The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention

Background When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their jeopardized neurons. One crucial reason is that we have not identified the molecular mechanisms leading t...

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Bibliographic Details
Published in:	Neurocritical care Vol. 37; no. Suppl 1; pp. 83 - 101
Main Authors:	Andrew, R. David, Hartings, Jed A., Ayata, Cenk, Brennan, K. C., Dawson-Scully, Ken D., Farkas, Eszter, Herreras, Oscar, Kirov, Sergei. A., Müller, Michael, Ollen-Bittle, Nikita, Reiffurth, Clemens, Revah, Omer, Robertson, R. Meldrum, Shuttleworth, C. William, Ullah, Ghanim, Dreier, Jens P.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.06.2022 Springer Nature B.V
Subjects:	Brain death Brain Injuries - therapy Cardiac arrest Cell death Consensus Cortical Spreading Depression - physiology Critical Care Medicine Electrodes Glutamic Acid Hemodynamics Hemorrhage Humans Hypothalamus Intensive Internal Medicine Ischemia Medicine Medicine & Public Health Metabolism Neurology Neurons Neurosurgery Propagation Spreading Cortical Depolarization Stroke Traumatic brain injury Sudden cardiac arrest Brain swelling Stroke Traumatic brain injury Migraine Amyotrophic lateral sclerosis K Huntington's disease Penumbra Modeling Persistent vegetative state Na Ketamine Concussion Ischemia Dendritic beading pump Alzheimer's disease Na+/K+ pump
ISSN:	1541-6933, 1556-0961, 1556-0961
Online Access:	Get full text
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