Treatment of malignant superior vena cava syndrome by endovascular stent insertion: Experience on 52 patients with lung cancer

Background: Superior vena cava syndrome (SVCS) is a frequent presentation of malignancies involving the mediastinum and can seriously compromise treatment options and prognosis. Stenting of superior vena cava is a well-known but not so commonly used technique to alleviate this syndrome. Patients and...

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Vydáno v:	Lung cancer (Amsterdam, Netherlands) Ročník 43; číslo 2; s. 209 - 214
Hlavní autoři:	Urruticoechea, A., Mesı́a, R., Domı́nguez, J., Falo, C., Escalante, E., Montes, A., Sancho, C., Cardenal, F., Majem, M., Germà, J.R.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Shannon Elsevier Ireland Ltd 01.02.2004 Elsevier Science
Témata:	Adult Aged Anticoagulants - adverse effects Anticoagulants - therapeutic use Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Hemorrhage - etiology Humans Lung cancer Lung Neoplasms - complications Male Mediastinum malignances Medical sciences Middle Aged Non-small cell lung cancer Prognosis Small cell lung cancer Stent Stents Superior vena cava syndrome Superior Vena Cava Syndrome - etiology Superior Vena Cava Syndrome - pathology Superior Vena Cava Syndrome - surgery Treatment Outcome Vascular Surgical Procedures - instrumentation Vascular Surgical Procedures - methods Vena cava obstruction Small cell lung cancer Lung cancer Non-small cell lung cancer Superior vena cava syndrome Mediastinum malignances Stent Vena cava obstruction Human Lung disease Endoprosthesis Respiratory disease Insertion Instrumentation therapy Cardiovascular disease Malignant tumor Bronchopulmonary malignant tumor Vascular disease Vena cava disease Bronchus disease Superior vena cava
ISSN:	0169-5002, 1872-8332
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Shrnutí:	Background: Superior vena cava syndrome (SVCS) is a frequent presentation of malignancies involving the mediastinum and can seriously compromise treatment options and prognosis. Stenting of superior vena cava is a well-known but not so commonly used technique to alleviate this syndrome. Patients and methods: Between August 1993 and December 2000 we performed 52 stenting procedures in patients affected by non-small cell lung cancer (NSCLC). Results: Phlebographic resolution of the obstruction was achieved in 100% of cases with symptomatic and subjective improvement in more than 80%. One major complication was observed due to bleeding during anticoagulation. Re-obstruction of the stent occurred in only 17% of the cases, the majority due to disease progression. Improvement of the syndrome allowed hydration necessary for full dose platinum treatment when indicated in patients affected by lung cancer. Conclusions: Stenting of the superior vena cava syndrome is a safe and effective procedure achieving a rapid alleviation of symptoms in almost all patients, and allowing for full dose treatment in lung cancer patients. This procedure could change the traditional poorer prognosis attributed to non-small cell lung cancer patients presenting with this syndrome.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0169-5002 1872-8332
DOI:	10.1016/S0169-5002(03)00361-1