Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to improving immunotherapeutic modalities. Here we confirmed pervasive phenotypic, functional and transcriptional diffe...

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Bibliographic Details
Published in:	Nature immunology Vol. 22; no. 8; pp. 1030 - 1041
Main Authors:	Tonnerre, Pierre, Wolski, David, Subudhi, Sonu, Aljabban, Jihad, Hoogeveen, Ruben C., Damasio, Marcos, Drescher, Hannah K., Bartsch, Lea M., Tully, Damien C., Sen, Debattama R., Bean, David J., Brown, Joelle, Torres-Cornejo, Almudena, Robidoux, Maxwell, Kvistad, Daniel, Alatrakchi, Nadia, Cui, Ang, Lieb, David, Cheney, James A., Gustafson, Jenna, Lewis-Ximenez, Lia L., Massenet-Regad, Lucile, Eisenhaure, Thomas, Aneja, Jasneet, Haining, W. Nicholas, Chung, Raymond T., Hacohen, Nir, Allen, Todd M., Kim, Arthur Y., Lauer, Georg M.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.08.2021 Nature Publishing Group
Subjects:	631/250/2152/1566/1571 631/250/2152/1566/2493 631/250/2502/248 631/250/255/2514 692/699/255/234/2513/1551 Antigens Antiviral Agents - therapeutic use Biomedical and Life Sciences Biomedicine CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell differentiation Cell Differentiation - immunology Chronic infection Epitopes - genetics Hepacivirus - immunology Hepatitis Hepatitis C Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology Humans Immunologic Memory - immunology Immunological memory Immunology Infections Infectious Diseases Lymphocytes Lymphocytes T Memory cells Molecular modelling Phenotype Transcription
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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