NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling
Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdo...
Uloženo v:
| Vydáno v: | Nature cell biology Ročník 24; číslo 9; s. 1422 - 1432 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
01.09.2022
Nature Publishing Group |
| Témata: | |
| ISSN: | 1465-7392, 1476-4679, 1476-4679 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdown induced cell death programmes in melanoma cells, an activity blocked by inhibition of the upstream lysine catabolism enzyme DHTKD1. The transcription factor NRF2 mediates GCDH-dependent melanoma cell death programmes. Mechanistically, GCDH knockdown induces NRF2 glutarylation, increasing its stability and DNA binding activity, with a concomitant transcriptional upregulation of ATF4, ATF3, DDIT3 and CHAC1, resulting in cell death. In vivo, inducible inactivation of GCDH effectively inhibited melanoma tumour growth. Correspondingly, reduced GCDH expression correlated with improved survival of patients with melanoma. These findings identify melanoma cell addiction to GCDH, limiting apoptotic signalling by controlling NRF2 glutarylation. Inhibiting the GCDH pathway could thus represent a therapeutic approach to treat melanoma.
Verma et al. demonstrate that GCDH depletion in melanoma cells induces NRF2 glutarylation, upregulates ATF4 and ATF3 signalling and promotes cell death, thereby suppressing tumour growth. |
|---|---|
| AbstractList | Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdown induced cell death programmes in melanoma cells, an activity blocked by inhibition of the upstream lysine catabolism enzyme DHTKD1. The transcription factor NRF2 mediates GCDH-dependent melanoma cell death programmes. Mechanistically, GCDH knockdown induces NRF2 glutarylation, increasing its stability and DNA binding activity, with a concomitant transcriptional upregulation of ATF4, ATF3, DDIT3 and CHAC1, resulting in cell death. In vivo, inducible inactivation of GCDH effectively inhibited melanoma tumour growth. Correspondingly, reduced GCDH expression correlated with improved survival of patients with melanoma. These findings identify melanoma cell addiction to GCDH, limiting apoptotic signalling by controlling NRF2 glutarylation. Inhibiting the GCDH pathway could thus represent a therapeutic approach to treat melanoma.Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdown induced cell death programmes in melanoma cells, an activity blocked by inhibition of the upstream lysine catabolism enzyme DHTKD1. The transcription factor NRF2 mediates GCDH-dependent melanoma cell death programmes. Mechanistically, GCDH knockdown induces NRF2 glutarylation, increasing its stability and DNA binding activity, with a concomitant transcriptional upregulation of ATF4, ATF3, DDIT3 and CHAC1, resulting in cell death. In vivo, inducible inactivation of GCDH effectively inhibited melanoma tumour growth. Correspondingly, reduced GCDH expression correlated with improved survival of patients with melanoma. These findings identify melanoma cell addiction to GCDH, limiting apoptotic signalling by controlling NRF2 glutarylation. Inhibiting the GCDH pathway could thus represent a therapeutic approach to treat melanoma. Tumor dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein Glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdown induced cell death programs in melanoma cells, an activity blocked by inhibition of the upstream lysine catabolism enzyme DHTKD1. The transcription factor NRF2 mediates GCDH-dependent melanoma cell death programs. Mechanistically, GCDH KD induces NRF2 glutarylation, increasing its stability and DNA binding activity, with a concomitant transcriptional upregulation of ATF4, ATF3, DDIT3, and CHAC1, resulting in cell death. In vivo, inducible inactivation of GCDH effectively inhibited melanoma ftumor growth. Correspondingly, reduced GCDH expression correlated with improved survival of melanoma patients. These findings identify melanoma cell addiction to GCDH, limiting apoptotic signaling by controlling NRF2 glutarylation. Inhibiting the GCDH pathway could thus represent a therapeutic approach to treat melanoma. Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdown induced cell death programmes in melanoma cells, an activity blocked by inhibition of the upstream lysine catabolism enzyme DHTKD1. The transcription factor NRF2 mediates GCDH-dependent melanoma cell death programmes. Mechanistically, GCDH knockdown induces NRF2 glutarylation, increasing its stability and DNA binding activity, with a concomitant transcriptional upregulation of ATF4, ATF3, DDIT3 and CHAC1, resulting in cell death. In vivo, inducible inactivation of GCDH effectively inhibited melanoma tumour growth. Correspondingly, reduced GCDH expression correlated with improved survival of patients with melanoma. These findings identify melanoma cell addiction to GCDH, limiting apoptotic signalling by controlling NRF2 glutarylation. Inhibiting the GCDH pathway could thus represent a therapeutic approach to treat melanoma. Verma et al. demonstrate that GCDH depletion in melanoma cells induces NRF2 glutarylation, upregulates ATF4 and ATF3 signalling and promotes cell death, thereby suppressing tumour growth. Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdown induced cell death programmes in melanoma cells, an activity blocked by inhibition of the upstream lysine catabolism enzyme DHTKD1. The transcription factor NRF2 mediates GCDH-dependent melanoma cell death programmes. Mechanistically, GCDH knockdown induces NRF2 glutarylation, increasing its stability and DNA binding activity, with a concomitant transcriptional upregulation of ATF4, ATF3, DDIT3 and CHAC1, resulting in cell death. In vivo, inducible inactivation of GCDH effectively inhibited melanoma tumour growth. Correspondingly, reduced GCDH expression correlated with improved survival of patients with melanoma. These findings identify melanoma cell addiction to GCDH, limiting apoptotic signalling by controlling NRF2 glutarylation. Inhibiting the GCDH pathway could thus represent a therapeutic approach to treat melanoma.Verma et al. demonstrate that GCDH depletion in melanoma cells induces NRF2 glutarylation, upregulates ATF4 and ATF3 signalling and promotes cell death, thereby suppressing tumour growth. Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdown induced cell death programmes in melanoma cells, an activity blocked by inhibition of the upstream lysine catabolism enzyme DHTKD1. The transcription factor NRF2 mediates GCDH-dependent melanoma cell death programmes. Mechanistically, GCDH knockdown induces NRF2 glutarylation, increasing its stability and DNA binding activity, with a concomitant transcriptional upregulation of ATF4, ATF3, DDIT3 and CHAC1, resulting in cell death. In vivo, inducible inactivation of GCDH effectively inhibited melanoma tumour growth. Correspondingly, reduced GCDH expression correlated with improved survival of patients with melanoma. These findings identify melanoma cell addiction to GCDH, limiting apoptotic signalling by controlling NRF2 glutarylation. Inhibiting the GCDH pathway could thus represent a therapeutic approach to treat melanoma. |
| Author | Ma, Chen-Ting Olson, Steven H. Feng, Yongmei Scott, David Murad, Rabi Khateb, Ali Crawford, David Verma, Sachin Ruppin, Eytan Ronai, Ze’ev A. Jackson, Michael Sergienko, Eduard Pathria, Gaurav |
| AuthorAffiliation | 2 Cancer Data Science Lab (CDSL), National Cancer Institute, National Institute of Health, Bethesda, MD 20892 3 Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037 1 Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037 |
| AuthorAffiliation_xml | – name: 3 Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037 – name: 1 Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037 – name: 2 Cancer Data Science Lab (CDSL), National Cancer Institute, National Institute of Health, Bethesda, MD 20892 |
| Author_xml | – sequence: 1 givenname: Sachin surname: Verma fullname: Verma, Sachin organization: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute – sequence: 2 givenname: David surname: Crawford fullname: Crawford, David organization: Cancer Data Science Lab (CDSL), National Cancer Institute, National Institute of Health – sequence: 3 givenname: Ali surname: Khateb fullname: Khateb, Ali organization: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute – sequence: 4 givenname: Yongmei surname: Feng fullname: Feng, Yongmei organization: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute – sequence: 5 givenname: Eduard surname: Sergienko fullname: Sergienko, Eduard organization: Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute – sequence: 6 givenname: Gaurav surname: Pathria fullname: Pathria, Gaurav organization: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, Genentech – sequence: 7 givenname: Chen-Ting surname: Ma fullname: Ma, Chen-Ting organization: Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute – sequence: 8 givenname: Steven H. surname: Olson fullname: Olson, Steven H. organization: Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute – sequence: 9 givenname: David surname: Scott fullname: Scott, David organization: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute – sequence: 10 givenname: Rabi surname: Murad fullname: Murad, Rabi organization: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute – sequence: 11 givenname: Eytan surname: Ruppin fullname: Ruppin, Eytan organization: Cancer Data Science Lab (CDSL), National Cancer Institute, National Institute of Health – sequence: 12 givenname: Michael surname: Jackson fullname: Jackson, Michael organization: Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute – sequence: 13 givenname: Ze’ev A. orcidid: 0000-0002-3859-0400 surname: Ronai fullname: Ronai, Ze’ev A. email: zeev@ronailab.net organization: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36050469$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UU1v1DAUtFAr-gF_gAOKxIVL4NnxR3xBQgttEVUrIThbtmMvrhJ7iZ2q_fd42RZoDz356XlmNG_mCO3FFB1CrzC8w9D17zPFjPEWCGkBZM_am2foEFPBW8qF3NvOnLWik-QAHeV8BYApBfEcHXQcGFAuD9HXi28npJncEHRxuQ6jjmnSjR6GYEtIsSmpOV19OmvMbTOlYRl1CXHd6E3alFSCbXJYRz2OdfkC7Xs9Zvfy7j1GP04-f1-dteeXp19WH89bSwUtbee58Nxgb4gQHqyRdPCcWIu95EY7ywZpDBDjjWG9lbjzrG65Bmx6KW13jD7sdDeLqc6ti2XWo9rMYdLzrUo6qIc_MfxU63StpBSCdaQKvL0TmNOvxeWippCtG-vtLi1ZEQFSUAwSKvTNI-hVWuZ68BaFGYCoIVfU6_8d_bVyn3MF9DuAnVPOs_PKhqK3-VaDYVQY1LZStatU1UrVn0rVTaWSR9R79SdJ3Y6UKziu3fzP9hOs3wbKtXE |
| CitedBy_id | crossref_primary_10_1002_mco2_261 crossref_primary_10_1016_j_phrs_2025_107666 crossref_primary_10_1038_s42255_023_00855_2 crossref_primary_10_1158_2767_9764_CRC_24_0416 crossref_primary_10_1016_j_ijbiomac_2024_133932 crossref_primary_10_1038_s42255_023_00878_9 crossref_primary_10_1016_j_trecan_2025_04_007 crossref_primary_10_1039_D4TB01504E crossref_primary_10_1038_s41392_023_01399_3 crossref_primary_10_31083_j_fbl2909331 crossref_primary_10_3389_fcell_2024_1458716 crossref_primary_10_1007_s44178_024_00138_0 crossref_primary_10_1016_j_tem_2025_08_002 crossref_primary_10_1016_j_ymben_2024_10_009 crossref_primary_10_1016_j_jhep_2024_05_034 crossref_primary_10_1111_exd_70114 crossref_primary_10_1007_s00018_023_05104_z crossref_primary_10_3390_antiox13010070 crossref_primary_10_3390_biomedicines11061512 crossref_primary_10_1007_s00403_025_03958_w crossref_primary_10_1186_s12935_023_03129_9 crossref_primary_10_3390_ijms241814215 crossref_primary_10_34133_research_0862 crossref_primary_10_1080_15548627_2024_2384348 crossref_primary_10_3390_cancers16122262 |
| Cites_doi | 10.1158/2159-8290.CD-12-0095 10.1038/nature22056 10.1111/jnc.14270 10.1016/j.molmed.2016.05.002 10.1038/nature22379 10.1093/bioinformatics/bts635 10.1038/nri.2016.70 10.1016/j.drudis.2016.12.003 10.1016/j.stem.2015.05.016 10.1073/pnas.1014156108 10.1182/blood-2011-01-333427 10.1161/ATVBAHA.110.204354 10.1016/j.cell.2019.07.031 10.1038/ni1003 10.1093/nar/gkq212 10.1038/s41580-019-0123-5 10.1016/j.cell.2018.03.022 10.1016/j.cmet.2020.12.009 10.1016/j.immuni.2014.04.007 10.1016/j.tem.2021.03.003 10.1016/j.ijdevneu.2019.05.005 10.1016/j.jhep.2020.01.023 10.1016/j.ymgme.2020.07.010 10.1093/brain/awl009 10.1038/s41556-019-0415-1 10.1016/j.cell.2016.12.039 10.1016/j.celrep.2018.08.014 10.1016/j.bcp.2018.05.003 10.1093/bioinformatics/btw313 10.1093/bioinformatics/btw354 10.18632/oncotarget.3132 10.1016/j.cmet.2014.03.014 10.4049/jimmunol.182.1.466 10.1038/ng1248 10.1038/nrc.2016.71 10.1038/nm.2557 10.1093/nar/gkp865 10.1126/scitranslmed.aaz5683 10.3390/nu10111564 10.1038/s43018-020-0071-1 10.1038/nature25465 10.1074/mcp.R114.046664 10.1038/s12276-020-0375-3 10.1016/j.ccell.2018.03.022 10.1016/j.bbadis.2017.05.018 10.1074/jbc.M101198200 10.1038/nm.4407 10.1016/j.cell.2015.08.016 10.1016/j.cell.2017.03.023 10.1128/MCB.01639-08 10.1007/s12035-015-9548-9 10.1128/MCB.24.16.7130-7139.2004 10.1186/s13059-014-0550-8 10.4331/wjbc.v6.i4.281 10.1128/MCB.23.20.7198-7209.2003 10.1038/nrc3278 10.1016/j.mrrev.2010.01.009 10.1186/1471-2105-12-323 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature Limited 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2022. The Author(s), under exclusive licence to Springer Nature Limited. |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature Limited 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2022. The Author(s), under exclusive licence to Springer Nature Limited. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 5PM |
| DOI | 10.1038/s41556-022-00985-x |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest Central Student MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1476-4679 |
| EndPage | 1432 |
| ExternalDocumentID | PMC9977532 36050469 10_1038_s41556_022_00985_x |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) grantid: R35CA197465; P30CA030199 funderid: https://doi.org/10.13039/100000054 – fundername: NCI NIH HHS grantid: R35 CA197465 – fundername: NCI NIH HHS grantid: R01 CA266973 – fundername: NCI NIH HHS grantid: P30 CA030199 – fundername: NCI NIH HHS grantid: R01 CA266828 |
| GroupedDBID | --- .55 .GJ 0R~ 123 29M 36B 39C 3V. 4.4 53G 5BI 5RE 70F 7X7 88A 88E 8AO 8FE 8FH 8FI 8FJ 8R4 8R5 AAEEF AARCD AAYZH AAZLF ABAWZ ABCQX ABDBF ABEFU ABJNI ABLJU ABNNU ABUWG ACBWK ACGFS ACIWK ACNCT ACPRK ACRPL ACUHS ADBBV ADNMO ADQMX AENEX AEUYN AFBBN AFFNX AFKRA AFRAH AFSHS AFWHJ AGAYW AGGDT AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ARMCB ASPBG AVWKF AXYYD AZFZN B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 D0L DB5 DU5 EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA HCIFZ HMCUK HVGLF HZ~ IAO IGS IHR INH INR ISR ITC J5H L-9 L7B LK8 M0L M1P M7P N9A NNMJJ O9- ODYON P2P PQQKQ PROAC PSQYO Q2X QF4 QM4 QN7 QO4 RNS RNT RNTTT SHXYY SIXXV SKT SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP X7M Y6R ZGI ~02 ~8M AAYXX ABFSG ACSTC AEZWR AFANA AFFHD AFHIU AGSTI AHWEU AIXLP ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c474t-3f67f6b1fb277f0cb94df62cc1f96baec5d9bb02bfbb58c913f5aec6a01b899c3 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 27 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000849290000002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1465-7392 1476-4679 |
| IngestDate | Tue Nov 04 02:07:00 EST 2025 Thu Sep 04 18:34:38 EDT 2025 Tue Oct 07 05:18:11 EDT 2025 Wed Feb 19 02:23:42 EST 2025 Sat Nov 29 01:36:21 EST 2025 Tue Nov 18 22:36:40 EST 2025 Fri Feb 21 02:40:09 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| License | 2022. The Author(s), under exclusive licence to Springer Nature Limited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c474t-3f67f6b1fb277f0cb94df62cc1f96baec5d9bb02bfbb58c913f5aec6a01b899c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Current address: Genentech, San Francisco, CA, USA |
| ORCID | 0000-0002-3859-0400 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/9977532 |
| PMID | 36050469 |
| PQID | 2715007146 |
| PQPubID | 45779 |
| PageCount | 11 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_9977532 proquest_miscellaneous_2709741090 proquest_journals_2715007146 pubmed_primary_36050469 crossref_citationtrail_10_1038_s41556_022_00985_x crossref_primary_10_1038_s41556_022_00985_x springer_journals_10_1038_s41556_022_00985_x |
| PublicationCentury | 2000 |
| PublicationDate | 20220900 2022-09-01 2022-09-00 20220901 |
| PublicationDateYYYYMMDD | 2022-09-01 |
| PublicationDate_xml | – month: 9 year: 2022 text: 20220900 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature cell biology |
| PublicationTitleAbbrev | Nat Cell Biol |
| PublicationTitleAlternate | Nat Cell Biol |
| PublicationYear | 2022 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Lieu, Nguyen, Rhyne, Kim (CR4) 2020; 52 Schmiesing (CR22) 2018; 24 Romero (CR42) 2017; 23 Teske (CR32) 2018; 144 Afonyushkin (CR40) 2010; 30 Gu, Eils, Schlesner (CR56) 2016; 32 Wakabayashi (CR33) 2003; 35 Cazzalini, Scovassi, Savio, Stivala, Prosperi (CR39) 2010; 704 He (CR48) 2001; 276 Pathria, Ronai (CR17) 2021; 33 Leandro, Houten (CR20) 2020; 131 Kim (CR19) 2020; 12 Butler, van der Meer, van Leeuwen (CR7) 2021; 32 Ananieva (CR16) 2015; 6 Tan (CR23) 2014; 19 Cantor (CR37) 2017; 169 Kobayashi (CR44) 2004; 24 Nakaya (CR13) 2014; 40 Cruzat, Macedo Rogero, Noel Keane, Curi, Newsholme (CR14) 2018; 10 Wajner, Amaral, Leipnitz, Seminotti (CR25) 2019; 78 Malhotra (CR29) 2010; 38 Palm, Thompson (CR1) 2017; 546 Chaturvedi, Hoffman, Bertino (CR9) 2018; 154 Menegon, Columbano, Giordano (CR34) 2016; 22 Altman, Stine, Dang (CR6) 2016; 16 Sanghvi (CR46) 2019; 178 Kim, Jeong, Surh, Kim (CR41) 2010; 38 Ewels, Magnusson, Lundin, Kaller (CR54) 2016; 32 Cullinan (CR43) 2003; 23 Hoadley (CR57) 2018; 173 Zhu, Thompson (CR2) 2019; 20 Cerami (CR58) 2012; 2 Sun, Chin, Zhang (CR47) 2009; 29 Hirschey, Zhao (CR5) 2015; 14 Dobin (CR52) 2013; 29 He (CR45) 2020; 72 Fallarino (CR21) 2003; 4 Knott (CR10) 2018; 554 Wu (CR36) 2015; 17 Ratnikov (CR50) 2015; 6 Lukey, Katt, Cerione (CR8) 2017; 22 Mungrue, Pagnon, Kohannim, Gargalovic, Lusis (CR38) 2009; 182 Romero (CR31) 2020; 1 Chang (CR12) 2015; 162 Li, Dewey (CR53) 2011; 12 Maddocks (CR11) 2017; 544 Sporn, Liby (CR35) 2012; 12 Hoetzenecker (CR30) 2011; 18 Verma, Ali, Arora, Banerjea (CR51) 2011; 117 Rojo de la Vega, Chapman, Zhang (CR28) 2018; 34 Vander Heiden, DeBerardinis (CR3) 2017; 168 Pathria (CR18) 2019; 21 Zinnanti (CR26) 2006; 129 Biagosch (CR24) 2017; 1863 Seminotti (CR27) 2016; 53 O’Neill, Kishton, Rathmell (CR15) 2016; 16 Fujita, Maeda, Xiao, Srinivasula (CR49) 2011; 108 Love, Huber, Anders (CR55) 2014; 15 M Nakaya (985_CR13) 2014; 40 O Cazzalini (985_CR39) 2010; 704 J Schmiesing (985_CR22) 2018; 24 C Biagosch (985_CR24) 2017; 1863 G Pathria (985_CR18) 2019; 21 R Romero (985_CR42) 2017; 23 W Hoetzenecker (985_CR30) 2011; 18 K Fujita (985_CR49) 2011; 108 MI Love (985_CR55) 2014; 15 P Ewels (985_CR54) 2016; 32 LA O’Neill (985_CR15) 2016; 16 M Butler (985_CR7) 2021; 32 E Cerami (985_CR58) 2012; 2 T Afonyushkin (985_CR40) 2010; 30 N Teske (985_CR32) 2018; 144 SB Cullinan (985_CR43) 2003; 23 KH Kim (985_CR41) 2010; 38 CH He (985_CR48) 2001; 276 Z Sun (985_CR47) 2009; 29 SRV Knott (985_CR10) 2018; 554 B Seminotti (985_CR27) 2016; 53 WJ Zinnanti (985_CR26) 2006; 129 BJ Altman (985_CR6) 2016; 16 MD Hirschey (985_CR5) 2015; 14 IN Mungrue (985_CR38) 2009; 182 M Wajner (985_CR25) 2019; 78 S Verma (985_CR51) 2011; 117 MG Vander Heiden (985_CR3) 2017; 168 B Li (985_CR53) 2011; 12 MB Sporn (985_CR35) 2012; 12 Z Gu (985_CR56) 2016; 32 A Dobin (985_CR52) 2013; 29 S Chaturvedi (985_CR9) 2018; 154 J Leandro (985_CR20) 2020; 131 E Ananieva (985_CR16) 2015; 6 B Ratnikov (985_CR50) 2015; 6 F Fallarino (985_CR21) 2003; 4 A Kobayashi (985_CR44) 2004; 24 JR Cantor (985_CR37) 2017; 169 EL Lieu (985_CR4) 2020; 52 Z Wu (985_CR36) 2015; 17 M Rojo de la Vega (985_CR28) 2018; 34 N Wakabayashi (985_CR33) 2003; 35 KA Hoadley (985_CR57) 2018; 173 CH Chang (985_CR12) 2015; 162 D Malhotra (985_CR29) 2010; 38 J Zhu (985_CR2) 2019; 20 M Tan (985_CR23) 2014; 19 F He (985_CR45) 2020; 72 ODK Maddocks (985_CR11) 2017; 544 VR Sanghvi (985_CR46) 2019; 178 G Pathria (985_CR17) 2021; 33 W Palm (985_CR1) 2017; 546 V Cruzat (985_CR14) 2018; 10 H Kim (985_CR19) 2020; 12 S Menegon (985_CR34) 2016; 22 R Romero (985_CR31) 2020; 1 MJ Lukey (985_CR8) 2017; 22 |
| References_xml | – volume: 2 start-page: 401 year: 2012 end-page: 404 ident: CR58 article-title: The cBio Cancer Genomics Portal: an open platform for exploring multidimensional cancer genomics data publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-12-0095 – volume: 544 start-page: 372 year: 2017 end-page: 376 ident: CR11 article-title: Modulating the therapeutic response of tumours to dietary serine and glycine starvation publication-title: Nature doi: 10.1038/nature22056 – volume: 144 start-page: 285 year: 2018 end-page: 301 ident: CR32 article-title: Chemical hypoxia-induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) publication-title: J. Neurochem. doi: 10.1111/jnc.14270 – volume: 22 start-page: 578 year: 2016 end-page: 593 ident: CR34 article-title: The dual roles of NRF2 in cancer publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2016.05.002 – volume: 546 start-page: 234 year: 2017 end-page: 242 ident: CR1 article-title: Nutrient acquisition strategies of mammalian cells publication-title: Nature doi: 10.1038/nature22379 – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: CR52 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 16 start-page: 553 year: 2016 end-page: 565 ident: CR15 article-title: A guide to immunometabolism for immunologists publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2016.70 – volume: 22 start-page: 796 year: 2017 end-page: 804 ident: CR8 article-title: Targeting amino acid metabolism for cancer therapy publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2016.12.003 – volume: 17 start-page: 47 year: 2015 end-page: 59 ident: CR36 article-title: TPO-induced metabolic reprogramming drives liver metastasis of colorectal cancer CD110 tumor-initiating cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.05.016 – volume: 108 start-page: 1427 year: 2011 end-page: 1432 ident: CR49 article-title: Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1014156108 – volume: 117 start-page: 6600 year: 2011 end-page: 6607 ident: CR51 article-title: Inhibition of β-TrcP-dependent ubiquitination of p53 by HIV-1 Vpu promotes p53-mediated apoptosis in human T cells publication-title: Blood doi: 10.1182/blood-2011-01-333427 – volume: 30 start-page: 1007 year: 2010 end-page: 1013 ident: CR40 article-title: Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.110.204354 – volume: 178 start-page: 807 year: 2019 end-page: 819 e821 ident: CR46 article-title: The oncogenic action of NRF2 depends on de-glycation by fructosamine-3-kinase publication-title: Cell doi: 10.1016/j.cell.2019.07.031 – volume: 4 start-page: 1206 year: 2003 end-page: 1212 ident: CR21 article-title: Modulation of tryptophan catabolism by regulatory T cells publication-title: Nat. Immunol. doi: 10.1038/ni1003 – volume: 38 start-page: 5718 year: 2010 end-page: 5734 ident: CR29 article-title: Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP–seq profiling and network analysis publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq212 – volume: 20 start-page: 436 year: 2019 end-page: 450 ident: CR2 article-title: Metabolic regulation of cell growth and proliferation publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-019-0123-5 – volume: 173 start-page: 291 year: 2018 end-page: 304 e296 ident: CR57 article-title: Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer publication-title: Cell doi: 10.1016/j.cell.2018.03.022 – volume: 33 start-page: 9 year: 2021 end-page: 20 ident: CR17 article-title: Harnessing the co-vulnerabilities of amino acid-restricted cancers publication-title: Cell Metab. doi: 10.1016/j.cmet.2020.12.009 – volume: 40 start-page: 692 year: 2014 end-page: 705 ident: CR13 article-title: Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation publication-title: Immunity doi: 10.1016/j.immuni.2014.04.007 – volume: 32 start-page: 367 year: 2021 end-page: 381 ident: CR7 article-title: Amino acid depletion therapies: starving cancer cells to death publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2021.03.003 – volume: 78 start-page: 215 year: 2019 end-page: 221 ident: CR25 article-title: Pathogenesis of brain damage in glutaric acidemia type I: lessons from the genetic mice model publication-title: Int J. Dev. Neurosci. doi: 10.1016/j.ijdevneu.2019.05.005 – volume: 72 start-page: 1182 year: 2020 end-page: 1195 ident: CR45 article-title: NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly publication-title: J. Hepatol. doi: 10.1016/j.jhep.2020.01.023 – volume: 131 start-page: 14 year: 2020 end-page: 22 ident: CR20 article-title: The lysine degradation pathway: subcellular compartmentalization and enzyme deficiencies publication-title: Mol. Genet. Metab. doi: 10.1016/j.ymgme.2020.07.010 – volume: 129 start-page: 899 year: 2006 end-page: 910 ident: CR26 article-title: A diet-induced mouse model for glutaric aciduria type I publication-title: Brain doi: 10.1093/brain/awl009 – volume: 21 start-page: 1590 year: 2019 end-page: 1603 ident: CR18 article-title: Translational reprogramming marks adaptation to asparagine restriction in cancer publication-title: Nat. Cell Biol. doi: 10.1038/s41556-019-0415-1 – volume: 168 start-page: 657 year: 2017 end-page: 669 ident: CR3 article-title: Understanding the intersections between metabolism and cancer biology publication-title: Cell doi: 10.1016/j.cell.2016.12.039 – volume: 24 start-page: 2946 year: 2018 end-page: 2956 ident: CR22 article-title: Disease-linked glutarylation impairs function and interactions of mitochondrial proteins and contributes to mitochondrial heterogeneity publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.08.014 – volume: 154 start-page: 170 year: 2018 end-page: 173 ident: CR9 article-title: Exploiting methionine restriction for cancer treatment publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2018.05.003 – volume: 32 start-page: 2847 year: 2016 end-page: 2849 ident: CR56 article-title: Complex heatmaps reveal patterns and correlations in multidimensional genomic data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw313 – volume: 32 start-page: 3047 year: 2016 end-page: 3048 ident: CR54 article-title: MultiQC: summarize analysis results for multiple tools and samples in a single report publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw354 – volume: 6 start-page: 7379 year: 2015 end-page: 7389 ident: CR50 article-title: Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma publication-title: Oncotarget doi: 10.18632/oncotarget.3132 – volume: 19 start-page: 605 year: 2014 end-page: 617 ident: CR23 article-title: Lysine glutarylation is a protein posttranslational modification regulated by SIRT5 publication-title: Cell Metab. doi: 10.1016/j.cmet.2014.03.014 – volume: 182 start-page: 466 year: 2009 end-page: 476 ident: CR38 article-title: CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4–ATF3–CHOP cascade publication-title: J. Immunol. doi: 10.4049/jimmunol.182.1.466 – volume: 35 start-page: 238 year: 2003 end-page: 245 ident: CR33 article-title: Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation publication-title: Nat. Genet. doi: 10.1038/ng1248 – volume: 16 start-page: 619 year: 2016 end-page: 634 ident: CR6 article-title: From Krebs to clinic: glutamine metabolism to cancer therapy publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2016.71 – volume: 18 start-page: 128 year: 2011 end-page: 134 ident: CR30 article-title: ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression publication-title: Nat. Med. doi: 10.1038/nm.2557 – volume: 38 start-page: 48 year: 2010 end-page: 59 ident: CR41 article-title: Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp865 – volume: 12 start-page: eaaz5683 year: 2020 ident: CR19 article-title: PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaz5683 – volume: 10 start-page: 1564 year: 2018 ident: CR14 article-title: Glutamine: metabolism and immune function, supplementation and clinical translation publication-title: Nutrients doi: 10.3390/nu10111564 – volume: 1 start-page: 589 year: 2020 end-page: 602 ident: CR31 article-title: Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1 publication-title: Nat. Cancer doi: 10.1038/s43018-020-0071-1 – volume: 554 start-page: 378 year: 2018 end-page: 381 ident: CR10 article-title: Asparagine bioavailability governs metastasis in a model of breast cancer publication-title: Nature doi: 10.1038/nature25465 – volume: 14 start-page: 2308 year: 2015 end-page: 2315 ident: CR5 article-title: Metabolic regulation by lysine malonylation, succinylation, and glutarylation publication-title: Mol. Cell Proteom. doi: 10.1074/mcp.R114.046664 – volume: 52 start-page: 15 year: 2020 end-page: 30 ident: CR4 article-title: Amino acids in cancer publication-title: Exp. Mol. Med doi: 10.1038/s12276-020-0375-3 – volume: 34 start-page: 21 year: 2018 end-page: 43 ident: CR28 article-title: NRF2 and the hallmarks of cancer publication-title: Cancer Cell doi: 10.1016/j.ccell.2018.03.022 – volume: 1863 start-page: 2220 year: 2017 end-page: 2228 ident: CR24 article-title: Elevated glutaric acid levels in Dhtkd1-/Gcdh-double knockout mice challenge our current understanding of lysine metabolism publication-title: Biochim. Biophys. Acta Mol. Basis Dis. doi: 10.1016/j.bbadis.2017.05.018 – volume: 276 start-page: 20858 year: 2001 end-page: 20865 ident: CR48 article-title: Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M101198200 – volume: 23 start-page: 1362 year: 2017 end-page: 1368 ident: CR42 article-title: Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis publication-title: Nat. Med. doi: 10.1038/nm.4407 – volume: 162 start-page: 1229 year: 2015 end-page: 1241 ident: CR12 article-title: Metabolic competition in the tumor microenvironment is a driver of cancer progression publication-title: Cell doi: 10.1016/j.cell.2015.08.016 – volume: 169 start-page: 258 year: 2017 end-page: 272 e217 ident: CR37 article-title: Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase publication-title: Cell doi: 10.1016/j.cell.2017.03.023 – volume: 29 start-page: 2658 year: 2009 end-page: 2672 ident: CR47 article-title: Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01639-08 – volume: 53 start-page: 6459 year: 2016 end-page: 6475 ident: CR27 article-title: Oxidative stress, disrupted energy metabolism, and altered signaling pathways in glutaryl-CoA dehydrogenase knockout mice: potential implications of quinolinic acid toxicity in the neuropathology of glutaric acidemia type I publication-title: Mol. Neurobiol. doi: 10.1007/s12035-015-9548-9 – volume: 24 start-page: 7130 year: 2004 end-page: 7139 ident: CR44 article-title: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.16.7130-7139.2004 – volume: 15 year: 2014 ident: CR55 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 6 start-page: 281 year: 2015 end-page: 289 ident: CR16 article-title: Targeting amino acid metabolism in cancer growth and anti-tumor immune response publication-title: World J. Biol. Chem. doi: 10.4331/wjbc.v6.i4.281 – volume: 23 start-page: 7198 year: 2003 end-page: 7209 ident: CR43 article-title: Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.20.7198-7209.2003 – volume: 12 start-page: 564 year: 2012 end-page: 571 ident: CR35 article-title: NRF2 and cancer: the good, the bad and the importance of context publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3278 – volume: 704 start-page: 12 year: 2010 end-page: 20 ident: CR39 article-title: Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response publication-title: Mutat. Res. doi: 10.1016/j.mrrev.2010.01.009 – volume: 12 start-page: 323 year: 2011 ident: CR53 article-title: RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-12-323 – volume: 4 start-page: 1206 year: 2003 ident: 985_CR21 publication-title: Nat. Immunol. doi: 10.1038/ni1003 – volume: 29 start-page: 15 year: 2013 ident: 985_CR52 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 32 start-page: 2847 year: 2016 ident: 985_CR56 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw313 – volume: 1 start-page: 589 year: 2020 ident: 985_CR31 publication-title: Nat. Cancer doi: 10.1038/s43018-020-0071-1 – volume: 17 start-page: 47 year: 2015 ident: 985_CR36 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.05.016 – volume: 276 start-page: 20858 year: 2001 ident: 985_CR48 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M101198200 – volume: 129 start-page: 899 year: 2006 ident: 985_CR26 publication-title: Brain doi: 10.1093/brain/awl009 – volume: 19 start-page: 605 year: 2014 ident: 985_CR23 publication-title: Cell Metab. doi: 10.1016/j.cmet.2014.03.014 – volume: 33 start-page: 9 year: 2021 ident: 985_CR17 publication-title: Cell Metab. doi: 10.1016/j.cmet.2020.12.009 – volume: 6 start-page: 281 year: 2015 ident: 985_CR16 publication-title: World J. Biol. Chem. doi: 10.4331/wjbc.v6.i4.281 – volume: 20 start-page: 436 year: 2019 ident: 985_CR2 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-019-0123-5 – volume: 23 start-page: 1362 year: 2017 ident: 985_CR42 publication-title: Nat. Med. doi: 10.1038/nm.4407 – volume: 29 start-page: 2658 year: 2009 ident: 985_CR47 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01639-08 – volume: 554 start-page: 378 year: 2018 ident: 985_CR10 publication-title: Nature doi: 10.1038/nature25465 – volume: 32 start-page: 367 year: 2021 ident: 985_CR7 publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2021.03.003 – volume: 24 start-page: 7130 year: 2004 ident: 985_CR44 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.16.7130-7139.2004 – volume: 144 start-page: 285 year: 2018 ident: 985_CR32 publication-title: J. Neurochem. doi: 10.1111/jnc.14270 – volume: 117 start-page: 6600 year: 2011 ident: 985_CR51 publication-title: Blood doi: 10.1182/blood-2011-01-333427 – volume: 22 start-page: 796 year: 2017 ident: 985_CR8 publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2016.12.003 – volume: 38 start-page: 48 year: 2010 ident: 985_CR41 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp865 – volume: 169 start-page: 258 year: 2017 ident: 985_CR37 publication-title: Cell doi: 10.1016/j.cell.2017.03.023 – volume: 2 start-page: 401 year: 2012 ident: 985_CR58 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-12-0095 – volume: 14 start-page: 2308 year: 2015 ident: 985_CR5 publication-title: Mol. Cell Proteom. doi: 10.1074/mcp.R114.046664 – volume: 12 start-page: 564 year: 2012 ident: 985_CR35 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3278 – volume: 35 start-page: 238 year: 2003 ident: 985_CR33 publication-title: Nat. Genet. doi: 10.1038/ng1248 – volume: 6 start-page: 7379 year: 2015 ident: 985_CR50 publication-title: Oncotarget doi: 10.18632/oncotarget.3132 – volume: 178 start-page: 807 year: 2019 ident: 985_CR46 publication-title: Cell doi: 10.1016/j.cell.2019.07.031 – volume: 12 start-page: 323 year: 2011 ident: 985_CR53 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-12-323 – volume: 23 start-page: 7198 year: 2003 ident: 985_CR43 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.20.7198-7209.2003 – volume: 704 start-page: 12 year: 2010 ident: 985_CR39 publication-title: Mutat. Res. doi: 10.1016/j.mrrev.2010.01.009 – volume: 72 start-page: 1182 year: 2020 ident: 985_CR45 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2020.01.023 – volume: 30 start-page: 1007 year: 2010 ident: 985_CR40 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.110.204354 – volume: 32 start-page: 3047 year: 2016 ident: 985_CR54 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw354 – volume: 18 start-page: 128 year: 2011 ident: 985_CR30 publication-title: Nat. Med. doi: 10.1038/nm.2557 – volume: 34 start-page: 21 year: 2018 ident: 985_CR28 publication-title: Cancer Cell doi: 10.1016/j.ccell.2018.03.022 – volume: 154 start-page: 170 year: 2018 ident: 985_CR9 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2018.05.003 – volume: 162 start-page: 1229 year: 2015 ident: 985_CR12 publication-title: Cell doi: 10.1016/j.cell.2015.08.016 – volume: 16 start-page: 553 year: 2016 ident: 985_CR15 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2016.70 – volume: 22 start-page: 578 year: 2016 ident: 985_CR34 publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2016.05.002 – volume: 131 start-page: 14 year: 2020 ident: 985_CR20 publication-title: Mol. Genet. Metab. doi: 10.1016/j.ymgme.2020.07.010 – volume: 168 start-page: 657 year: 2017 ident: 985_CR3 publication-title: Cell doi: 10.1016/j.cell.2016.12.039 – volume: 544 start-page: 372 year: 2017 ident: 985_CR11 publication-title: Nature doi: 10.1038/nature22056 – volume: 78 start-page: 215 year: 2019 ident: 985_CR25 publication-title: Int J. Dev. Neurosci. doi: 10.1016/j.ijdevneu.2019.05.005 – volume: 53 start-page: 6459 year: 2016 ident: 985_CR27 publication-title: Mol. Neurobiol. doi: 10.1007/s12035-015-9548-9 – volume: 24 start-page: 2946 year: 2018 ident: 985_CR22 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.08.014 – volume: 108 start-page: 1427 year: 2011 ident: 985_CR49 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1014156108 – volume: 16 start-page: 619 year: 2016 ident: 985_CR6 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2016.71 – volume: 1863 start-page: 2220 year: 2017 ident: 985_CR24 publication-title: Biochim. Biophys. Acta Mol. Basis Dis. doi: 10.1016/j.bbadis.2017.05.018 – volume: 10 start-page: 1564 year: 2018 ident: 985_CR14 publication-title: Nutrients doi: 10.3390/nu10111564 – volume: 173 start-page: 291 year: 2018 ident: 985_CR57 publication-title: Cell doi: 10.1016/j.cell.2018.03.022 – volume: 40 start-page: 692 year: 2014 ident: 985_CR13 publication-title: Immunity doi: 10.1016/j.immuni.2014.04.007 – volume: 15 year: 2014 ident: 985_CR55 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 52 start-page: 15 year: 2020 ident: 985_CR4 publication-title: Exp. Mol. Med doi: 10.1038/s12276-020-0375-3 – volume: 21 start-page: 1590 year: 2019 ident: 985_CR18 publication-title: Nat. Cell Biol. doi: 10.1038/s41556-019-0415-1 – volume: 12 start-page: eaaz5683 year: 2020 ident: 985_CR19 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaz5683 – volume: 182 start-page: 466 year: 2009 ident: 985_CR38 publication-title: J. Immunol. doi: 10.4049/jimmunol.182.1.466 – volume: 546 start-page: 234 year: 2017 ident: 985_CR1 publication-title: Nature doi: 10.1038/nature22379 – volume: 38 start-page: 5718 year: 2010 ident: 985_CR29 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq212 |
| SSID | ssj0014407 |
| Score | 2.5310514 |
| Snippet | Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the... Tumor dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the... |
| SourceID | pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1422 |
| SubjectTerms | 13 13/1 13/106 13/109 13/2 13/31 13/44 13/89 13/95 14 38 38/39 45 45/41 631/67/1813/1634 631/80/82/23 631/80/86/2366 64 64/60 692/699/67/2327 82 96 Activating transcription factor 3 Addictions Amino Acid Metabolism, Inborn Errors - genetics Amino Acid Metabolism, Inborn Errors - metabolism Apoptosis Biomedical and Life Sciences Brain Diseases, Metabolic - genetics Brain Diseases, Metabolic - metabolism Brain Diseases, Metabolic - pathology Cancer Research Catabolism Cell Biology Cell death Depletion Developmental Biology DNA Glutaryl-CoA dehydrogenase Glutaryl-CoA Dehydrogenase - genetics Glutaryl-CoA Dehydrogenase - metabolism Humans Inactivation Ketoglutarate Dehydrogenase Complex Life Sciences Lysine Melanoma Melanoma - genetics Mitochondria Mitochondrial Proteins Mortality NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Protein turnover Proteins Signal transduction Signaling Stem Cells Tumors |
| Title | NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling |
| URI | https://link.springer.com/article/10.1038/s41556-022-00985-x https://www.ncbi.nlm.nih.gov/pubmed/36050469 https://www.proquest.com/docview/2715007146 https://www.proquest.com/docview/2709741090 https://pubmed.ncbi.nlm.nih.gov/PMC9977532 |
| Volume | 24 |
| WOSCitedRecordID | wos000849290000002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-4679 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0014407 issn: 1465-7392 databaseCode: M7P dateStart: 20220101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4679 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0014407 issn: 1465-7392 databaseCode: BENPR dateStart: 20220101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1476-4679 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0014407 issn: 1465-7392 databaseCode: 7X7 dateStart: 20220101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9QwDLfYBhIvfMMK2ylIvEG0NEmT5mkaY8ck0Ok0Abq3KkmbMWlrb7sObf89SdrrdEzbCy9V1SRtU9uNHf9sA3wQzts9mpVYEUEwt5XBSnCHiZasJEpzFtM1_fouJ5N8NlPTfsNt0cMql__E-KMuGxv2yHeo9KpLiLYRu_NzHKpGBe9qX0JjDTZClgQWoXvTwYvAeQyX9mMyLL0i0AfNEJbvLMJCGuC3FIeUmhm-Wl2Ybmmbt0GT_3hO44I0fvq_U3kGT3pVFO11vPMcHlT1C3jUFae8fgnfJkdjimJkiVdH_cmprpszjQICKQZDoLZBX_e_HCJzjc6aMtYBq4-RnjfztvH3RAEbomPO71fwc3zwY_8Q96UXsOWSt5g5IZ0wqTNUSkesUbx0glqbOiWMrmxWKmMINc6YLLcqZS7zV4UmqfEWnGWvYb1u6moTkBWCV44HYa-4MWWeMmGzXEiquTe30gTS5XcvbJ-XPJTHOC2if5zlRUerwtOqiLQqrhL4OIyZd1k57u29taRD0UvoorghQgLvh2YvW8FhouuquQx9iDe3AnQ1gTcd9YfHMW8Hhr2FBOQKXwwdQt7u1Zb65HfM3628zp0xmsCnJQfdvNbds3h7_yzewWMauTnA37Zgvb24rLbhof3TniwuRrAmZzIe8xFsfD6YTI9GUVb-ApzxFvQ |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAoIL70eggJHgRK0mdmInB4RQy7LVLiuECtpbsJ0YKrXJ0k2h-6f4jXicZKulorceuEWx48SZ8XjG880MwAthnd2jeEGzUIQ0NqWmmYgtDZXkRZipmPt0TV_GcjJJp9Ps4xr87mNhEFbZy0QvqIva4Bn5FpNOdcFoG_Fm9oNi1Sj0rvYlNFq2GJWLX85km7_e3XH0fcnY4N3e9pB2VQWoiWXcUG6FtEJHVjMpbWh0FhdWMGMimwmtSpMUmdYh01brJDVZxG3i7goVRtoZJ4a7cS_BZSfHJULI5HRp4KGfVLbRTAmVTvHognRCnm7NceNGuC-jmMIzoSerG-EZ7fYsSPMvT63fAAc3_7dfdwtudKo2eduujduwVlZ34GpbfHNxF0aTTwNGfOSMU7fdxYGq6kNFEGHlgz1IU5P32ztDohfksC58nbPqG1GzetbUbkyC2Bflc5rfg88XMpP7sF7VVfkQiBEiLm2MwqyMtS7SiAuTpEIyFTtzMgog6umcmy7vOpb_OMi9_5-necsbueON3PNGfhLAq-UzszbryLm9N3q6550EmuenRA_g-bLZyQ50CKmqrI-xT-jMSYTmBvCg5bbl67izc_HsJAC5wofLDpiXfLWl2v_u85NnzqZIOAtgs-fY08_69ywenT-LZ3BtuPdhnI93J6PHcJ35lYRQvw1Yb46Oyydwxfxs9udHT_2aJPD1ojn5D2AwdLI |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6V8lAvPPsIFDASnMDaxHbs5IAQ6rK02mq1QoB6C7YT00ptsnRT6P41fh2286iWit564BYljmPHn8cz9jczAC-5sXaPpDlOQx5ipguFU84MDqWgeZhKRn24pq_7YjJJDg7S6Qr87nxhHK2yk4leUOeVdnvkAyKs6uK8bfjAtLSI6XD0bvYDuwxS7qS1S6fRQGRcLH5Z823-dm9ox_oVIaMPn3d2cZthAGsmWI2p4cJwFRlFhDChVinLDSdaRyblShY6zlOlQqKMUnGi04ia2N7lMoyUNVQ0tfXegJvCBS33tMFpf4LBmHfVtu2NsbBKSOuwE9JkMHeLuKP-EuzCecb4fHlRvKTpXiZs_nVq6xfD0b3_-Tfeh7utCo7eN3PmAawU5UO43STlXDyC8eTTiCDvUWPVcHtxLMvqRCLHvPJOIKiu0Med4S5SC3RS5T7_WfkdyVk1qytbJ3KcGOljna_Dl2vpyQasllVZbAHSnLPCMCfkCqZUnkSU6zjhgkhmzcwogKgb80y38dhdWpDjzPMCaJI1OMksTjKPk-w8gNf9O7MmGsmVpbc7DGStZJpnFwAI4EX_2MoUd1Aky6I6c2VCa2Y6ym4Amw3y-s9Ra_-6PZUAxBIm-wIuXvnyk_Lo0MctT62tEVMSwJsOvRfN-ncvHl_di-dwxwI429-bjJ_AGvGTyjEAt2G1Pj0rnsIt_bM-mp8-89MTwbfrBvIfro59gA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=NRF2+mediates+melanoma+addiction+to+GCDH+by+modulating+apoptotic+signalling&rft.jtitle=Nature+cell+biology&rft.au=Verma%2C+Sachin&rft.au=Crawford%2C+David&rft.au=Khateb%2C+Ali&rft.au=Feng%2C+Yongmei&rft.date=2022-09-01&rft.pub=Nature+Publishing+Group+UK&rft.issn=1465-7392&rft.eissn=1476-4679&rft.volume=24&rft.issue=9&rft.spage=1422&rft.epage=1432&rft_id=info:doi/10.1038%2Fs41556-022-00985-x&rft.externalDocID=10_1038_s41556_022_00985_x |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1465-7392&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1465-7392&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1465-7392&client=summon |