Advantages of multi-arm non-randomised sequentially allocated cohort designs for Phase II oncology trials

Efficient trial designs are required to prioritise promising drugs within Phase II trials. Adaptive designs are examples of such designs, but their efficiency is reduced if there is a delay in assessing patient responses to treatment. Motivated by the WIRE trial in renal cell carcinoma (NCT03741426)...

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Bibliographic Details
Published in:	British journal of cancer Vol. 126; no. 2; pp. 204 - 210
Main Authors:	Mossop, Helen, Grayling, Michael J, Gallagher, Ferdia A, Welsh, Sarah J, Stewart, Grant D, Wason, James M S
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.02.2022
Subjects:	Adaptive Clinical Trials as Topic - methods Cancer therapies Clinical trials Clinical Trials, Phase II as Topic - methods Cohort Studies Computer Simulation - standards Efficiency Humans Hypotheses Kidney cancer Medical Oncology - methods Neoplasms - drug therapy Neoplasms - pathology Non-Randomized Controlled Trials as Topic - methods Oncology Patients Recruitment Renal cell carcinoma Research Design - standards Response rates Sample Size Simulation Surgery Treatment Outcome
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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