 ident: CR38 article-title: Vibro-acoustography: An imaging modality based on ultrasound-stimulated acoustic emission publication-title: PNAS doi: 10.1073/pnas.96.12.6603 – volume: 52 start-page: 1565 year: 2007 end-page: 1576 ident: CR22 article-title: Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/52/6/002 – year: 2018 ident: CR49 publication-title: Development of a Harmonic Motion Imaging guided Focused Ultrasound system for breast tumor characterization and treatment monitoring. doi: 10.7916/D8KS83H7 – volume: 24 start-page: 1419 year: 1998 end-page: 1435 ident: CR29 article-title: Shear wave elasticity imaging: A new ultrasonic technology of medical diagnostics publication-title: Ultrasound Med. Biol. doi: 10.1016/S0301-5629(98)00110-0 – volume: 76 start-page: 626 year: 1995 end-page: 630 ident: CR14 article-title: Malignant breast masses detected only by ultrasound. A retrospective review publication-title: Cancer doi: 10.1002/1097-0142(19950815)76:4<626::AID-CNCR2820760413>3.0.CO;2-Z – volume: 214 start-page: 59 year: 2000 end-page: 66 ident: CR15 article-title: Multicentric and multifocal cancer: whole-breast US in preoperative evaluation publication-title: Radiology doi: 10.1148/radiology.214.1.r00ja2559 – volume: 57 start-page: 75 year: 2007 end-page: 89 ident: CR8 article-title: American cancer society guidelines for breast screening with MRI as an adjunct to mammography publication-title: CA. Cancer J. Clin. doi: 10.3322/canjclin.57.2.75 – volume: 225 start-page: 165 year: 2002 end-page: 175 ident: CR5 article-title: Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations publication-title: Radiology doi: 10.1148/radiol.2251011667 – volume: 108 start-page: djv367 year: 2016 ident: CR19 article-title: Ultrasound as the Primary Screening Test for Breast Cancer: Analysis From ACRIN 6666 publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/djv367 – volume: 29 start-page: 1705 year: 2003 end-page: 1713 ident: CR25 article-title: Transient elastography: a new noninvasive method for assessment of hepatic fibrosis publication-title: Ultrasoun. Med. Biol. doi: 10.1016/j.ultrasmedbio.2003.07.001 – ident: CR55 – volume: 124 start-page: 193 year: 1954 end-page: 212 ident: CR63 article-title: Movements of the thoracic cage and diaphragm in respiration publication-title: J. Physiol. doi: 10.1113/jphysiol.1954.sp005099 – volume: 29 start-page: 1715 year: 2003 end-page: 1723 ident: CR32 article-title: Shear-wave generation using acoustic radiation force: in vivo and ex vivo results publication-title: Ultrasound Med. Biol. doi: 10.1016/j.ultrasmedbio.2003.08.008 – volume: 60 start-page: 685 year: 2013 end-page: 701 ident: CR27 article-title: Acoustic radiation force elasticity imaging in diagnostic ultrasound publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2013.2617 – volume: 126 start-page: 143 year: 2017 ident: 71960_CR42 publication-title: Appl. Acoust. doi: 10.1016/j.apacoust.2017.05.022 – volume: 59 start-page: 1421 year: 2012 ident: 71960_CR40 publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2012.2343 – volume: 71 start-page: 92 year: 2016 ident: 71960_CR56 publication-title: Clin. Radiol. doi: 10.1016/j.crad.2015.10.029 – volume: 356 start-page: 227 year: 2007 ident: 71960_CR6 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa062790 – volume: 13 start-page: 111 year: 1991 ident: 71960_CR26 publication-title: Ultrason. Imaging doi: 10.1177/016173469101300201 – ident: 71960_CR55 doi: 10.1186/bcr764 – volume: 108 start-page: djv367 year: 2016 ident: 71960_CR19 publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/djv367 – volume: 213 start-page: 889 year: 1999 ident: 71960_CR12 publication-title: Radiology doi: 10.1148/radiology.213.3.r99dc20889 – volume: 28 start-page: 144 year: 2006 ident: 71960_CR43 publication-title: Ultrason. Imaging doi: 10.1177/016173460602800302 – volume: 225 start-page: 165 year: 2002 ident: 71960_CR5 publication-title: Radiology doi: 10.1148/radiol.2251011667 – volume: 62 start-page: 1662 year: 2015 ident: 71960_CR46 publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2015.007113 – volume: 41 start-page: 1126 year: 2015 ident: 71960_CR53 publication-title: Ultrasound Med. Biol. doi: 10.1016/j.ultrasmedbio.2015.03.009 – volume: 32 start-page: 61 year: 2006 ident: 71960_CR66 publication-title: Ultrasound Med. Biol. doi: 10.1016/j.ultrasmedbio.2005.08.008 – volume: 76 start-page: 626 year: 1995 ident: 71960_CR14 publication-title: Cancer doi: 10.1002/1097-0142(19950815)76:4<626::AID-CNCR2820760413>3.0.CO;2-Z – volume: 57 start-page: 75 year: 2007 ident: 71960_CR8 publication-title: CA. Cancer J. Clin. doi: 10.3322/canjclin.57.2.75 – volume: 31 start-page: 895 year: 2012 ident: 71960_CR62 publication-title: J. Ultrasound Med. doi: 10.7863/jum.2012.31.6.895 – volume: 280 start-page: 82 year: 1998 ident: 71960_CR37 publication-title: Science doi: 10.1126/science.280.5360.82 – volume: 20 start-page: 3 year: 2013 ident: 71960_CR51 publication-title: Breast Cancer doi: 10.1007/s12282-011-0326-x – volume: 69 start-page: 349 year: 1982 ident: 71960_CR3 publication-title: J. Natl. Cancer Inst. – volume: 60 start-page: 685 year: 2013 ident: 71960_CR27 publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2013.2617 – volume: 214 start-page: 59 year: 2000 ident: 71960_CR15 publication-title: Radiology doi: 10.1148/radiology.214.1.r00ja2559 – volume: 33 start-page: 1067 year: 1995 ident: 71960_CR24 publication-title: Radiol. Clin. N. Am. doi: 10.1016/S0033-8389(22)00643-1 – volume: 110 start-page: 625 year: 2001 ident: 71960_CR30 publication-title: J. Acoust. Soc. Am. doi: 10.1121/1.1378344 – volume: 62 start-page: 3111 year: 2017 ident: 71960_CR50 publication-title: Phys. Med. Biol. doi: 10.1088/1361-6560/aa6024 – volume: 51 start-page: 396 year: 2004 ident: 71960_CR33 publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2004.1295425 – volume: 10 start-page: 4614 year: 2020 ident: 71960_CR59 publication-title: Theranostics doi: 10.7150/thno.37965 – volume: 60 start-page: 2853 year: 2015 ident: 71960_CR47 publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/60/7/2853 – volume: 24 start-page: 1419 year: 1998 ident: 71960_CR29 publication-title: Ultrasound Med. Biol. doi: 10.1016/S0301-5629(98)00110-0 – volume: 45 start-page: 5244 year: 2018 ident: 71960_CR58 publication-title: Med. Phys. doi: 10.1002/mp.13170 – volume: 239 start-page: 341 year: 2006 ident: 71960_CR28 publication-title: Radiology doi: 10.1148/radiol.2391041676 – volume: 84 start-page: 224 year: 2019 ident: 71960_CR36 publication-title: Polish J. Radiol. doi: 10.5114/pjr.2019.86852 – volume: 244 start-page: 381 year: 2007 ident: 71960_CR9 publication-title: Radiology doi: 10.1148/radiol.2442060461 – volume: 49 start-page: 4395 year: 2004 ident: 71960_CR57 publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/49/18/014 – volume: 353 start-page: 1773 year: 2005 ident: 71960_CR7 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa052911 – volume: 68 start-page: 463 year: 2013 ident: 71960_CR39 publication-title: Clinics doi: 10.6061/clinics/2013(04)05 – volume: 52 start-page: 539 year: 2014 ident: 71960_CR20 publication-title: Radiol. Clin. N. Am. doi: 10.1016/j.rcl.2014.01.002 – ident: 71960_CR64 doi: 10.1109/ULTSYM.2018.8579993 – volume: 1 start-page: 829 year: 1985 ident: 71960_CR4 publication-title: Lancet (London, England) doi: 10.1016/S0140-6736(85)92204-4 – volume: 123 start-page: 1 year: 2018 ident: 71960_CR21 publication-title: Radiol. Med. doi: 10.1007/s11547-017-0805-z – volume: 10 start-page: e0119398 year: 2015 ident: 71960_CR52 publication-title: PLoS ONE doi: 10.1371/journal.pone.0119398 – volume-title: Breast ultrasound year: 2004 ident: 71960_CR61 – year: 2018 ident: 71960_CR49 publication-title: Development of a Harmonic Motion Imaging guided Focused Ultrasound system for breast tumor characterization and treatment monitoring. doi: 10.7916/D8KS83H7 – volume: 1 start-page: 728 year: 2004 ident: 71960_CR31 publication-title: IEEE Ultrason. Symp. – volume: 204 start-page: 234 year: 2015 ident: 71960_CR17 publication-title: Am. J. Roentgenol. doi: 10.2214/AJR.13.12072 – volume: 221 start-page: 641 year: 2001 ident: 71960_CR16 publication-title: Radiology doi: 10.1148/radiol.2213010364 – volume: 23 start-page: 2432 year: 2013 ident: 71960_CR35 publication-title: Eur. Radiol. doi: 10.1007/s00330-013-2854-6 – volume: 29 start-page: 1715 year: 2003 ident: 71960_CR32 publication-title: Ultrasound Med. Biol. doi: 10.1016/j.ultrasmedbio.2003.08.008 – volume: 18 start-page: 46 year: 2016 ident: 71960_CR48 publication-title: Breast Cancer Res. doi: 10.1186/s13058-016-0707-3 – volume: 15 start-page: 408 year: 2018 ident: 71960_CR10 publication-title: J. Am. Coll. Radiol. doi: 10.1016/j.jacr.2017.11.034 – volume: 196 start-page: 123 year: 1995 ident: 71960_CR11 publication-title: Radiology doi: 10.1148/radiology.196.1.7784555 – volume: 207 start-page: 191 year: 1998 ident: 71960_CR13 publication-title: Radiology doi: 10.1148/radiology.207.1.9530316 – volume: 29 start-page: 1405 year: 2003 ident: 71960_CR41 publication-title: Ultrasound Med. Biol. doi: 10.1016/S0301-5629(03)00953-0 – volume: 29 start-page: 1705 year: 2003 ident: 71960_CR25 publication-title: Ultrasoun. Med. Biol. doi: 10.1016/j.ultrasmedbio.2003.07.001 – volume: 31 start-page: 1821 year: 2012 ident: 71960_CR34 publication-title: IEEE Trans. Med. Imaging doi: 10.1109/TMI.2012.2205586 – volume: 26 start-page: 1297 year: 2020 ident: 71960_CR44 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-18-3669 – volume: 57 start-page: 1347 year: 2010 ident: 71960_CR65 publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2010.1554 – volume: 69 start-page: 7 year: 2019 ident: 71960_CR1 publication-title: CA. Cancer J. Clin. doi: 10.3322/caac.21551 – volume: 21 start-page: 1153 year: 1995 ident: 71960_CR54 publication-title: Ultrasound Med. Biol. doi: 10.1016/0301-5629(95)02005-5 – volume: 52 start-page: 1565 year: 2007 ident: 71960_CR22 publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/52/6/002 – volume: 124 start-page: 193 year: 1954 ident: 71960_CR63 publication-title: J. Physiol. doi: 10.1113/jphysiol.1954.sp005099 – volume: 65 start-page: 292 year: 2018 ident: 71960_CR60 publication-title: IEEE Trans. Ultrason. Ferroelectr. Freq. Control doi: 10.1109/TUFFC.2017.2781188 – ident: 71960_CR45 doi: 10.1109/ULTSYM.2017.8091551 – volume: 96 start-page: 6603 year: 1999 ident: 71960_CR38 publication-title: PNAS doi: 10.1073/pnas.96.12.6603 – volume: 3 start-page: 243 year: 2003 ident: 71960_CR2 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1041 – volume: 299 start-page: 2151 year: 2008 ident: 71960_CR18 publication-title: JAMA J. Am. Med. Assoc. doi: 10.1001/jama.299.18.2151 – year: 1995 ident: 71960_CR23 publication-title: Springer, Boston. doi: 10.1007/978-1-4615-1943-0_23
SSID	ssj0000529419
Score	2.391963
Snippet	Non-invasive diagnosis of breast cancer is still challenging due to the low specificity of the imaging modalities that calls for unnecessary biopsies. The...
SourceID	pubmedcentral proquest pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	15254
SubjectTerms	631/1647/245/1859 631/67/1347 639/166/985 692/308/575 692/699/67/1347 Biopsy Breast - diagnostic imaging Breast cancer Breast Neoplasms - diagnostic imaging Elastic properties Elasticity Imaging Techniques - methods Feasibility Studies Female High-Intensity Focused Ultrasound Ablation - methods Histology Humanities and Social Sciences Humans Mechanical properties Middle Aged Motion multidisciplinary Nonlinear systems Science Science (multidisciplinary) Tissues Transducers Tumors
Title	Harmonic motion imaging of human breast masses: an in vivo clinical feasibility
URI	https://link.springer.com/article/10.1038/s41598-020-71960-5 https://www.ncbi.nlm.nih.gov/pubmed/32943648 https://www.proquest.com/docview/2695800975 https://www.proquest.com/docview/2444381346 https://pubmed.ncbi.nlm.nih.gov/PMC7498461
Volume	10
WOSCitedRecordID	wos000573742900028&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M7P dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: 7X7 dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: PIMPY dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M2P dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9QwEB3RFiQufEMDZWUkbhA1ie3Y5oIAtSqHLhECaTlFjpOokdik3d2u1H_PjJNstVT0wiE-xI4SZ8b22DPzHsBboW3ieG3C2Lg0JPiWsLBpRTCuaJyUdaVN6ckm1HSqZzOTDQduyyGscpwT_URddo7OyA-T1EhNWQfy4_lFSKxR5F0dKDR2YI9QErgP3cs2ZyzkxRKxGXJlIq4Pl7heUU4Z7pkU6l4Uyu316IaReTNW8i-HqV-Hjh_-bw8ewYPBAmWfepV5DHeq9gnc6zkpr57CtxO7mBNeLusJflgz90RGrKuZJ_RjBcWxr9jckr_4A8M7TcvWzbpjY5olq7FFH3Z79Qx-Hh_9-HISDqwLoRNKrEJBcD6FVZWp0RwTOimj1IlYSBfbuJKpLZOkcFbGvKrR-HHOWIlmTm24jqQuav4cdtuurfaB4e6MlyWl8uKmTzutBV4mKaSKYqcLFUA8_vvcDZDkxIzxO_euca7zXl45yiv38splAO82z5z3gBy3tj4YZZEPg3OZXwsigDebahxW5CuxbdVdYhshCPyMizSAF70GbF7HUat4KnQAaks3Ng0Isnu7pm3OPHS3EgYNvjiA96MWXX_Wv3vx8vZevIL7CWk0EVuoA9hdLS6r13DXrVfNcjGBHTVTvtQT2Pt8NM2-T_zJA5anSTbxQwZrsq-n2a8_Hi8YkA
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAoIL70eggJHgBFETPxIbCSEEVFu1LD0UqbfgOImIxCZld7to_xS_kRkn2Wqp6K0HDrlsvJt4_dkz9sx8H8ALqS13ojJhbFwSEn1LmNukJBpXdE6KqtSm8GIT6Xisj47MwQb8HmphKK1yWBP9Ql20js7It3lilKaqA_Xu-GdIqlEUXR0kNDpY7JXLX7hlm73d_Yjj-5LznU-HH0ZhryoQOpnKeSiJria3aWkqdDek5kWUOBlL5WIblyqxBee5syoWZYXG3TljFZrxyggdKZ1XAn_3ElxGN4Jrnyp4sDrToaiZjE1fmxMJvT1D-0g1bLhHSxHrUajW7d8Zp_ZsbuZfAVpv93Zu_m__2C240XvY7H03JW7DRtncgaud5ubyLnwZ2emE-IBZJ2DE6okXamJtxbxgIcspT3_OJpbi4W8YflI3bFEvWjaUkbIKW3Rpxct78PVCenMfNpu2KR8Cw92nKAoqVcZNrXZaS7wMz1UaxU7naQDxMNaZ6ynXSfnjR-ZD_0JnHT4yxEfm8ZGpAF6tvnPcEY6c23prGPusX3xm2enAB_B8dRuXDYoF2aZsT7CNlETuJmQSwIMOcavHCUSxSKQOIF3D4qoBUZKv32nq756aPJUGHdo4gNcDak9f69-9eHR-L57BtdHh5_1sf3e89xiuc5pNJOKRbsHmfHpSPoErbjGvZ9Onfjoy-HbRaP4DPuttHw
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6V8hAX3pRAASPBCaJNYiexkRBClFWromUPIPUWHMcRkbpJ2d0u2r_Gr2PGeVRLRW89cMglcR5OPnvGmZnvA3gppI4ML5UfKpP4RN_i5zqxROOKzklRWqkKJzaRTiby6EhNt-B3XwtDaZX9nOgm6qIx9I98FCUqllR1EI_KLi1iujd-f_LTJwUpirT2chotRA7t-hcu3xbvDvbwW7-KovGnrx_3_U5hwDciFUtfEHVNrlOrSnQ9hIyKIDEiFLEJdWjjRBdRlBsdh9yWaOiNUTpGk14qLoNY5iXH616BqymRlru0wenwf4ciaCJUXZ1OwOVogbaS6tlwvZYi7gM_3rSF5xzc83mafwVrnQ0c3_6f394duNV53uxDO1Tuwpat78H1VotzfR--7Ov5jHiCWStsxKqZE3BiTcmckCHLKX9_yWaa4uRvGe6paraqVg3ry0tZiS3adOP1A_h2Kb15CNt1U9tHwHBVyouCSphxsSuNlAI3FeVxGoRG5qkHYf_dM9NRsZMiyHHmUgK4zFqsZIiVzGEliz14PZxz0hKRXNh6t8dB1k1Ki-wMBB68GA7jdEIxIl3b5hTbCEGkb1wkHuy06BtuxxHRPBHSg3QDl0MDoirfPFJXPxxleSoUOrqhB296BJ891r978fjiXjyHGwji7PPB5PAJ3IxoYJG2R7oL28v5qX0K18xqWS3mz9zIZPD9ssH8B10Wddw
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Harmonic+motion+imaging+of+human+breast+masses%3A+an+in+vivo+clinical+feasibility&rft.jtitle=Scientific+reports&rft.au=Saharkhiz%2C+Niloufar&rft.au=Ha%2C+Richard&rft.au=Taback%2C+Bret&rft.au=Li%2C+Xiaoyue+Judy&rft.date=2020-09-17&rft.issn=2045-2322&rft.eissn=2045-2322&rft.volume=10&rft.issue=1&rft.spage=15254&rft_id=info:doi/10.1038%2Fs41598-020-71960-5&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon