Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome

The immunological mechanisms underlying the clinical presentation of SARS-CoV-2 infection and those influencing the disease outcome remain to be defined. Myeloid-derived suppressor cells (MDSC) have been described to be highly increased during COVID-19, however, their role remains elusive. We perfor...

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Veröffentlicht in:	Cell death & disease Jg. 11; H. 10; S. 921
Hauptverfasser:	Sacchi, Alessandra, Grassi, Germana, Bordoni, Veronica, Lorenzini, Patrizia, Cimini, Eleonora, Casetti, Rita, Tartaglia, Eleonora, Marchioni, Luisa, Petrosillo, Nicola, Palmieri, Fabrizio, D’Offizi, Gianpiero, Notari, Stefania, Tempestilli, Massimo, Capobianchi, Maria Rosaria, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, Locatelli, Franco, Antinori, Andrea, Ippolito, Giuseppe, Agrati, Chiara
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 27.10.2020 Springer Nature B.V
Schlagworte:	13/21 38/77 692/420/254 692/699/255/2514 Aged Antibodies Area Under Curve Betacoronavirus - immunology Betacoronavirus - isolation & purification Betacoronavirus - metabolism Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Coronavirus Infections - immunology Coronavirus Infections - mortality Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 Female Humans IL-1β Immunology Interferon-gamma - metabolism Interleukin 6 Interleukin 8 Interleukin-1beta - blood Interleukin-6 - blood Life Sciences Lymphocytes T Male Middle Aged Myeloid-Derived Suppressor Cells - cytology Myeloid-Derived Suppressor Cells - immunology Neutrophils - cytology Neutrophils - immunology Neutrophils - metabolism Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Pandemics Peptides - immunology Peptides - metabolism Plasma levels Pneumonia, Viral - immunology Pneumonia, Viral - mortality Pneumonia, Viral - pathology Pneumonia, Viral - virology Proportional Hazards Models ROC Curve SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Suppressor cells Survival Rate T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Transforming Growth Factor beta - blood Transforming Growth Factor beta - metabolism Tumor necrosis factor-α γ-Interferon
ISSN:	2041-4889, 2041-4889
Online-Zugang:	Volltext
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