Programming multicellular assembly with synthetic cell adhesion molecules

Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell–cell interactions in processes as diverse as tissue development, immune cell trafficking and the wiring of the nervous system 1 – 4 . Here we show that a wide array of synthetic cell adhesion molecules can be...

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Vydáno v:	Nature (London) Ročník 614; číslo 7946; s. 144 - 152
Hlavní autoři:	Stevens, Adam J., Harris, Andrew R., Gerdts, Josiah, Kim, Ki H., Trentesaux, Coralie, Ramirez, Jonathan T., McKeithan, Wesley L., Fattahi, Faranak, Klein, Ophir D., Fletcher, Daniel A., Lim, Wendell A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 02.02.2023 Nature Publishing Group
Témata:	13/106 13/107 14 14/19 631/553/1886 631/553/552 631/61/2035 631/80/79/1236 631/80/79/1902 96/95 Adhesion Assembly Binding Sites Cadherins - chemistry Cell Adhesion Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism Cell Communication Cell Engineering Cell interactions Contact angle Cytology Domains Genotype & phenotype Humanities and Social Sciences Immune system Integrins Integrins - chemistry Interfaces Intracellular Modularity Morphology multidisciplinary Neurosciences Protein Domains Science Science (multidisciplinary) Synthetic Biology - methods Tissue engineering Wiring
ISSN:	0028-0836, 1476-4687, 1476-4687
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Popis
Shrnutí:	Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell–cell interactions in processes as diverse as tissue development, immune cell trafficking and the wiring of the nervous system 1 – 4 . Here we show that a wide array of synthetic cell adhesion molecules can be generated by combining orthogonal extracellular interactions with intracellular domains from native adhesion molecules, such as cadherins and integrins. The resulting molecules yield customized cell–cell interactions with adhesion properties that are similar to native interactions. The identity of the intracellular domain of the synthetic cell adhesion molecules specifies interface morphology and mechanics, whereas diverse homotypic or heterotypic extracellular interaction domains independently specify the connectivity between cells. This toolkit of orthogonal adhesion molecules enables the rationally programmed assembly of multicellular architectures, as well as systematic remodelling of native tissues. The modularity of synthetic cell adhesion molecules provides fundamental insights into how distinct classes of cell–cell interfaces may have evolved. Overall, these tools offer powerful abilities for cell and tissue engineering and for systematically studying multicellular organization. Synthetic cell adhesion molecules yield customized cell–cell interactions with adhesion properties that are similar to native interactions, and offer abilities for cell and tissue engineering and for systematically studying multicellular organization.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0028-0836 1476-4687 1476-4687
DOI:	10.1038/s41586-022-05622-z