CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide

There is a strong biological rationale for the augmentation of allogeneic natural killer (NK) cell therapies with a chimeric antigen receptor (CAR) to enhance acute myeloid leukemia (AML) targeting. CD38 is an established immunotherapeutic target in multiple myeloma and under investigation as a targ...

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Bibliographic Details

Published in:	Haematologica (Roma) Vol. 107; no. 2; pp. 437 - 445
Main Authors:	Gurney, Mark, Stikvoort, Arwen, Nolan, Emma, Kirkham-McCarthy, Lucy, Khoruzhenko, Stanislav, Shivakumar, Rama, Zweegman, Sonja, Van de Donk, Niels W.C.J., Mutis, Tuna, Szegezdi, Eva, Sarkar, Subhashis, O’Dwyer, Michael
Format:	Journal Article
Language:	English
Published:	Italy Fondazione Ferrata Storti 01.02.2022 Ferrata Storti Foundation
Subjects:	ADP-ribosyl Cyclase 1 Cell Line, Tumor Cytotoxicity, Immunologic Gene Knockout Techniques Humans Immunotherapy, Adoptive Killer Cells, Natural Leukemia, Myeloid, Acute - therapy Membrane Glycoproteins Receptors, Chimeric Antigen - genetics
ISSN:	0390-6078, 1592-8721, 1592-8721
Online Access:	Get full text
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