A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression

Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features transdifferentiation of tissue-resident pancreatic stellate cells (PSC) into activated cancer-associated fibroblasts, a process induced by PDAC...

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Bibliographic Details
Published in:	Cancer discovery Vol. 9; no. 5; p. 617
Main Authors:	Auciello, Francesca R, Bulusu, Vinay, Oon, Chet, Tait-Mulder, Jacqueline, Berry, Mark, Bhattacharyya, Sohinee, Tumanov, Sergey, Allen-Petersen, Brittany L, Link, Jason, Kendsersky, Nicholas D, Vringer, Esmee, Schug, Michelle, Novo, David, Hwang, Rosa F, Evans, Ronald M, Nixon, Colin, Dorrell, Craig, Morton, Jennifer P, Norman, Jim C, Sears, Rosalie C, Kamphorst, Jurre J, Sherman, Mara H
Format:	Journal Article
Language:	English
Published:	United States 01.05.2019
Subjects:	Animals Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Movement Cell Proliferation Disease Models, Animal Disease Progression Female Humans Lysophosphatidylcholines - metabolism Male Mice, Inbred C57BL Mice, Nude Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic Stellate Cells - metabolism Pancreatic Stellate Cells - pathology Phosphoric Diester Hydrolases - metabolism Signal Transduction Stromal Cells - metabolism Stromal Cells - pathology Tumor Cells, Cultured Xenograft Model Antitumor Assays
ISSN:	2159-8290, 2159-8290
Online Access:	Get more information
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