NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling

Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdo...

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Bibliographic Details
Published in:	Nature cell biology Vol. 24; no. 9; pp. 1422 - 1432
Main Authors:	Verma, Sachin, Crawford, David, Khateb, Ali, Feng, Yongmei, Sergienko, Eduard, Pathria, Gaurav, Ma, Chen-Ting, Olson, Steven H., Scott, David, Murad, Rabi, Ruppin, Eytan, Jackson, Michael, Ronai, Ze’ev A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.09.2022 Nature Publishing Group
Subjects:	13 13/1 13/106 13/109 13/2 13/31 13/44 13/89 13/95 14 38 38/39 45 45/41 631/67/1813/1634 631/80/82/23 631/80/86/2366 64 64/60 692/699/67/2327 82 96 Activating transcription factor 3 Addictions Amino Acid Metabolism, Inborn Errors - genetics Amino Acid Metabolism, Inborn Errors - metabolism Apoptosis Biomedical and Life Sciences Brain Diseases, Metabolic - genetics Brain Diseases, Metabolic - metabolism Brain Diseases, Metabolic - pathology Cancer Research Catabolism Cell Biology Cell death Depletion Developmental Biology DNA Glutaryl-CoA dehydrogenase Glutaryl-CoA Dehydrogenase - genetics Glutaryl-CoA Dehydrogenase - metabolism Humans Inactivation Ketoglutarate Dehydrogenase Complex Life Sciences Lysine Melanoma Melanoma - genetics Mitochondria Mitochondrial Proteins Mortality NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Protein turnover Proteins Signal transduction Signaling Stem Cells Tumors
ISSN:	1465-7392, 1476-4679, 1476-4679
Online Access:	Get full text
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