Assessment of the Pharmacokinetics and Safety of Spesolimab, a Humanised Anti-interleukin-36 Receptor Monoclonal Antibody, in Healthy Non-Japanese and Japanese Subjects: Results from Phase I Clinical Studies

Background and Objective The interleukin-36 signalling pathway is associated with pathogenesis of a number of inflammatory diseases. Spesolimab is a selective, humanised, IgG1 antibody that targets the interleukin-36 receptor. We aimed to evaluate the pharmacokinetics, safety and tolerability of sin...

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Bibliographic Details
Published in:	Clinical pharmacokinetics Vol. 61; no. 12; pp. 1771 - 1787
Main Authors:	Joseph, David, Thoma, Christian, Haeufel, Thomas, Li, Xiujiang
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.12.2022 Springer Nature B.V
Subjects:	Antibodies Cytokines Dermatitis Dose-Response Relationship, Drug Double-Blind Method Drug dosages Half-Life Healthy Volunteers Humans Inflammatory diseases Infusions, Intravenous Injections, Subcutaneous Internal Medicine Laboratories Medicine Medicine & Public Health Monoclonal antibodies NCT NCT02525679 NCT02852824 NCT03100903 NCT03123094 NCT03617835 Original Original Research Article Pathogenesis Pharmacokinetics Pharmacology Pharmacology/Toxicology Pharmacotherapy Plasma United States > US
ISSN:	0312-5963, 1179-1926, 1179-1926
Online Access:	Get full text
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