Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells

Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as CD34 + KDR + . The aim of the study was to extensively characterize circulating potential vasculogenic stem...

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Published in:	Stem cell reviews and reports Vol. 17; no. 2; pp. 639 - 651
Main Authors:	Guerin, Coralie L., Guyonnet, Léa, Goudot, Guillaume, Revets, Dominique, Konstantinou, Maria, Chipont, Anna, Chocron, Richard, Blandinieres, Adeline, Khider, Lina, Rancic, Jeanne, Peronino, Christophe, Debuc, Benjamin, Cras, Audrey, Knosp, Camille, Latremouille, Christian, Capel, Antoine, Ollert, Markus, Diehl, Jean-Luc, Jansen, Piet, Planquette, Benjamin, Sanchez, Olivier, Gaussem, Pascale, Mirault, Tristan, Carpentier, Alain, Gendron, Nicolas, Smadja, David M.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.04.2021 Springer Nature B.V
Subjects:	Antigens, CD19 - metabolism Biomedical and Life Sciences Biomedical Engineering and Bioengineering c-Kit protein Cadherins Cardiovascular disease Cardiovascular diseases CD14 antigen CD19 antigen CD34 antigen CD45 antigen Cell Biology Cord blood Coronaviruses COVID-19 COVID-19 - metabolism Endothelial Progenitor Cells - metabolism Endothelial Progenitor Cells - pathology Female Flow cytometry Gene Expression Regulation Heart, Artificial Hemopoiesis Humans Life Sciences Lymphocytes B Male Middle Aged Monocytes Peripheral blood Phenotypes Progenitor cells Proteomics Regenerative Medicine/Tissue Engineering SARS-CoV-2 - metabolism Special Issue on COVID-19 Pandemic and Stem Cells Stem Cells Vascular Endothelial Growth Factor Receptor-2 - metabolism COVID-19 C-kit Bioprosthetic total artificial heart Endothelial progenitors Stem cells VEGFR-2/KDR
ISSN:	2629-3269, 2629-3277, 2629-3277
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Abstract	Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as CD34 + KDR + . The aim of the study was to extensively characterize circulating potential vasculogenic stem cell candidates in two populations of patients with cardiovascular disease by powerful multidimensional single cell complementary cytometric approaches (mass, imaging and flow). We identified cellular candidates in one patient before and after bioprosthetic total artificial heart implantation and results were confirmed in healthy peripheral and cord blood by mass cytometry. We also quantified cellular candidates in 10 patients with different COVID-19 severity. Both C-TAH implantation and COVID-19 at critical stage induce a redistribution of circulating CD34 + and CD19 + sub-populations in peripheral blood. After C-TAH implantation, circulating CD34 + progenitor cells expressed c-Kit stem marker while specific subsets CD34 + CD133 −/+ CD45 −/dim c-Kit + KDR − were mobilized. KDR was only expressed by CD19 + B-lymphocytes and CD14 + monocytes subpopulations in circulation. We confirmed by mass cytometry this KDR expression on CD19 + in healthy peripheral and cord blood, also with a VE-cadherin expression, confirming absence of endothelial lineage marker on CD34 + subtypes. In COVID-19, a significant mobilization of CD34 + c-Kit + KDR − cells was observed between moderate and critical COVID-19 patients regardless CD133 or CD45 expression. In order to better evaluate EPC phenotype, we performed imaging flow cytometry measurements of immature CD34 + KDR + cells in cord blood and showed that, after elimination of non-circular events, those cells were all CD19 + . During COVID-19, a significant mobilization of CD19 + KDR + per million of CD45 + cells was observed between moderate and critical COVID-19 patients regardless of CD34 expression. CD34 + c-Kit + cells are mobilized in both cardiovascular disease described here. KDR cells in peripheral blood are CD19 positive cells and are not classic vasculogenic stem and/or progenitor cells. A better evaluation of c-Kit and KDR expressing cells will lead to the redefinition of circulating endothelial progenitors. Graphical abstract Central illustration figure. Multidimensional proteomic approach of endothelial progenitors demonstrate expression of KDR restricted to CD19 cells. Endothelial progenitor cells (EPCs) are involved in cardiovascular diseases, however their phenotype remains elusive. We elucidated here EPCs phenotype by a deep characterization by multidimensional single cell complementary cytometric approaches after Bioprosthetic total artificial heart implantation and during COVID-19. We showed a redistribution of circulating CD34 + and CD19 + sub-populations in both situations. None of the immature cell population expresses KDR. Mobilized CD34 + expressed c-Kit. Imaging flow cytometry demonstrated that CD34 + KDR + cells, after elimination of non-circular events, are all CD19 + . Our results suggest a new definition of circulating EPCs and emphasize involvement of CD19 cells in cardiovascular disease.
AbstractList	Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as CD34+KDR+. The aim of the study was to extensively characterize circulating potential vasculogenic stem cell candidates in two populations of patients with cardiovascular disease by powerful multidimensional single cell complementary cytometric approaches (mass, imaging and flow). We identified cellular candidates in one patient before and after bioprosthetic total artificial heart implantation and results were confirmed in healthy peripheral and cord blood by mass cytometry. We also quantified cellular candidates in 10 patients with different COVID-19 severity. Both C-TAH implantation and COVID-19 at critical stage induce a redistribution of circulating CD34+ and CD19+ sub-populations in peripheral blood. After C-TAH implantation, circulating CD34+ progenitor cells expressed c-Kit stem marker while specific subsets CD34+CD133-/+CD45-/dimc-Kit+KDR- were mobilized. KDR was only expressed by CD19+ B-lymphocytes and CD14+ monocytes subpopulations in circulation. We confirmed by mass cytometry this KDR expression on CD19+ in healthy peripheral and cord blood, also with a VE-cadherin expression, confirming absence of endothelial lineage marker on CD34+ subtypes. In COVID-19, a significant mobilization of CD34+c-Kit+KDR- cells was observed between moderate and critical COVID-19 patients regardless CD133 or CD45 expression. In order to better evaluate EPC phenotype, we performed imaging flow cytometry measurements of immature CD34+KDR+ cells in cord blood and showed that, after elimination of non-circular events, those cells were all CD19+. During COVID-19, a significant mobilization of CD19+KDR+ per million of CD45+ cells was observed between moderate and critical COVID-19 patients regardless of CD34 expression. CD34+c-Kit+ cells are mobilized in both cardiovascular disease described here. KDR cells in peripheral blood are CD19 positive cells and are not classic vasculogenic stem and/or progenitor cells. A better evaluation of c-Kit and KDR expressing cells will lead to the redefinition of circulating endothelial progenitors.Graphical abstract Central illustration figure. Multidimensional proteomic approach of endothelial progenitors demonstrate expression of KDR restricted to CD19 cells. Endothelial progenitor cells (EPCs) are involved in cardiovascular diseases, however their phenotype remains elusive. We elucidated here EPCs phenotype by a deep characterization by multidimensional single cell complementary cytometric approaches after Bioprosthetic total artificial heart implantation and during COVID-19. We showed a redistribution of circulating CD34+ and CD19+ sub-populations in both situations. None of the immature cell population expresses KDR. Mobilized CD34+ expressed c-Kit. Imaging flow cytometry demonstrated that CD34+KDR+ cells, after elimination of non-circular events, are all CD19+. Our results suggest a new definition of circulating EPCs and emphasize involvement of CD19 cells in cardiovascular disease.Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as CD34+KDR+. The aim of the study was to extensively characterize circulating potential vasculogenic stem cell candidates in two populations of patients with cardiovascular disease by powerful multidimensional single cell complementary cytometric approaches (mass, imaging and flow). We identified cellular candidates in one patient before and after bioprosthetic total artificial heart implantation and results were confirmed in healthy peripheral and cord blood by mass cytometry. We also quantified cellular candidates in 10 patients with different COVID-19 severity. Both C-TAH implantation and COVID-19 at critical stage induce a redistribution of circulating CD34+ and CD19+ sub-populations in peripheral blood. After C-TAH implantation, circulating CD34+ progenitor cells expressed c-Kit stem marker while specific subsets CD34+CD133-/+CD45-/dimc-Kit+KDR- were mobilized. KDR was only expressed by CD19+ B-lymphocytes and CD14+ monocytes subpopulations in circulation. We confirmed by mass cytometry this KDR expression on CD19+ in healthy peripheral and cord blood, also with a VE-cadherin expression, confirming absence of endothelial lineage marker on CD34+ subtypes. In COVID-19, a significant mobilization of CD34+c-Kit+KDR- cells was observed between moderate and critical COVID-19 patients regardless CD133 or CD45 expression. In order to better evaluate EPC phenotype, we performed imaging flow cytometry measurements of immature CD34+KDR+ cells in cord blood and showed that, after elimination of non-circular events, those cells were all CD19+. During COVID-19, a significant mobilization of CD19+KDR+ per million of CD45+ cells was observed between moderate and critical COVID-19 patients regardless of CD34 expression. CD34+c-Kit+ cells are mobilized in both cardiovascular disease described here. KDR cells in peripheral blood are CD19 positive cells and are not classic vasculogenic stem and/or progenitor cells. A better evaluation of c-Kit and KDR expressing cells will lead to the redefinition of circulating endothelial progenitors.Graphical abstract Central illustration figure. Multidimensional proteomic approach of endothelial progenitors demonstrate expression of KDR restricted to CD19 cells. Endothelial progenitor cells (EPCs) are involved in cardiovascular diseases, however their phenotype remains elusive. We elucidated here EPCs phenotype by a deep characterization by multidimensional single cell complementary cytometric approaches after Bioprosthetic total artificial heart implantation and during COVID-19. We showed a redistribution of circulating CD34+ and CD19+ sub-populations in both situations. None of the immature cell population expresses KDR. Mobilized CD34+ expressed c-Kit. Imaging flow cytometry demonstrated that CD34+KDR+ cells, after elimination of non-circular events, are all CD19+. Our results suggest a new definition of circulating EPCs and emphasize involvement of CD19 cells in cardiovascular disease. Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as CD34+KDR+. The aim of the study was to extensively characterize circulating potential vasculogenic stem cell candidates in two populations of patients with cardiovascular disease by powerful multidimensional single cell complementary cytometric approaches (mass, imaging and flow). We identified cellular candidates in one patient before and after bioprosthetic total artificial heart implantation and results were confirmed in healthy peripheral and cord blood by mass cytometry. We also quantified cellular candidates in 10 patients with different COVID-19 severity. Both C-TAH implantation and COVID-19 at critical stage induce a redistribution of circulating CD34+ and CD19+ sub-populations in peripheral blood. After C-TAH implantation, circulating CD34+ progenitor cells expressed c-Kit stem marker while specific subsets CD34+CD133−/+CD45−/dimc-Kit+KDR− were mobilized. KDR was only expressed by CD19+ B-lymphocytes and CD14+ monocytes subpopulations in circulation. We confirmed by mass cytometry this KDR expression on CD19+ in healthy peripheral and cord blood, also with a VE-cadherin expression, confirming absence of endothelial lineage marker on CD34+ subtypes. In COVID-19, a significant mobilization of CD34+c-Kit+KDR− cells was observed between moderate and critical COVID-19 patients regardless CD133 or CD45 expression. In order to better evaluate EPC phenotype, we performed imaging flow cytometry measurements of immature CD34+KDR+ cells in cord blood and showed that, after elimination of non-circular events, those cells were all CD19+. During COVID-19, a significant mobilization of CD19+KDR+ per million of CD45+ cells was observed between moderate and critical COVID-19 patients regardless of CD34 expression. CD34+c-Kit+ cells are mobilized in both cardiovascular disease described here. KDR cells in peripheral blood are CD19 positive cells and are not classic vasculogenic stem and/or progenitor cells. A better evaluation of c-Kit and KDR expressing cells will lead to the redefinition of circulating endothelial progenitors.Graphical abstract Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as CD34 KDR . The aim of the study was to extensively characterize circulating potential vasculogenic stem cell candidates in two populations of patients with cardiovascular disease by powerful multidimensional single cell complementary cytometric approaches (mass, imaging and flow). We identified cellular candidates in one patient before and after bioprosthetic total artificial heart implantation and results were confirmed in healthy peripheral and cord blood by mass cytometry. We also quantified cellular candidates in 10 patients with different COVID-19 severity. Both C-TAH implantation and COVID-19 at critical stage induce a redistribution of circulating CD34 and CD19 sub-populations in peripheral blood. After C-TAH implantation, circulating CD34 progenitor cells expressed c-Kit stem marker while specific subsets CD34 CD133 CD45 c-Kit KDR were mobilized. KDR was only expressed by CD19 B-lymphocytes and CD14 monocytes subpopulations in circulation. We confirmed by mass cytometry this KDR expression on CD19 in healthy peripheral and cord blood, also with a VE-cadherin expression, confirming absence of endothelial lineage marker on CD34 subtypes. In COVID-19, a significant mobilization of CD34 c-Kit KDR cells was observed between moderate and critical COVID-19 patients regardless CD133 or CD45 expression. In order to better evaluate EPC phenotype, we performed imaging flow cytometry measurements of immature CD34 KDR cells in cord blood and showed that, after elimination of non-circular events, those cells were all CD19 . During COVID-19, a significant mobilization of CD19 KDR per million of CD45 cells was observed between moderate and critical COVID-19 patients regardless of CD34 expression. CD34 c-Kit cells are mobilized in both cardiovascular disease described here. KDR cells in peripheral blood are CD19 positive cells and are not classic vasculogenic stem and/or progenitor cells. A better evaluation of c-Kit and KDR expressing cells will lead to the redefinition of circulating endothelial progenitors.Graphical abstract Central illustration figure. Multidimensional proteomic approach of endothelial progenitors demonstrate expression of KDR restricted to CD19 cells. Endothelial progenitor cells (EPCs) are involved in cardiovascular diseases, however their phenotype remains elusive. We elucidated here EPCs phenotype by a deep characterization by multidimensional single cell complementary cytometric approaches after Bioprosthetic total artificial heart implantation and during COVID-19. We showed a redistribution of circulating CD34 and CD19 sub-populations in both situations. None of the immature cell population expresses KDR. Mobilized CD34 expressed c-Kit. Imaging flow cytometry demonstrated that CD34 KDR cells, after elimination of non-circular events, are all CD19 . Our results suggest a new definition of circulating EPCs and emphasize involvement of CD19 cells in cardiovascular disease. Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as CD34 + KDR + . The aim of the study was to extensively characterize circulating potential vasculogenic stem cell candidates in two populations of patients with cardiovascular disease by powerful multidimensional single cell complementary cytometric approaches (mass, imaging and flow). We identified cellular candidates in one patient before and after bioprosthetic total artificial heart implantation and results were confirmed in healthy peripheral and cord blood by mass cytometry. We also quantified cellular candidates in 10 patients with different COVID-19 severity. Both C-TAH implantation and COVID-19 at critical stage induce a redistribution of circulating CD34 + and CD19 + sub-populations in peripheral blood. After C-TAH implantation, circulating CD34 + progenitor cells expressed c-Kit stem marker while specific subsets CD34 + CD133 −/+ CD45 −/dim c-Kit + KDR − were mobilized. KDR was only expressed by CD19 + B-lymphocytes and CD14 + monocytes subpopulations in circulation. We confirmed by mass cytometry this KDR expression on CD19 + in healthy peripheral and cord blood, also with a VE-cadherin expression, confirming absence of endothelial lineage marker on CD34 + subtypes. In COVID-19, a significant mobilization of CD34 + c-Kit + KDR − cells was observed between moderate and critical COVID-19 patients regardless CD133 or CD45 expression. In order to better evaluate EPC phenotype, we performed imaging flow cytometry measurements of immature CD34 + KDR + cells in cord blood and showed that, after elimination of non-circular events, those cells were all CD19 + . During COVID-19, a significant mobilization of CD19 + KDR + per million of CD45 + cells was observed between moderate and critical COVID-19 patients regardless of CD34 expression. CD34 + c-Kit + cells are mobilized in both cardiovascular disease described here. KDR cells in peripheral blood are CD19 positive cells and are not classic vasculogenic stem and/or progenitor cells. A better evaluation of c-Kit and KDR expressing cells will lead to the redefinition of circulating endothelial progenitors. Graphical abstract Central illustration figure. Multidimensional proteomic approach of endothelial progenitors demonstrate expression of KDR restricted to CD19 cells. Endothelial progenitor cells (EPCs) are involved in cardiovascular diseases, however their phenotype remains elusive. We elucidated here EPCs phenotype by a deep characterization by multidimensional single cell complementary cytometric approaches after Bioprosthetic total artificial heart implantation and during COVID-19. We showed a redistribution of circulating CD34 + and CD19 + sub-populations in both situations. None of the immature cell population expresses KDR. Mobilized CD34 + expressed c-Kit. Imaging flow cytometry demonstrated that CD34 + KDR + cells, after elimination of non-circular events, are all CD19 + . Our results suggest a new definition of circulating EPCs and emphasize involvement of CD19 cells in cardiovascular disease. Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as CD34+KDR+. The aim of the study was to extensively characterize circulating potential vasculogenic stem cell candidates in two populations of patients with cardiovascular disease by powerful multidimensional single cell complementary cytometric approaches (mass, imaging and flow). We identified cellular candidates in one patient before and after bioprosthetic total artificial heart implantation and results were confirmed in healthy peripheral and cord blood by mass cytometry. We also quantified cellular candidates in 10 patients with different COVID-19 severity. Both C-TAH implantation and COVID-19 at critical stage induce a redistribution of circulating CD34+ and CD19+ sub-populations in peripheral blood. After C-TAH implantation, circulating CD34+ progenitor cells expressed c-Kit stem marker while specific subsets CD34+CD133−/+CD45−/dimc-Kit+KDR− were mobilized. KDR was only expressed by CD19+ B-lymphocytes and CD14+ monocytes subpopulations in circulation. We confirmed by mass cytometry this KDR expression on CD19+ in healthy peripheral and cord blood, also with a VE-cadherin expression, confirming absence of endothelial lineage marker on CD34+ subtypes. In COVID-19, a significant mobilization of CD34+c-Kit+KDR− cells was observed between moderate and critical COVID-19 patients regardless CD133 or CD45 expression. In order to better evaluate EPC phenotype, we performed imaging flow cytometry measurements of immature CD34+KDR+ cells in cord blood and showed that, after elimination of non-circular events, those cells were all CD19+. During COVID-19, a significant mobilization of CD19+KDR+ per million of CD45+ cells was observed between moderate and critical COVID-19 patients regardless of CD34 expression. CD34+c-Kit+ cells are mobilized in both cardiovascular disease described here. KDR cells in peripheral blood are CD19 positive cells and are not classic vasculogenic stem and/or progenitor cells. A better evaluation of c-Kit and KDR expressing cells will lead to the redefinition of circulating endothelial progenitors. Graphical abstractCentral illustration figure. Multidimensional proteomic approach of endothelial progenitors demonstrate expression of KDR restricted to CD19 cells.Endothelial progenitor cells (EPCs) are involved in cardiovascular diseases, however their phenotype remains elusive. We elucidated here EPCs phenotype by a deep characterization by multidimensional single cell complementary cytometric approaches after Bioprosthetic total artificial heart implantation and during COVID-19. We showed a redistribution of circulating CD34+ and CD19+ sub-populations in both situations. None of the immature cell population expresses KDR. Mobilized CD34+ expressed c-Kit. Imaging flow cytometry demonstrated that CD34+KDR+ cells, after elimination of non-circular events, are all CD19+. Our results suggest a new definition of circulating EPCs and emphasize involvement of CD19 cells in cardiovascular disease.
Author	Gaussem, Pascale Konstantinou, Maria Knosp, Camille Mirault, Tristan Debuc, Benjamin Jansen, Piet Sanchez, Olivier Guyonnet, Léa Rancic, Jeanne Chipont, Anna Khider, Lina Capel, Antoine Peronino, Christophe Smadja, David M. Cras, Audrey Guerin, Coralie L. Revets, Dominique Latremouille, Christian Ollert, Markus Gendron, Nicolas Planquette, Benjamin Diehl, Jean-Luc Goudot, Guillaume Carpentier, Alain Chocron, Richard Blandinieres, Adeline
Author_xml	– sequence: 1 givenname: Coralie L. surname: Guerin fullname: Guerin, Coralie L. organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Cytometry Platform, Institut Curie, Department of Infection and Immunity, Luxembourg Institute of Health – sequence: 2 givenname: Léa surname: Guyonnet fullname: Guyonnet, Léa organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Cytometry Platform, Institut Curie, Department of Infection and Immunity, Luxembourg Institute of Health – sequence: 3 givenname: Guillaume surname: Goudot fullname: Goudot, Guillaume organization: Vascular Medicine Department and Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital, Université de Paris – sequence: 4 givenname: Dominique surname: Revets fullname: Revets, Dominique organization: Department of Infection and Immunity, Luxembourg Institute of Health – sequence: 5 givenname: Maria surname: Konstantinou fullname: Konstantinou, Maria organization: Department of Infection and Immunity, Luxembourg Institute of Health – sequence: 6 givenname: Anna surname: Chipont fullname: Chipont, Anna organization: Department of Infection and Immunity, Luxembourg Institute of Health – sequence: 7 givenname: Richard surname: Chocron fullname: Chocron, Richard organization: PARCC, INSERM, Université de Paris, Emergency Department, AH-HP, Georges Pompidou European Hospital – sequence: 8 givenname: Adeline surname: Blandinieres fullname: Blandinieres, Adeline organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Hematology Department and Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital – sequence: 9 givenname: Lina surname: Khider fullname: Khider, Lina organization: Vascular Medicine Department and Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital, Université de Paris – sequence: 10 givenname: Jeanne surname: Rancic fullname: Rancic, Jeanne organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital – sequence: 11 givenname: Christophe surname: Peronino fullname: Peronino, Christophe organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Hematology Department and Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital – sequence: 12 givenname: Benjamin surname: Debuc fullname: Debuc, Benjamin organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Plastic Surgery Department, AH-HP, Georges Pompidou European Hospital – sequence: 13 givenname: Audrey surname: Cras fullname: Cras, Audrey organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Cell therapy Unit, AP-HP, Saint Louis Hospital – sequence: 14 givenname: Camille surname: Knosp fullname: Knosp, Camille organization: PARCC, INSERM, Université de Paris – sequence: 15 givenname: Christian surname: Latremouille fullname: Latremouille, Christian organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Cardiovascular Surgery Department and Biosurgical Research Laboratory (Carpentier Foundation) AP-HP, Georges Pompidou European Hospital – sequence: 16 givenname: Antoine surname: Capel fullname: Capel, Antoine organization: Carmat SA – sequence: 17 givenname: Markus surname: Ollert fullname: Ollert, Markus organization: Department of Infection and Immunity, Luxembourg Institute of Health – sequence: 18 givenname: Jean-Luc surname: Diehl fullname: Diehl, Jean-Luc organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital, Intensive Care Department and Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital – sequence: 19 givenname: Piet surname: Jansen fullname: Jansen, Piet organization: Carmat SA – sequence: 20 givenname: Benjamin surname: Planquette fullname: Planquette, Benjamin organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital, Respiratory Medicine department and Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital – sequence: 21 givenname: Olivier surname: Sanchez fullname: Sanchez, Olivier organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital, Respiratory Medicine department and Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital – sequence: 22 givenname: Pascale surname: Gaussem fullname: Gaussem, Pascale organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Hematology Department, AH-HP, Georges Pompidou European Hospital – sequence: 23 givenname: Tristan surname: Mirault fullname: Mirault, Tristan organization: PARCC, INSERM, Université de Paris, Vascular Medicine department, AH-HP, Georges Pompidou European Hospital – sequence: 24 givenname: Alain surname: Carpentier fullname: Carpentier, Alain organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Cardiovascular Surgery Department and Biosurgical Research Laboratory (Carpentier Foundation) AP-HP, Georges Pompidou European Hospital – sequence: 25 givenname: Nicolas surname: Gendron fullname: Gendron, Nicolas organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Hematology Department and Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital – sequence: 26 givenname: David M. orcidid: 0000-0001-7731-9202 surname: Smadja fullname: Smadja, David M. email: david.smadja@aphp.fr organization: Innovative Therapies in Haemostasis, INSERM, Université de Paris, Hematology Department and Biosurgical Research Laboratory (Carpentier Foundation), AH-HP, Georges Pompidou European Hospital, European Hospital Georges Pompidou, Inserm UMR-S 1140
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33205351$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1038/nbt.1991 10.1186/s12931-020-01462-5 10.1182/blood-2017-06-792267 10.1016/j.jacc.2017.05.021 10.1186/s13613-020-00716-1 10.1056/NEJMoa043814 10.1056/NEJMoa2015432 10.1016/S0140-6736(20)30937-5 10.1161/CIRCRESAHA.116.309362 10.1111/jth.14968 10.1016/j.cell.2014.04.005 10.1016/j.healun.2017.09.002 10.1155/2016/7162160 10.1161/ATVBAHA.111.244210 10.1111/jth.14462 10.1161/CIRCRESAHA.116.308366 10.1002/cyto.a.23064 10.1160/TH14-09-0748 10.1007/s10456-020-09730-0 10.1152/ajpheart.01146.2002 10.1016/j.jaci.2020.04.013 10.1016/j.jcyt.2013.09.007 10.1007/s12015-020-10043-4 10.1126/science.285.5433.1553 10.1152/physrev.00006.2013 10.1038/nm.3284 10.1038/nbt.4314 10.1016/S0140-6736(20)30251-8 10.1007/s10456-012-9306-9 10.1016/j.it.2012.02.010 10.1007/s12015-020-09987-4
ContentType	Journal Article
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DOI	10.1007/s12015-020-10062-1
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Snippet	Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but...
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SubjectTerms	Antigens, CD19 - metabolism Biomedical and Life Sciences Biomedical Engineering and Bioengineering c-Kit protein Cadherins Cardiovascular disease Cardiovascular diseases CD14 antigen CD19 antigen CD34 antigen CD45 antigen Cell Biology Cord blood Coronaviruses COVID-19 COVID-19 - metabolism Endothelial Progenitor Cells - metabolism Endothelial Progenitor Cells - pathology Female Flow cytometry Gene Expression Regulation Heart, Artificial Hemopoiesis Humans Life Sciences Lymphocytes B Male Middle Aged Monocytes Peripheral blood Phenotypes Progenitor cells Proteomics Regenerative Medicine/Tissue Engineering SARS-CoV-2 - metabolism Special Issue on COVID-19 Pandemic and Stem Cells Stem Cells Vascular Endothelial Growth Factor Receptor-2 - metabolism
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Title	Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells
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