POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is overexpressed in many cancers. POLQ inhibitors confer synthetic lethality in HR and Shieldin-deficient cancer cells, which has been proposed to reflect a critical dependence on the DSB repair pathway by MMEJ. Wh...

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Veröffentlicht in:	Molecular cell Jg. 82; H. 24; S. 4664
Hauptverfasser:	Belan, Ondrej, Sebald, Marie, Adamowicz, Marek, Anand, Roopesh, Vancevska, Aleksandra, Neves, Joana, Grinkevich, Vera, Hewitt, Graeme, Segura-Bayona, Sandra, Bellelli, Roberto, Robinson, Helen M R, Higgins, Geoff S, Smith, Graeme C M, West, Stephen C, Rueda, David S, Boulton, Simon J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.12.2022
Schlagworte:	DNA Breaks, Double-Stranded DNA End-Joining Repair DNA Replication - genetics DNA, Single-Stranded - genetics Genomic Instability Humans Neoplasms - genetics Synthetic Lethal Mutations BRCA POLQ post-replicative gap repair replication stress homologous recombination PARP inhibitors BRCA genes PARP
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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