Cardiovascular risk factors, living and ageing in Halle: the CARLA study

The CARLA study (Cardiovascular Disease, Living and Ageing in Halle) is a longitudinal population-based cohort study of the general population of the city of Halle (Saale), Germany. The primary aim of the cohort was to investigate risk factors for cardiovascular diseases based on comprehensive cardi...

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Vydáno v:	European journal of epidemiology Ročník 37; číslo 1; s. 103 - 116
Hlavní autoři:	Hassan, Lamiaa, Efremov, Ljupcho, Großkopf, Anne, Kartschmit, Nadja, Medenwald, Daniel, Schott, Artjom, Schmidt-Pokrzywniak, Andrea, Lacruz, Maria E., Tiller, Daniel, Kraus, Frank Bernhard, Greiser, Karin H., Haerting, Johannes, Werdan, Karl, Sedding, Daniel, Simm, Andreas, Nuding, Sebastian, Kluttig, Alexander, Mikolajczyk, Rafael
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Dordrecht Springer Netherlands 01.01.2022 Springer Nature B.V
Témata:	Aged Aging Balance Biological Specimen Banks Cardiology Cardiovascular diseases Cardiovascular Diseases - epidemiology Cognition Cohort analysis Cohort Profile Cohort Studies Epidemiology Female Gait Gait recognition Geriatrics Health risks Heart Disease Risk Factors Humans Infectious Diseases Male Medicine Medicine & Public Health Mental health Oncology Phenotyping Population Population studies Population-based studies Public Health Quality assurance Retirement Risk analysis Risk Factors Elderly population Cardiovascular diseases Healthy ageing Population-based cohort study
ISSN:	0393-2990, 1573-7284, 1573-7284
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Abstract	The CARLA study (Cardiovascular Disease, Living and Ageing in Halle) is a longitudinal population-based cohort study of the general population of the city of Halle (Saale), Germany. The primary aim of the cohort was to investigate risk factors for cardiovascular diseases based on comprehensive cardiological phenotyping of study participants and was extended to study factors associated with healthy ageing. In total, 1779 probands (812 women and 967 men, aged 45–83 years) were examined at baseline (2002–2005), with a first and second follow-up performed 4 and 8 years later. The response proportion at baseline was 64.1% and the reparticipation proportion for the first and second follow-up was 86% and 77% respectively. Sixty-four percent of the study participants were in retirement while 25% were full- or partially-employed and 11% were unemployed at the time of the baseline examination. The currently running third follow-up focuses on the assessment of physical and mental health, with an intensive 4 h examination program, including measurement of cardiovascular, neurocognitive, balance and gait parameters. The data collected in the CARLA Study resulted in answering various research questions in over 80 publications, of which two thirds were pooled analyses with other similar population-based studies. Due to the extensiveness of information on risk factors, subclinical conditions and evident diseases, the biobanking concept for the biosamples, the cohort representativeness of an elderly population, and the high level of quality assurance, the CARLA cohort offers a unique platform for further research on important indicators for healthy ageing.
AbstractList	The CARLA study (Cardiovascular Disease, Living and Ageing in Halle) is a longitudinal population-based cohort study of the general population of the city of Halle (Saale), Germany. The primary aim of the cohort was to investigate risk factors for cardiovascular diseases based on comprehensive cardiological phenotyping of study participants and was extended to study factors associated with healthy ageing. In total, 1779 probands (812 women and 967 men, aged 45–83 years) were examined at baseline (2002–2005), with a first and second follow-up performed 4 and 8 years later. The response proportion at baseline was 64.1% and the reparticipation proportion for the first and second follow-up was 86% and 77% respectively. Sixty-four percent of the study participants were in retirement while 25% were full- or partially-employed and 11% were unemployed at the time of the baseline examination. The currently running third follow-up focuses on the assessment of physical and mental health, with an intensive 4 h examination program, including measurement of cardiovascular, neurocognitive, balance and gait parameters. The data collected in the CARLA Study resulted in answering various research questions in over 80 publications, of which two thirds were pooled analyses with other similar population-based studies. Due to the extensiveness of information on risk factors, subclinical conditions and evident diseases, the biobanking concept for the biosamples, the cohort representativeness of an elderly population, and the high level of quality assurance, the CARLA cohort offers a unique platform for further research on important indicators for healthy ageing. The CARLA study (Cardiovascular Disease, Living and Ageing in Halle) is a longitudinal population-based cohort study of the general population of the city of Halle (Saale), Germany. The primary aim of the cohort was to investigate risk factors for cardiovascular diseases based on comprehensive cardiological phenotyping of study participants and was extended to study factors associated with healthy ageing. In total, 1779 probands (812 women and 967 men, aged 45-83 years) were examined at baseline (2002-2005), with a first and second follow-up performed 4 and 8 years later. The response proportion at baseline was 64.1% and the reparticipation proportion for the first and second follow-up was 86% and 77% respectively. Sixty-four percent of the study participants were in retirement while 25% were full- or partially-employed and 11% were unemployed at the time of the baseline examination. The currently running third follow-up focuses on the assessment of physical and mental health, with an intensive 4 h examination program, including measurement of cardiovascular, neurocognitive, balance and gait parameters. The data collected in the CARLA Study resulted in answering various research questions in over 80 publications, of which two thirds were pooled analyses with other similar population-based studies. Due to the extensiveness of information on risk factors, subclinical conditions and evident diseases, the biobanking concept for the biosamples, the cohort representativeness of an elderly population, and the high level of quality assurance, the CARLA cohort offers a unique platform for further research on important indicators for healthy ageing.The CARLA study (Cardiovascular Disease, Living and Ageing in Halle) is a longitudinal population-based cohort study of the general population of the city of Halle (Saale), Germany. The primary aim of the cohort was to investigate risk factors for cardiovascular diseases based on comprehensive cardiological phenotyping of study participants and was extended to study factors associated with healthy ageing. In total, 1779 probands (812 women and 967 men, aged 45-83 years) were examined at baseline (2002-2005), with a first and second follow-up performed 4 and 8 years later. The response proportion at baseline was 64.1% and the reparticipation proportion for the first and second follow-up was 86% and 77% respectively. Sixty-four percent of the study participants were in retirement while 25% were full- or partially-employed and 11% were unemployed at the time of the baseline examination. The currently running third follow-up focuses on the assessment of physical and mental health, with an intensive 4 h examination program, including measurement of cardiovascular, neurocognitive, balance and gait parameters. The data collected in the CARLA Study resulted in answering various research questions in over 80 publications, of which two thirds were pooled analyses with other similar population-based studies. Due to the extensiveness of information on risk factors, subclinical conditions and evident diseases, the biobanking concept for the biosamples, the cohort representativeness of an elderly population, and the high level of quality assurance, the CARLA cohort offers a unique platform for further research on important indicators for healthy ageing. The CARLA study (Cardiovascular Disease, Living and Ageing in Halle) is a longitudinal population-based cohort study of the general population of the city of Halle (Saale), Germany. The primary aim of the cohort was to investigate risk factors for cardiovascular diseases based on comprehensive cardiological phenotyping of study participants and was extended to study factors associated with healthy ageing. In total, 1779 probands (812 women and 967 men, aged 45–83 years) were examined at baseline (2002–2005), with a first and second follow-up performed 4 and 8 years later. The response proportion at baseline was 64.1% and the reparticipation proportion for the first and second follow-up was 86% and 77% respectively. Sixty-four percent of the study participants were in retirement while 25% were full- or partially-employed and 11% were unemployed at the time of the baseline examination. The currently running third follow-up focuses on the assessment of physical and mental health, with an intensive 4 h examination program, including measurement of cardiovascular, neurocognitive, balance and gait parameters. The data collected in the CARLA Study resulted in answering various research questions in over 80 publications, of which two thirds were pooled analyses with other similar population-based studies. Due to the extensiveness of information on risk factors, subclinical conditions and evident diseases, the biobanking concept for the biosamples, the cohort representativeness of an elderly population, and the high level of quality assurance, the CARLA cohort offers a unique platform for further research on important indicators for healthy ageing.
Author	Großkopf, Anne Medenwald, Daniel Greiser, Karin H. Kraus, Frank Bernhard Haerting, Johannes Schott, Artjom Kartschmit, Nadja Tiller, Daniel Sedding, Daniel Hassan, Lamiaa Lacruz, Maria E. Schmidt-Pokrzywniak, Andrea Simm, Andreas Werdan, Karl Kluttig, Alexander Mikolajczyk, Rafael Nuding, Sebastian Efremov, Ljupcho
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Keywords	Elderly population Cardiovascular diseases Healthy ageing Population-based cohort study
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ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_8791893 proquest_miscellaneous_2616287042 proquest_journals_2622860606 pubmed_primary_34978665 crossref_primary_10_1007_s10654_021_00824_7 crossref_citationtrail_10_1007_s10654_021_00824_7 springer_journals_10_1007_s10654_021_00824_7
PublicationCentury	2000
PublicationDate	20220100 2022-01-00 2022-Jan 20220101
PublicationDateYYYYMMDD	2022-01-01
PublicationDate_xml	– month: 1 year: 2022 text: 20220100
PublicationDecade	2020
PublicationPlace	Dordrecht
PublicationPlace_xml	– name: Dordrecht – name: Netherlands
PublicationTitle	European journal of epidemiology
PublicationTitleAbbrev	Eur J Epidemiol
PublicationTitleAlternate	Eur J Epidemiol
PublicationYear	2022
Publisher	Springer Netherlands Springer Nature B.V
Publisher_xml	– name: Springer Netherlands – name: Springer Nature B.V
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SubjectTerms	Aged Aging Balance Biological Specimen Banks Cardiology Cardiovascular diseases Cardiovascular Diseases - epidemiology Cognition Cohort analysis Cohort Profile Cohort Studies Epidemiology Female Gait Gait recognition Geriatrics Health risks Heart Disease Risk Factors Humans Infectious Diseases Male Medicine Medicine & Public Health Mental health Oncology Phenotyping Population Population studies Population-based studies Public Health Quality assurance Retirement Risk analysis Risk Factors
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Title	Cardiovascular risk factors, living and ageing in Halle: the CARLA study
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