Agreement in Measures of Macular Perfusion between Optical Coherence Tomography Angiography Machines

We evaluated the agreements in foveal avascular zone (FAZ) area and vessel density (VD) parameters (within the superficial capillary plexus region), between two widely used optical coherence tomography angiography machines. Participants who attended the Singapore Malay Eye Study III between 29th Mar...

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Bibliographic Details
Published in:Scientific reports Vol. 10; no. 1; p. 8345
Main Authors: Dai, Wei, Chee, Miao-Li, Majithia, Shivani, Teo, Cong Ling, Thakur, Sahil, Cheung, Ning, Rim, Tyler Hyungtaek, Tan, Gavin S., Sabanayagam, Charumathi, Cheng, Ching-Yu, Tham, Yih-Chung
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 20.05.2020
Nature Publishing Group
Subjects:
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Aged
Angiography
Case-Control Studies
Correlation coefficient
Cross-Sectional Studies
Eye
Female
Fluorescein Angiography - instrumentation
Fluorescein Angiography - statistics & numerical data
Fovea Centralis - blood supply
Fovea Centralis - diagnostic imaging
Humanities and Social Sciences
Humans
Male
Medical imaging
Middle Aged
multidisciplinary
Perfusion
Reproducibility of Results
Retina
Retinal Vessels - diagnostic imaging
Science
Science (multidisciplinary)
Sexually transmitted diseases
Singapore
STD
Tomography
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - statistics & numerical data
Visual Acuity
Singapore
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:We evaluated the agreements in foveal avascular zone (FAZ) area and vessel density (VD) parameters (within the superficial capillary plexus region), between two widely used optical coherence tomography angiography machines. Participants who attended the Singapore Malay Eye Study III between 29th March and 6th August 2018, were enrolled in this study. Participants underwent fovea-centered 6×6-mm macular cube scan, using both AngioVue and Cirrus HDOCT machines. Scans were analyzed automatically using built-in review software of each machine. 177 eyes (95 participants) without retinal diseases were included for final analysis. Mean FAZ area was 0.38 ± 0.11 mm 2 and 0.30 ± 0.10 mm 2 , based on AngioVue and Cirrus HDOCT, respectively. Mean parafoveal VD was 0.50 ± 0.04 in Angiovue, and 0.43 ± 0.04 in Cirrus HDOCT. Cirrus HDOCT measurements were consistently lower than those by AngioVue, with a mean difference of −0.08 (95% limits of agreement [LOA], −0.30–0.13) mm 2 for FAZ area, and −0.07 (95% LOA, −0.17–0.03) for parafoveal VD. Intraclass correlation coefficients for FAZ area and parafoveal VD were 0.33 and 0.07, respectively. Our data suggest that agreements between AngioVue and Cirrus HDOCT machines were poor to fair, thus alternating use between these two machines may not be recommended especially for follow up evaluations.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-65243-2