Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation

NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 that is prone to liquid-liquid phase separation (LLPS) in vitro. A predominant class of NUP98 FOs, including NUP98-HOXA9 (NHA9...

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Veröffentlicht in:	Cancer discovery Jg. 12; H. 4; S. 1152
Hauptverfasser:	Chandra, Bappaditya, Michmerhuizen, Nicole L, Shirnekhi, Hazheen K, Tripathi, Swarnendu, Pioso, Brittany J, Baggett, David W, Mitrea, Diana M, Iacobucci, Ilaria, White, Michael R, Chen, Jingjing, Park, Cheon-Gil, Wu, Huiyun, Pounds, Stanley, Medyukhina, Anna, Khairy, Khaled, Gao, Qingsong, Qu, Chunxu, Abdelhamed, Sherif, Gorman, Scott D, Bawa, Simranjot, Maslanka, Carolyn, Kinger, Swati, Dogra, Priyanka, Ferrolino, Mylene C, Di Giacomo, Danika, Mecucci, Cristina, Klco, Jeffery M, Mullighan, Charles G, Kriwacki, Richard W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2022
Schlagworte:	Carcinogenesis Cell Nucleus Child Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Leukemia - genetics Nuclear Pore Complex Proteins - genetics Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Retinoblastoma-Binding Protein 2
ISSN:	2159-8290, 2159-8290
Online-Zugang:	Weitere Angaben
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