MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

The PSMC3IP-MND1 heterodimer promotes meiotic D loop formation before DNA strand exchange. In genome-scale CRISPR-Cas9 mutagenesis and interference screens in mitotic cells, depletion of PSMC3IP or MND1 causes sensitivity to poly (ADP-Ribose) polymerase inhibitors (PARPi) used in cancer treatment. P...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 42; H. 5; S. 112484
Hauptverfasser:	Zelceski, Anabel, Francica, Paola, Lingg, Lea, Mutlu, Merve, Stok, Colin, Liptay, Martin, Alexander, John, Baxter, Joseph S., Brough, Rachel, Gulati, Aditi, Haider, Syed, Raghunandan, Maya, Song, Feifei, Sridhar, Sandhya, Forment, Josep V., O’Connor, Mark J., Davies, Barry R., van Vugt, Marcel A.T.M., Krastev, Dragomir B., Pettitt, Stephen J., Tutt, Andrew N.J., Rottenberg, Sven, Lord, Christopher J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 30.05.2023 Elsevier
Schlagworte:	CP: Molecular biology DNA repair MND1 PARP inhibitor PSMC3IP PSMC3IP and PARPi sensitivity PSMC3IP CP: Molecular biology MND1 PSMC3IP and PARPi sensitivity DNA repair PARP inhibitor
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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