Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress. The aim was to investigate the effects of daily coffee consumption on biomarkers of co...
Gespeichert in:
| Veröffentlicht in: | The American journal of clinical nutrition Jg. 91; H. 4; S. 950 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
01.04.2010
|
| Schlagworte: | |
| ISSN: | 1938-3207, 1938-3207 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress.
The aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.
Habitual coffee drinkers (n = 47) refrained for 1 mo from coffee drinking; in the second month they consumed 4 cups of filtered coffee/d and in the third month 8 cups of filtered coffee/d (150 mL/cup). Blood samples were analyzed by gas chromatography-mass spectrometry, bead-based multiplex technology, enzyme-linked immunosorbent assay, or immunonephelometry.
Coffee consumption led to an increase in coffee-derived compounds, mainly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d). No changes were seen for markers of glucose metabolism in an oral-glucose-tolerance test.
Coffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no changes in glucose metabolism were found in our study. Furthermore, many coffee-derived methylxanthines and caffeic acid metabolites appear to be useful as biomarkers of coffee intake. |
|---|---|
| AbstractList | Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress.
The aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.
Habitual coffee drinkers (n = 47) refrained for 1 mo from coffee drinking; in the second month they consumed 4 cups of filtered coffee/d and in the third month 8 cups of filtered coffee/d (150 mL/cup). Blood samples were analyzed by gas chromatography-mass spectrometry, bead-based multiplex technology, enzyme-linked immunosorbent assay, or immunonephelometry.
Coffee consumption led to an increase in coffee-derived compounds, mainly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d). No changes were seen for markers of glucose metabolism in an oral-glucose-tolerance test.
Coffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no changes in glucose metabolism were found in our study. Furthermore, many coffee-derived methylxanthines and caffeic acid metabolites appear to be useful as biomarkers of coffee intake. Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress.BACKGROUNDCoffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress.The aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.OBJECTIVEThe aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.Habitual coffee drinkers (n = 47) refrained for 1 mo from coffee drinking; in the second month they consumed 4 cups of filtered coffee/d and in the third month 8 cups of filtered coffee/d (150 mL/cup). Blood samples were analyzed by gas chromatography-mass spectrometry, bead-based multiplex technology, enzyme-linked immunosorbent assay, or immunonephelometry.DESIGNHabitual coffee drinkers (n = 47) refrained for 1 mo from coffee drinking; in the second month they consumed 4 cups of filtered coffee/d and in the third month 8 cups of filtered coffee/d (150 mL/cup). Blood samples were analyzed by gas chromatography-mass spectrometry, bead-based multiplex technology, enzyme-linked immunosorbent assay, or immunonephelometry.Coffee consumption led to an increase in coffee-derived compounds, mainly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d). No changes were seen for markers of glucose metabolism in an oral-glucose-tolerance test.RESULTSCoffee consumption led to an increase in coffee-derived compounds, mainly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d). No changes were seen for markers of glucose metabolism in an oral-glucose-tolerance test.Coffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no changes in glucose metabolism were found in our study. Furthermore, many coffee-derived methylxanthines and caffeic acid metabolites appear to be useful as biomarkers of coffee intake.CONCLUSIONSCoffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no changes in glucose metabolism were found in our study. Furthermore, many coffee-derived methylxanthines and caffeic acid metabolites appear to be useful as biomarkers of coffee intake. |
| Author | Bidel, Siamak Kempf, Kerstin Erlund, Iris Martin, Stephan Carstensen, Maren Koenig, Wolfgang Kolb, Hubert Tuomilehto, Jaakko Kuha, Suvi Herder, Christian Sundvall, Jouko |
| Author_xml | – sequence: 1 givenname: Kerstin surname: Kempf fullname: Kempf, Kerstin organization: Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich, Heine University Düsseldorf, Düsseldorf, Germany – sequence: 2 givenname: Christian surname: Herder fullname: Herder, Christian – sequence: 3 givenname: Iris surname: Erlund fullname: Erlund, Iris – sequence: 4 givenname: Hubert surname: Kolb fullname: Kolb, Hubert – sequence: 5 givenname: Stephan surname: Martin fullname: Martin, Stephan – sequence: 6 givenname: Maren surname: Carstensen fullname: Carstensen, Maren – sequence: 7 givenname: Wolfgang surname: Koenig fullname: Koenig, Wolfgang – sequence: 8 givenname: Jouko surname: Sundvall fullname: Sundvall, Jouko – sequence: 9 givenname: Siamak surname: Bidel fullname: Bidel, Siamak – sequence: 10 givenname: Suvi surname: Kuha fullname: Kuha, Suvi – sequence: 11 givenname: Jaakko surname: Tuomilehto fullname: Tuomilehto, Jaakko |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20181814$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNUEtLAzEYDFKxDz17k9w8bc2zyXqTUh9Q8KLnJZv9gqm7Sd1khf57F60iMzADM8xh5mgSYgCELilZ8lLIG7OzYckIKZdMS6FP0IyWXBecETX556dontKOEMqEXp2hKSNUjxAz9LlxDmxOODps4-hhlJCGbp99DHhkGmrb-uCtabEPrjVdZ74zExoc8xv0uPfpHTtjc-wTdrHH-bAHzHDjTQ0Z0i02-G8j99605-jUmTbBxVEX6PV-87J-LLbPD0_ru21hhRK5oNY1K060AAaW6oY6JgEUt8oAEQqoUYTXVJZCN1BKZl1NqJGMqpVxtWzYAl3_7O77-DFAylXnk4W2NQHikCrFudRMlWRsXh2bQ91BU-1735n-UP1exb4ATQhu5g |
| CitedBy_id | crossref_primary_10_1016_j_jnutbio_2021_108881 crossref_primary_10_1002_ciuz_201400643 crossref_primary_10_1186_1475_2891_11_42 crossref_primary_10_4162_nrp_2023_17_4_789 crossref_primary_10_1016_j_foodres_2014_05_043 crossref_primary_10_1007_s40200_020_00536_x crossref_primary_10_1007_s13679_022_00490_0 crossref_primary_10_1016_j_foodchem_2011_09_024 crossref_primary_10_3109_19390211_2011_593618 crossref_primary_10_3945_ajcn_115_116095 crossref_primary_10_3390_nu16070924 crossref_primary_10_1016_j_metabol_2013_11_008 crossref_primary_10_1111_eci_12052 crossref_primary_10_1111_joim_12703 crossref_primary_10_1007_s12603_014_0563_8 crossref_primary_10_2337_dc15_0466 crossref_primary_10_3390_ijerph15102100 crossref_primary_10_1093_eurjpc_zwac008 crossref_primary_10_1016_j_jep_2011_02_033 crossref_primary_10_1139_apnm_2018_0880 crossref_primary_10_1016_j_foodres_2014_05_032 crossref_primary_10_1186_1475_2891_10_61 crossref_primary_10_1080_10408398_2018_1489368 crossref_primary_10_1089_jmf_2017_3959 crossref_primary_10_3945_ajcn_110_007922 crossref_primary_10_1016_j_diabres_2012_06_006 crossref_primary_10_1080_09637486_2021_2002829 crossref_primary_10_1002_ptr_7329 crossref_primary_10_1016_j_exger_2013_11_005 crossref_primary_10_1007_s11255_025_04480_8 crossref_primary_10_3390_molecules191119180 crossref_primary_10_1186_s12937_021_00694_5 crossref_primary_10_3390_molecules28186440 crossref_primary_10_1002_biof_1101 crossref_primary_10_1007_s15034_015_0676_0 crossref_primary_10_1016_j_fct_2014_05_017 crossref_primary_10_1111_apt_13620 crossref_primary_10_1053_j_gastro_2017_11_010 crossref_primary_10_1039_D0FO01168A crossref_primary_10_1016_j_nut_2013_01_011 crossref_primary_10_1038_ejcn_2015_98 crossref_primary_10_1007_s13668_013_0052_4 crossref_primary_10_1017_S1368980013000360 crossref_primary_10_1016_j_freeradbiomed_2020_07_020 crossref_primary_10_3390_antiox11020379 crossref_primary_10_2337_dc20_0800 crossref_primary_10_1007_s10654_024_01165_x crossref_primary_10_1017_S0007114520003153 crossref_primary_10_1007_s11130_012_0297_x crossref_primary_10_1007_s00217_015_2618_4 crossref_primary_10_1016_j_nutres_2022_07_010 crossref_primary_10_3390_nu12082325 crossref_primary_10_3233_JAD_150333 crossref_primary_10_3945_jn_110_137323 crossref_primary_10_1007_s00394_022_02946_4 crossref_primary_10_1016_j_jff_2020_103996 crossref_primary_10_1016_j_mayocp_2013_06_020 crossref_primary_10_1016_j_metabol_2012_01_021 crossref_primary_10_1089_caff_2019_0019 crossref_primary_10_1371_journal_pone_0126469 crossref_primary_10_1186_s12986_018_0324_5 crossref_primary_10_1002_cncr_34401 crossref_primary_10_1111_jth_12034 crossref_primary_10_2133_dmpk_DMPK_11_RG_020 crossref_primary_10_1016_j_foodres_2015_12_032 crossref_primary_10_2147_JMDH_S290990 crossref_primary_10_1093_annonc_mdt420 crossref_primary_10_1111_joim_12737 crossref_primary_10_1111_nbu_12278 crossref_primary_10_1007_s10552_014_0364_8 crossref_primary_10_1016_j_conctc_2016_06_013 crossref_primary_10_1007_s00394_010_0136_5 crossref_primary_10_1016_j_brainres_2016_07_028 crossref_primary_10_3390_molecules23123309 crossref_primary_10_1002_mnfr_201300526 crossref_primary_10_1016_j_numecd_2020_07_016 crossref_primary_10_1016_j_phymed_2015_10_018 crossref_primary_10_1038_s41416_021_01277_1 crossref_primary_10_1089_jcr_2014_0013 crossref_primary_10_1161_JAHA_117_007155 crossref_primary_10_1093_carcin_bgac007 crossref_primary_10_3233_JAD_215130 crossref_primary_10_1016_j_foodres_2018_09_020 crossref_primary_10_1038_s41430_024_01438_4 crossref_primary_10_1016_j_mam_2016_12_001 crossref_primary_10_3390_nu10121851 crossref_primary_10_61882_phypha_29_2_171 crossref_primary_10_1007_s00216_013_7288_0 crossref_primary_10_1016_j_jfca_2021_103995 crossref_primary_10_3390_metabo15030163 crossref_primary_10_3390_nu17050806 crossref_primary_10_1111_j_1753_4887_2012_00470_x crossref_primary_10_1017_S0007114518000260 crossref_primary_10_1093_ajcn_nqy295 crossref_primary_10_3390_ijms22041690 crossref_primary_10_1016_j_watres_2021_116833 crossref_primary_10_1111_ijcp_13983 crossref_primary_10_2217_dmt_11_23 crossref_primary_10_1007_s00394_014_0701_4 crossref_primary_10_3390_antiox14030285 crossref_primary_10_1186_s12884_016_0851_x crossref_primary_10_1007_s00394_013_0603_x crossref_primary_10_3390_nu13010273 crossref_primary_10_3945_ajcn_113_080317 crossref_primary_10_1016_j_numecd_2018_05_007 crossref_primary_10_3390_nu13062114 crossref_primary_10_1016_j_jff_2012_05_010 crossref_primary_10_3389_fnut_2021_739359 crossref_primary_10_2147_JMDH_S276395 crossref_primary_10_1016_j_nut_2020_111045 crossref_primary_10_1111_dom_12155 crossref_primary_10_1080_10408398_2025_2474177 crossref_primary_10_3945_ajcn_2010_29876 crossref_primary_10_1017_S0007114511005460 crossref_primary_10_3390_antiox13121455 crossref_primary_10_3390_nu13072399 crossref_primary_10_1093_jnci_djr151 crossref_primary_10_1007_s10787_023_01315_9 crossref_primary_10_1016_j_numecd_2021_05_014 crossref_primary_10_3390_ijms22116110 crossref_primary_10_3390_nu15183910 crossref_primary_10_1002_mnfr_201200222 crossref_primary_10_1051_bioconf_20202600049 crossref_primary_10_1016_j_lfs_2015_08_005 crossref_primary_10_1155_2011_146865 crossref_primary_10_3390_nu12061842 crossref_primary_10_1007_s10654_019_00524_3 crossref_primary_10_1007_s00125_014_3457_8 crossref_primary_10_1515_pjfns_2015_0048 crossref_primary_10_1002_mnfr_201400897 crossref_primary_10_1016_j_ejphar_2020_173561 crossref_primary_10_1016_j_cdnut_2024_102095 crossref_primary_10_1007_s00394_014_0763_3 crossref_primary_10_1016_j_foodchem_2020_128045 crossref_primary_10_1093_jn_nxy075 crossref_primary_10_1111_ijfs_16617 crossref_primary_10_1016_j_jtcme_2018_01_001 crossref_primary_10_1515_CCLM_2011_652 crossref_primary_10_3390_nu9030276 crossref_primary_10_1155_2017_6723931 crossref_primary_10_1007_s00394_019_02009_1 crossref_primary_10_3390_nu13113976 crossref_primary_10_1016_j_numecd_2020_08_017 crossref_primary_10_1093_annonc_mdt105 crossref_primary_10_1177_1359105317723452 crossref_primary_10_1016_j_jff_2015_11_027 crossref_primary_10_1038_s41598_018_36291_6 crossref_primary_10_1007_s10552_013_0234_9 crossref_primary_10_1016_j_jep_2021_114778 crossref_primary_10_1017_S002966511600094X crossref_primary_10_1038_nutd_2012_6 crossref_primary_10_1016_j_maturitas_2013_02_002 crossref_primary_10_1007_s00394_018_1726_x crossref_primary_10_1016_j_jnutbio_2023_109336 crossref_primary_10_1002_fsn3_2617 crossref_primary_10_1155_2012_207426 crossref_primary_10_1002_mnfr_201200721 crossref_primary_10_3389_fphar_2022_806010 crossref_primary_10_1111_j_1747_0080_2012_01601_x crossref_primary_10_1016_j_fct_2017_04_002 crossref_primary_10_1093_aje_kwr226 crossref_primary_10_1111_1471_0528_12930 crossref_primary_10_1155_2013_782461 crossref_primary_10_3945_ajcn_114_089987 crossref_primary_10_1007_s10654_013_9834_7 crossref_primary_10_1016_j_fbio_2025_107317 crossref_primary_10_1016_j_nut_2013_11_020 crossref_primary_10_3945_ajcn_110_010926 crossref_primary_10_1093_aje_kwu194 crossref_primary_10_1080_10408398_2020_1779175 crossref_primary_10_3390_nu13030920 crossref_primary_10_1007_s00394_021_02650_9 crossref_primary_10_1111_dme_12469 crossref_primary_10_32706_tusbid_542906 crossref_primary_10_3390_antiox12030554 crossref_primary_10_1016_j_jff_2012_12_002 crossref_primary_10_1093_jn_nxaa365 crossref_primary_10_1038_hr_2011_195 crossref_primary_10_1371_journal_pone_0094463 crossref_primary_10_3390_nu13051394 crossref_primary_10_1016_j_jphs_2015_01_003 crossref_primary_10_1039_D0FO01674H crossref_primary_10_1016_j_clnu_2023_02_024 crossref_primary_10_1002_mnfr_201200021 crossref_primary_10_3389_fnut_2024_1390309 crossref_primary_10_3390_ijms24065521 crossref_primary_10_1007_s12161_017_0847_9 crossref_primary_10_1093_advances_nmaa177 crossref_primary_10_1007_s11886_013_0403_1 crossref_primary_10_1016_j_abb_2011_06_009 crossref_primary_10_1136_heartjnl_2014_306663 crossref_primary_10_4161_cc_28929 crossref_primary_10_1080_10408398_2011_630153 crossref_primary_10_1080_10408398_2021_1963207 crossref_primary_10_3945_jn_115_224774 crossref_primary_10_3390_nu17172834 crossref_primary_10_1016_j_phrs_2022_106596 crossref_primary_10_1111_j_1365_2362_2010_02455_x crossref_primary_10_1007_s00063_010_1156_x crossref_primary_10_2188_jea_JE20120053 crossref_primary_10_3390_nu11051102 crossref_primary_10_1002_mnfr_202400338 crossref_primary_10_1108_00346651311327891 crossref_primary_10_3945_ajcn_112_044248 crossref_primary_10_1186_s12937_016_0220_7 crossref_primary_10_1080_10408398_2017_1386159 crossref_primary_10_1016_j_nut_2013_01_003 crossref_primary_10_1053_j_gastro_2018_02_006 crossref_primary_10_1080_09637486_2020_1862069 crossref_primary_10_5812_hepatmon_45609 crossref_primary_10_1016_j_jnutbio_2015_08_028 crossref_primary_10_1016_j_jand_2025_05_012 crossref_primary_10_1093_ajcn_nqz306 crossref_primary_10_1161_JAHA_118_008814 crossref_primary_10_2174_1381612829666221213101827 crossref_primary_10_3390_ijms26125544 crossref_primary_10_1093_nutrit_nuy014 crossref_primary_10_1093_ajcn_nqab348 crossref_primary_10_1161_STROKEAHA_110_603787 crossref_primary_10_1093_advances_nmab054 crossref_primary_10_1017_jns_2014_19 crossref_primary_10_1089_caff_2018_0007 crossref_primary_10_3390_molecules21080979 crossref_primary_10_1186_1475_2891_10_93 crossref_primary_10_3945_ajcn_2010_29598 crossref_primary_10_1016_j_amjcard_2010_12_035 crossref_primary_10_1039_C4FO00042K crossref_primary_10_1016_j_bbr_2014_01_051 crossref_primary_10_1007_s00210_012_0807_2 crossref_primary_10_5812_jjhr_60437 crossref_primary_10_1016_j_jacc_2013_06_035 crossref_primary_10_1002_ptr_7580 crossref_primary_10_1007_s10753_018_0946_9 crossref_primary_10_1186_s12916_024_03817_x crossref_primary_10_1155_2022_1735204 crossref_primary_10_1108_NFS_05_2017_0100 crossref_primary_10_1016_j_euo_2022_07_008 crossref_primary_10_1053_j_gastro_2015_02_007 crossref_primary_10_1016_j_nutres_2013_07_008 crossref_primary_10_1007_s00394_016_1316_8 crossref_primary_10_3390_beverages5010011 crossref_primary_10_1016_j_nut_2018_06_026 crossref_primary_10_1016_j_arr_2024_102581 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.3945/ajcn.2009.28548 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Diet & Clinical Nutrition |
| EISSN | 1938-3207 |
| ExternalDocumentID | 20181814 |
| Genre | Clinical Trial, Phase III Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -ET -~X ..I .55 .GJ 0R~ 1HT 23M 2FS 2WC 3O- 4.4 48X 53G 5GY 5RE 5VS 6J9 85S 8R4 8R5 A8Z AABZA AACZT AAGQS AAHBH AAIKC AAJQQ AALRI AAMNW AAPGJ AAPQZ AAUQX AAUTI AAVAP AAWDT AAWTL AAXUO AAYOK ABBTP ABDNZ ABDPE ABJNI ABLJU ABOCM ABPTD ABSAR ABWST ACFRR ACGFO ACGFS ACGOD ACNCT ACPRK ACPVT ACUFI ACUTJ ADBBV ADGZP ADHUB ADRTK ADUKH ADVEK ADVLN AEGXH AENEX AETBJ AFFDN AFFNX AFFZL AFJKZ AFOFC AFRAH AFXAL AGINJ AGKRT AGNAY AGQXC AGUTN AHMBA AI. AIAGR AITUG AJEEA AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ ANFBD AQDSO AQKUS BAWUL BAYMD BCRHZ BKOMP BTRTY C1A CDBKE CGR CUY CVF DAKXR DIK E3Z EBS ECM EIF EIHJH EJD ENERS EX3 F5P F9R FDB FECEO FLUFQ FOEOM FOTVD FQBLK FRP GAUVT GJXCC GX1 H13 HF~ HZ~ IH2 J5H KBUDW KOP KQ8 KSI KSN L7B LPU MBLQV MHKGH MV1 MVM N4W NEJ NHB NHCRO NOMLY NOYVH NPM NVLIB O9- ODMLO OHT OK1 OVD P2P P6G PCD PQQKQ PRG Q2X R0Z RHF RHI RNS ROL ROX SJN SV3 TCN TEORI TMA TNT TR2 TWZ UBH UHB UKR VH1 VXZ W2D W8F WH7 WHG WOQ WOW X7M XOL XSW YBU YHG YOJ YQJ YR5 YRY YSK YV5 YYQ YZZ Z5M ZCA ZCG ZGI ZUP ZXP ~KM 7X8 ACVFH ADCNI AEUPX AFPUW AIGII AKBMS AKYEP EFKBS |
| ID | FETCH-LOGICAL-c474t-1cfd63084e2ec18d1f25ee73c7ae047e1a703b15948de952cfb01a52176afb5d2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 288 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000275802400016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1938-3207 |
| IngestDate | Mon Sep 29 05:24:45 EDT 2025 Wed Feb 19 02:24:39 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c474t-1cfd63084e2ec18d1f25ee73c7ae047e1a703b15948de952cfb01a52176afb5d2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 20181814 |
| PQID | 733582790 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_733582790 pubmed_primary_20181814 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-04-01 |
| PublicationDateYYYYMMDD | 2010-04-01 |
| PublicationDate_xml | – month: 04 year: 2010 text: 2010-04-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | The American journal of clinical nutrition |
| PublicationTitleAlternate | Am J Clin Nutr |
| PublicationYear | 2010 |
| SSID | ssj0012486 |
| Score | 2.4874234 |
| Snippet | Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 950 |
| SubjectTerms | Adiponectin - blood Adult Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Apolipoproteins - blood Biomarkers - blood Blood Glucose - metabolism Caffeic Acids - blood Caffeic Acids - metabolism Caffeine - blood Chlorogenic Acid - blood Cholesterol - blood Coffee - chemistry Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Dinoprost - analogs & derivatives Dinoprost - blood Female Humans Inflammation - drug therapy Interleukin-18 - blood Lipids - blood Male Middle Aged Plant Preparations - pharmacology Plant Preparations - therapeutic use Risk Factors Single-Blind Method |
| Title | Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/20181814 https://www.proquest.com/docview/733582790 |
| Volume | 91 |
| WOSCitedRecordID | wos000275802400016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEA7qinjxsb7WF3MQb2X7TuJFRF08uIsHhb0taTIFRVq1u_5-Z_rQk3gQSptLQ0m-Tqcz830jxFmSaqSt5Yi7dh5Zv8xTKo09ZC0rrV2AaU0UvpeTiZpO9UNbm1O1ZZWdTawNtSstx8iHMmJOp9T-5du7x02jOLnadtBYFr2IPBkGtZz-JBHCuG70SC6K8qLQl42yT6TjZGhebNGIVTKDUP3uXtafmdHmPx9wS2y0_iVcNYDYFktY9MXg5hnncA6tCOgrTDoN_r5YG7fZ9R3x2UgZV1DmYEsaI12YoVmbFaCjWmQdlRIImoSmhvkIpnBQc7mAa9Wh7eID5BEDB3khhC7IewEGvueoe4bsiqfR7eP1ndf2ZfBsLOO5F9jcpZGvYgzRBsoFeZggyshKg34sMTBkRrKAhWAc6iS0eeYHhvwEmZo8S1y4J1aKssADAS5i7mtKSMKMf9SVczrKaP4sl76RaiCgW-wZ4Z6TGabAclHNvpd7IPabDZu9Nfocs5BFyFQQH_5985FYb8oBuBTnWPRyeufxRKzaz_lz9XFa44nOk4fxF7H31lw |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+coffee+consumption+on+subclinical+inflammation+and+other+risk+factors+for+type+2+diabetes%3A+a+clinical+trial&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.au=Kempf%2C+Kerstin&rft.au=Herder%2C+Christian&rft.au=Erlund%2C+Iris&rft.au=Kolb%2C+Hubert&rft.date=2010-04-01&rft.issn=1938-3207&rft.eissn=1938-3207&rft.volume=91&rft.issue=4&rft.spage=950&rft_id=info:doi/10.3945%2Fajcn.2009.28548&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1938-3207&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1938-3207&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1938-3207&client=summon |