Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1
Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to P...
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| Vydané v: | iScience Ročník 25; číslo 7; s. 104599 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
Elsevier Inc
15.07.2022
Elsevier |
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| ISSN: | 2589-0042, 2589-0042 |
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| Abstract | Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation remains overlooked. Here, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors (RLRs) upon infection by different RNA viruses. In each infection, several RNAs transcribed by RNA polymerase III (Pol3) specifically engaged RLRs, particularly the family of Y RNAs. Sensing of Y RNAs was dependent on their mimicking of viral secondary structure and their 5′-triphosphate extremity. Further, we found that HIV-1 triggered a VPR-dependent downregulation of RNA triphosphatase DUSP11 in vitro and in vivo, inducing a transcriptome-wide change of cellular RNA 5′-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection.
[Display omitted]
•Y RNAs and other POL3 transcripts are RLRs ligands during RNA virus infections•Y RNA immunogenicity depends on their 5′-PPP and viral-mimicry secondary structure•Development of a novel sequencing approach to measure 5′-PPP status of RNA•HIV-1 VPR triggers DUSP11 downregulation and modulates host 5′-PPP transcriptome
Biological sciences; Immunology; Transcriptomics |
|---|---|
| AbstractList | Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation remains overlooked. Here, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors (RLRs) upon infection by different RNA viruses. In each infection, several RNAs transcribed by RNA polymerase III (Pol3) specifically engaged RLRs, particularly the family of Y RNAs. Sensing of Y RNAs was dependent on their mimicking of viral secondary structure and their 5′-triphosphate extremity. Further, we found that HIV-1 triggered a VPR-dependent downregulation of RNA triphosphatase DUSP11 in vitro and in vivo, inducing a transcriptome-wide change of cellular RNA 5′-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection.
•
Y RNAs and other POL3 transcripts are RLRs ligands during RNA virus infections
•
Y RNA immunogenicity depends on their 5′-PPP and viral-mimicry secondary structure
•
Development of a novel sequencing approach to measure 5′-PPP status of RNA
•
HIV-1 VPR triggers DUSP11 downregulation and modulates host 5′-PPP transcriptome
Biological sciences; Immunology; Transcriptomics Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation remains overlooked. Here, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors (RLRs) upon infection by different RNA viruses. In each infection, several RNAs transcribed by RNA polymerase III (Pol3) specifically engaged RLRs, particularly the family of Y RNAs. Sensing of Y RNAs was dependent on their mimicking of viral secondary structure and their 5′-triphosphate extremity. Further, we found that HIV-1 triggered a VPR-dependent downregulation of RNA triphosphatase DUSP11 in vitro and in vivo, inducing a transcriptome-wide change of cellular RNA 5′-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection. Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation remains overlooked. Here, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors (RLRs) upon infection by different RNA viruses. In each infection, several RNAs transcribed by RNA polymerase III (Pol3) specifically engaged RLRs, particularly the family of Y RNAs. Sensing of Y RNAs was dependent on their mimicking of viral secondary structure and their 5′-triphosphate extremity. Further, we found that HIV-1 triggered a VPR-dependent downregulation of RNA triphosphatase DUSP11 in vitro and in vivo, inducing a transcriptome-wide change of cellular RNA 5′-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection. Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation remains overlooked. Here, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors (RLRs) upon infection by different RNA viruses. In each infection, several RNAs transcribed by RNA polymerase III (Pol3) specifically engaged RLRs, particularly the family of Y RNAs. Sensing of Y RNAs was dependent on their mimicking of viral secondary structure and their 5'-triphosphate extremity. Further, we found that HIV-1 triggered a VPR-dependent downregulation of RNA triphosphatase DUSP11 and , inducing a transcriptome-wide change of cellular RNA 5'-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection. Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation remains overlooked. Here, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors (RLRs) upon infection by different RNA viruses. In each infection, several RNAs transcribed by RNA polymerase III (Pol3) specifically engaged RLRs, particularly the family of Y RNAs. Sensing of Y RNAs was dependent on their mimicking of viral secondary structure and their 5'-triphosphate extremity. Further, we found that HIV-1 triggered a VPR-dependent downregulation of RNA triphosphatase DUSP11 in vitro and in vivo, inducing a transcriptome-wide change of cellular RNA 5'-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection.Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation remains overlooked. Here, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors (RLRs) upon infection by different RNA viruses. In each infection, several RNAs transcribed by RNA polymerase III (Pol3) specifically engaged RLRs, particularly the family of Y RNAs. Sensing of Y RNAs was dependent on their mimicking of viral secondary structure and their 5'-triphosphate extremity. Further, we found that HIV-1 triggered a VPR-dependent downregulation of RNA triphosphatase DUSP11 in vitro and in vivo, inducing a transcriptome-wide change of cellular RNA 5'-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection. Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation remains overlooked. Here, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors (RLRs) upon infection by different RNA viruses. In each infection, several RNAs transcribed by RNA polymerase III (Pol3) specifically engaged RLRs, particularly the family of Y RNAs. Sensing of Y RNAs was dependent on their mimicking of viral secondary structure and their 5′-triphosphate extremity. Further, we found that HIV-1 triggered a VPR-dependent downregulation of RNA triphosphatase DUSP11 in vitro and in vivo, inducing a transcriptome-wide change of cellular RNA 5′-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection. [Display omitted] •Y RNAs and other POL3 transcripts are RLRs ligands during RNA virus infections•Y RNA immunogenicity depends on their 5′-PPP and viral-mimicry secondary structure•Development of a novel sequencing approach to measure 5′-PPP status of RNA•HIV-1 VPR triggers DUSP11 downregulation and modulates host 5′-PPP transcriptome Biological sciences; Immunology; Transcriptomics |
| ArticleNumber | 104599 |
| Author | van der Werf, Sylvie Balan, Sreekumar Jouvenet, Nolwenn Chauveau, Lise Tangy, Frédéric Gopal, Ramya Bhardwaj, Nina Komarova, Anastassia V. Sismeiro, Odile Markowitz, Martin Chazal, Maxime Greenbaum, Benjamin D. Rahou, Yannis McClain, Christopher Legendre, Rachel Najburg, Valérie Beauclair, Guillaume Varet, Hugo Schwartz, Olivier Solovyov, Alexander Šulc, Petr Sanchez David, Raul Y. Vabret, Nicolas |
| Author_xml | – sequence: 1 givenname: Nicolas surname: Vabret fullname: Vabret, Nicolas email: nicolas.vabret@mssm.edu organization: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA – sequence: 2 givenname: Valérie surname: Najburg fullname: Najburg, Valérie organization: Viral Genomics and Vaccination Unit, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 3 givenname: Alexander surname: Solovyov fullname: Solovyov, Alexander organization: Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 4 givenname: Ramya surname: Gopal fullname: Gopal, Ramya organization: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA – sequence: 5 givenname: Christopher surname: McClain fullname: McClain, Christopher organization: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA – sequence: 6 givenname: Petr surname: Šulc fullname: Šulc, Petr organization: Center for Molecular Design and Biomimetics at the Biodesign Institute and School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA – sequence: 7 givenname: Sreekumar surname: Balan fullname: Balan, Sreekumar organization: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA – sequence: 8 givenname: Yannis surname: Rahou fullname: Rahou, Yannis organization: Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 9 givenname: Guillaume surname: Beauclair fullname: Beauclair, Guillaume organization: Viral Genomics and Vaccination Unit, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 10 givenname: Maxime surname: Chazal fullname: Chazal, Maxime organization: Viral Genomics and Vaccination Unit, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 11 givenname: Hugo surname: Varet fullname: Varet, Hugo organization: Transcriptome and EpiGenome Platform, BioMics, Center of Innovation and Technological Research, Institut Pasteur, Université de Paris, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France – sequence: 12 givenname: Rachel surname: Legendre fullname: Legendre, Rachel organization: Transcriptome and EpiGenome Platform, BioMics, Center of Innovation and Technological Research, Institut Pasteur, Université de Paris, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France – sequence: 13 givenname: Odile surname: Sismeiro fullname: Sismeiro, Odile organization: Transcriptome and EpiGenome Platform, BioMics, Center of Innovation and Technological Research, Institut Pasteur, Université de Paris, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France – sequence: 14 givenname: Raul Y. surname: Sanchez David fullname: Sanchez David, Raul Y. organization: Viral Genomics and Vaccination Unit, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 15 givenname: Lise surname: Chauveau fullname: Chauveau, Lise organization: Virus & Immunity Unit, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 16 givenname: Nolwenn surname: Jouvenet fullname: Jouvenet, Nolwenn organization: Viral Genomics and Vaccination Unit, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 17 givenname: Martin surname: Markowitz fullname: Markowitz, Martin organization: Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA – sequence: 18 givenname: Sylvie surname: van der Werf fullname: van der Werf, Sylvie organization: Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 19 givenname: Olivier surname: Schwartz fullname: Schwartz, Olivier organization: Virus & Immunity Unit, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 20 givenname: Frédéric surname: Tangy fullname: Tangy, Frédéric organization: Viral Genomics and Vaccination Unit, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France – sequence: 21 givenname: Nina surname: Bhardwaj fullname: Bhardwaj, Nina organization: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA – sequence: 22 givenname: Benjamin D. surname: Greenbaum fullname: Greenbaum, Benjamin D. organization: Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 23 givenname: Anastassia V. surname: Komarova fullname: Komarova, Anastassia V. email: anastasia.komarova@pasteur.fr organization: Viral Genomics and Vaccination Unit, Department of Virology, Institut Pasteur, Université de Paris, CNRS UMR-3569, 75015 Paris, France |
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| Cites_doi | 10.1038/s41590-017-0005-y 10.1073/pnas.1517584112 10.1038/nsmb.1806 10.1093/bioinformatics/btt656 10.1038/s41467-018-07314-7 10.1093/nar/gki504 10.1093/bioinformatics/bts635 10.1016/0042-6822(87)90458-2 10.1016/j.biocel.2015.07.003 10.1371/journal.ppat.1001284 10.1093/nar/gku1207 10.1126/sciimmunol.aau8943 10.1042/BST20160062 10.1371/journal.pone.0106418 10.1038/nsmb.1794 10.1038/nrg3001 10.1038/nn.3113 10.1093/nar/gkt214 10.1080/15476286.2017.1306169 10.1016/j.it.2016.10.006 10.1371/journal.ppat.1003678 10.1126/science.aac7442 10.1128/JVI.02654-08 10.14806/ej.17.1.200 10.18632/oncotarget.8420 10.1101/gr.101337.109 10.1016/j.celrep.2018.06.047 10.1146/annurev-pathol-011110-130254 10.1172/JCI91916 10.1126/science.1167525 10.1073/pnas.1216922110 10.1111/j.2517-6161.1995.tb02031.x 10.1146/annurev-immunol-042617-053309 10.7554/eLife.11275 10.1101/gad.340604.120 10.4161/cc.6.2.3732 10.1038/s41586-018-0768-9 10.1016/j.cell.2015.07.056 10.1006/jmbi.1999.2700 10.1016/j.jaut.2018.02.007 10.1128/JVI.77.21.11546-11554.2003 10.1186/s13059-014-0550-8 10.1128/JVI.01051-09 10.1093/molbev/msm084 10.1073/pnas.0911315106 10.1074/jbc.274.23.16590 10.1016/j.celrep.2018.03.042 10.1101/gad.282616.116 10.1016/j.cell.2015.10.020 10.1016/j.cell.2017.06.031 10.1016/j.celrep.2016.09.023 10.1093/nar/gkv1272 10.1038/nsmb.1801 10.1371/journal.ppat.1003328 10.1016/j.celrep.2016.05.059 10.1126/sciimmunol.aah5509 10.1097/QAI.0000000000000111 10.1128/MCB.20.17.6342-6353.2000 10.1128/jvi.64.6.3097-3099.1990 10.3389/fmicb.2014.00127 10.1016/j.cell.2021.08.004 10.1016/0092-8674(83)90059-4 |
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| References | Lucas-Hourani, Dauzonne, Jorda, Cousin, Lupan, Helynck, Caignard, Janvier, André-Leroux, Khiar (bib38) 2013; 9 Moqtaderi, Wang, Raha, White, Snyder, Weng, Struhl (bib44) 2010; 17 Liao, Smyth, Shi (bib35) 2013; 41 Vabret, Bhardwaj, Greenbaum (bib55) 2017; 38 Langevin, Maidou-Peindara, Aas, Jacquot, Otterlei, Slupphaug, Benichou (bib29) 2009; 83 Combredet, Labrousse, Mollet, Lorin, Delebecque, Hurtrel, McClure, Feinberg, Brahic, Tangy (bib14) 2003; 77 Ranoa, Parekh, Pitroda, Huang, Darga, Wong, Huang, Andrade, Staley, Satoh (bib49) 2016; 7 Johnson, Lee, Eacret, Ye, June, Minn (bib26) 2021; 184 Chow, Gale, Loo (bib11) 2018; 36 Markowitz, Evering, Garmon, Caskey, La Mar, Rodriguez, Sahi, Palmer, Prada, Mohri (bib40) 2014; 66 Love, Huber, Anders (bib37) 2014; 15 Tanne, Muniz, Puzio-Kuter, Leonova, Gudkov, Ting, Monasson, Cocco, Levine, Bhardwaj, Greenbaum (bib53) 2015; 112 Nabet, Qiu, Shabason, Wu, Yoon, Kim, Benci, DeMichele, Tchou, Marcotrigiano, Minn (bib45) 2017; 170 Dobin, Davis, Schlesinger, Drenkow, Zaleski, Jha, Batut, Chaisson, Gingeras (bib18) 2013; 29 Deshpande, Takagi, Hao, Buratowski, Charbonneau (bib17) 1999; 274 Covarrubias, Richner, Clyde, Lee, Glaunsinger (bib15) 2009; 83 Perreault, Noel, Briere, Cousineau, Lucier, Perreault, Boire (bib47) 2005; 33 Mackow, Makino, Zhao, Zhang, Markoff, Buckler-White, Guiler, Chanock, Lai (bib39) 1987; 159 Raha, Wang, Moqtaderi, Wu, Zhong, Gerstein, Struhl, Snyder (bib48) 2010; 107 Chiang, Sparrer, van Gent, Lässig, Huang, Osterrieder, Hopfner, Gack (bib8) 2018; 19 Oler, Alla, Roberts, Wong, Hollenhorst, Chandler, Cassiday, Nelson, Hagedorn, Graves, Cairns (bib46) 2010; 17 Mathews, Sabina, Zuker, Turner (bib42) 1999; 288 Choi, Burke, Szymanik, Nepal, Battenhouse, Lau, Stark, Lam, Sullivan (bib10) 2020; 34 Hubner, McNerney, Chen, Dale, Gordon, Chuang, Li, Asmuth, Huser, Chen (bib23) 2009; 323 Solovyov, Vabret, Arora, Snyder, Funt, Bajorin, Rosenberg, Bhardwaj, Ting, Greenbaum (bib52) 2018; 23 Le Rouzic, Belaïdouni, Estrabaud, Morel, Rain, Transy, Margottin-Goguet (bib31) 2007; 6 Lepelley, Louis, Sourisseau, Law, Pothlichet, Schilte, Chaperot, Plumas, Randall, Si-Tahar (bib34) 2011; 7 Burke, Sullivan (bib5) 2017; 14 Heidegger, Wintges, Stritzke, Bek, Steiger, Koenig, Göttert, Engleitner, Ollinger, Nedelko (bib21) 2019; 4 Law, Komarova, Yewdall, Lee, Herrera, Wodarz, Chen (bib30) 2016; 15 Cohen, Dehni, Sodroski, Haseltine (bib12) 1990; 64 Hung, Pratt, Sundararaman, Townsend, Chaivorapol, Bhangale, Graham, Ortmann, Criswell, Yeo, Behrens (bib24) 2015; 350 Benjamini, Hochberg (bib2) 1995; 57 Zhao, Ye, Dunker, Song, Karijolich (bib61) 2018; 9 Ishizuka, Manguso, Cheruiyot, Bi, Panda, Iracheta-Vellve, Miller, Du, Yates, Dubrot (bib25) 2019; 565 Roulois, Loo Yau, Singhania, Wang, Danesh, Shen, Han, Liang, Jones, Pugh (bib50) 2015; 162 Brister, Ako-Adjei, Bao, Blinkova (bib3) 2015; 43 Liao, Smyth, Shi (bib36) 2014; 30 Barski, Chepelev, Liko, Cuddapah, Fleming, Birch, Cui, White, Zhao (bib1) 2010; 17 Lehmann, Krüger, Park, Derkow, Rosenberger, Baumgart, Trimbuch, Eom, Hinz, Kaul (bib32) 2012; 15 Leonova, Brodsky, Lipchick, Pal, Novototskaya, Chenchik, Sen, Komarova, Gudkov (bib33) 2013; 110 Laforge, Limou, Harper, Casartelli, Rodrigues, Silvestre, Haloui, Zagury, Senik, Estaquier (bib28) 2013; 9 Wolin, Steitz (bib58) 1983; 32 Canella, Praz, Reina, Cousin, Hernandez (bib6) 2010; 20 Deeks, Odorizzi, Sekaly (bib16) 2016; 127 Vermeire, Roesch, Sauter, Rua, Hotter, Van Nuffel, Vanderstraeten, Naessens, Iannucci, Landi (bib56) 2016; 17 Chiappinelli, Strissel, Desrichard, Li, Henke, Akman, Hein, Rote, Cope, Snyder, Makarov, Budhu, Slamon, Wolchok, Pardoll, Beckmann, Zahnow, Merghoub, Chan, Baylin, Strick (bib9) 2016; 164 Guenzel, Hérate, Benichou (bib19) 2014; 5 Martin (bib41) 2011; 17 Perreault, Perreault, Boire (bib63) 2007; 24 Kowalski, Krude (bib27) 2015; 66 Hubley, Finn, Clements, Eddy, Jones, Bao, Smit, Wheeler (bib22) 2016; 44 Sanchez David, Combredet, Sismeiro, Dillies, Jagla, Coppée, Mura, Guerbois Galla, Despres, Tangy, Komarova (bib51) 2016; 5 White (bib57) 2011; 12 Burke, Kincaid, Nottingham, Lambowitz, Sullivan (bib4) 2016; 30 Lin, Génin, Mamane, Hiscott (bib62) 2000; 20 Chazal, Beauclair, Gracias, Najburg, Simon-Lorière, Tangy, Komarova, Jouvenet (bib7) 2018; 24 Turowski, Tollervey (bib54) 2016; 44 Zhao, Du, Peng, Li, Wang, Wang, Hou, Kang, Zheng, Hua, Yu (bib60) 2018; 90 Haderk, Schulz, Iskar, Cid, Worst, Willmund, Schulz, Warnken, Seiler, Benner (bib20) 2017; 2 Zahoor, Xue, Sato, Murakami, Takeshima, Aida (bib59) 2014; 9 Moir, Chun, Fauci (bib43) 2011; 6 Choi (10.1016/j.isci.2022.104599_bib10) 2020; 34 Mathews (10.1016/j.isci.2022.104599_bib42) 1999; 288 Ishizuka (10.1016/j.isci.2022.104599_bib25) 2019; 565 Burke (10.1016/j.isci.2022.104599_bib5) 2017; 14 Langevin (10.1016/j.isci.2022.104599_bib29) 2009; 83 Lin (10.1016/j.isci.2022.104599_bib62) 2000; 20 Oler (10.1016/j.isci.2022.104599_bib46) 2010; 17 Perreault (10.1016/j.isci.2022.104599_bib47) 2005; 33 Canella (10.1016/j.isci.2022.104599_bib6) 2010; 20 Lucas-Hourani (10.1016/j.isci.2022.104599_bib38) 2013; 9 Raha (10.1016/j.isci.2022.104599_bib48) 2010; 107 Burke (10.1016/j.isci.2022.104599_bib4) 2016; 30 Hubley (10.1016/j.isci.2022.104599_bib22) 2016; 44 Hung (10.1016/j.isci.2022.104599_bib24) 2015; 350 Laforge (10.1016/j.isci.2022.104599_bib28) 2013; 9 White (10.1016/j.isci.2022.104599_bib57) 2011; 12 Leonova (10.1016/j.isci.2022.104599_bib33) 2013; 110 Kowalski (10.1016/j.isci.2022.104599_bib27) 2015; 66 Vermeire (10.1016/j.isci.2022.104599_bib56) 2016; 17 Guenzel (10.1016/j.isci.2022.104599_bib19) 2014; 5 Chiappinelli (10.1016/j.isci.2022.104599_bib9) 2016; 164 Combredet (10.1016/j.isci.2022.104599_bib14) 2003; 77 Benjamini (10.1016/j.isci.2022.104599_bib2) 1995; 57 Chazal (10.1016/j.isci.2022.104599_bib7) 2018; 24 Zahoor (10.1016/j.isci.2022.104599_bib59) 2014; 9 Deeks (10.1016/j.isci.2022.104599_bib16) 2016; 127 Chiang (10.1016/j.isci.2022.104599_bib8) 2018; 19 Deshpande (10.1016/j.isci.2022.104599_bib17) 1999; 274 Love (10.1016/j.isci.2022.104599_bib37) 2014; 15 Martin (10.1016/j.isci.2022.104599_bib41) 2011; 17 Vabret (10.1016/j.isci.2022.104599_bib55) 2017; 38 Lehmann (10.1016/j.isci.2022.104599_bib32) 2012; 15 Johnson (10.1016/j.isci.2022.104599_bib26) 2021; 184 Markowitz (10.1016/j.isci.2022.104599_bib40) 2014; 66 Roulois (10.1016/j.isci.2022.104599_bib50) 2015; 162 Moir (10.1016/j.isci.2022.104599_bib43) 2011; 6 Liao (10.1016/j.isci.2022.104599_bib35) 2013; 41 Barski (10.1016/j.isci.2022.104599_bib1) 2010; 17 Ranoa (10.1016/j.isci.2022.104599_bib49) 2016; 7 Perreault (10.1016/j.isci.2022.104599_bib63) 2007; 24 Zhao (10.1016/j.isci.2022.104599_bib60) 2018; 90 Sanchez David (10.1016/j.isci.2022.104599_bib51) 2016; 5 Heidegger (10.1016/j.isci.2022.104599_bib21) 2019; 4 Moqtaderi (10.1016/j.isci.2022.104599_bib44) 2010; 17 Cohen (10.1016/j.isci.2022.104599_bib12) 1990; 64 Solovyov (10.1016/j.isci.2022.104599_bib52) 2018; 23 Wolin (10.1016/j.isci.2022.104599_bib58) 1983; 32 Haderk (10.1016/j.isci.2022.104599_bib20) 2017; 2 Hubner (10.1016/j.isci.2022.104599_bib23) 2009; 323 Turowski (10.1016/j.isci.2022.104599_bib54) 2016; 44 Brister (10.1016/j.isci.2022.104599_bib3) 2015; 43 Tanne (10.1016/j.isci.2022.104599_bib53) 2015; 112 Covarrubias (10.1016/j.isci.2022.104599_bib15) 2009; 83 Law (10.1016/j.isci.2022.104599_bib30) 2016; 15 Lepelley (10.1016/j.isci.2022.104599_bib34) 2011; 7 Le Rouzic (10.1016/j.isci.2022.104599_bib31) 2007; 6 Zhao (10.1016/j.isci.2022.104599_bib61) 2018; 9 Liao (10.1016/j.isci.2022.104599_bib36) 2014; 30 Nabet (10.1016/j.isci.2022.104599_bib45) 2017; 170 Dobin (10.1016/j.isci.2022.104599_bib18) 2013; 29 Mackow (10.1016/j.isci.2022.104599_bib39) 1987; 159 Chow (10.1016/j.isci.2022.104599_bib11) 2018; 36 |
| References_xml | – volume: 9 start-page: e1003678 year: 2013 ident: bib38 article-title: Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity publication-title: PLoS Pathog. – volume: 44 start-page: 1367 year: 2016 end-page: 1375 ident: bib54 article-title: Transcription by RNA polymerase III: insights into mechanism and regulation publication-title: Biochem. Soc. Trans. – volume: 77 start-page: 11546 year: 2003 end-page: 11554 ident: bib14 article-title: A molecularly cloned Schwarz strain of measles virus vaccine induces strong immune responses in macaques and transgenic mice publication-title: J. Virol. – volume: 162 start-page: 961 year: 2015 end-page: 973 ident: bib50 article-title: DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts publication-title: Cell – volume: 33 start-page: 2032 year: 2005 end-page: 2041 ident: bib47 article-title: Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs publication-title: Nucleic Acids Res. – volume: 5 start-page: 127 year: 2014 ident: bib19 article-title: HIV-1 Vpr-a still "enigmatic multitasker" publication-title: Front. Microbiol. – volume: 184 start-page: 4981 year: 2021 end-page: 4995.e14 ident: bib26 article-title: The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function publication-title: Cell – volume: 350 start-page: 455 year: 2015 end-page: 459 ident: bib24 article-title: The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression publication-title: Science – volume: 2 start-page: eaah5509 year: 2017 ident: bib20 article-title: Tumor-derived exosomes modulate PD-L1 expression in monocytes publication-title: Sci Immunol. – volume: 7 start-page: e1001284 year: 2011 ident: bib34 article-title: Innate sensing of HIV-infected cells publication-title: PLoS Pathog. – volume: 20 start-page: 710 year: 2010 end-page: 721 ident: bib6 article-title: Defining the RNA polymerase III transcriptome: genome-wide localization of the RNA polymerase III transcription machinery in human cells publication-title: Genome Res. – volume: 7 start-page: 26496 year: 2016 end-page: 26515 ident: bib49 article-title: Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs publication-title: Oncotarget. – volume: 83 start-page: 10256 year: 2009 end-page: 10263 ident: bib29 article-title: Human immunodeficiency virus type 1 Vpr modulates cellular expression of UNG2 via a negative transcriptional effect publication-title: J. Virol. – volume: 66 start-page: 20 year: 2015 end-page: 29 ident: bib27 article-title: Functional roles of non-coding Y RNAs publication-title: Int. J. Biochem. Cell Biol. – volume: 43 start-page: D571 year: 2015 end-page: D577 ident: bib3 article-title: NCBI viral genomes resource publication-title: Nucleic Acids Res. – volume: 6 start-page: 182 year: 2007 end-page: 188 ident: bib31 article-title: HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase publication-title: Cell Cycle – volume: 14 start-page: 1457 year: 2017 end-page: 1465 ident: bib5 article-title: DUSP11 - an RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells publication-title: RNA Biol. – volume: 66 start-page: 140 year: 2014 end-page: 147 ident: bib40 article-title: A randomized open-label study of 3- versus 5-drug combination antiretroviral therapy in newly HIV-1-infected individuals publication-title: J. Acquir. Immune Defic. Syndr. – volume: 17 start-page: 10 year: 2011 end-page: 12 ident: bib41 article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads publication-title: EMBnet.journal – volume: 90 start-page: 105 year: 2018 end-page: 115 ident: bib60 article-title: LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways publication-title: J. Autoimmun. – volume: 127 start-page: 103 year: 2016 end-page: 105 ident: bib16 article-title: The interferon paradox: can inhibiting an antiviral mechanism advance an HIV cure? publication-title: J. Clin. Invest. – volume: 9 start-page: e1003328 year: 2013 ident: bib28 article-title: DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV publication-title: PLoS Pathog. – volume: 38 start-page: 53 year: 2017 end-page: 65 ident: bib55 article-title: Sequence-specific sensing of nucleic acids publication-title: Trends Immunol. – volume: 15 start-page: 2771 year: 2016 end-page: 2783 ident: bib30 article-title: In vivo HIV-1 cell-to-cell transmission promotes multicopy micro-compartmentalized infection publication-title: Cell Rep. – volume: 112 start-page: 15154 year: 2015 end-page: 15159 ident: bib53 article-title: Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells publication-title: Proc. Natl. Acad. Sci. USA – volume: 15 start-page: 827 year: 2012 end-page: 835 ident: bib32 article-title: An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration publication-title: Nat. Neurosci. – volume: 24 start-page: 320 year: 2018 end-page: 328 ident: bib7 article-title: RIG-I recognizes the 5' region of dengue and zika virus genomes publication-title: Cell Rep. – volume: 164 start-page: 1073 year: 2016 ident: bib9 article-title: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses publication-title: Cell – volume: 6 start-page: 223 year: 2011 end-page: 248 ident: bib43 article-title: Pathogenic mechanisms of HIV disease publication-title: Annu. Rev. Pathol. – volume: 64 start-page: 3097 year: 1990 end-page: 3099 ident: bib12 article-title: Human immunodeficiency virus vpr product is a virion-associated regulatory protein publication-title: J. Virol. – volume: 30 start-page: 923 year: 2014 end-page: 930 ident: bib36 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib2 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. Roy. Stat. Soc. B – volume: 9 start-page: 4841 year: 2018 ident: bib61 article-title: RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection publication-title: Nat. Commun. – volume: 36 start-page: 667 year: 2018 end-page: 694 ident: bib11 article-title: RIG-I and other RNA sensors in antiviral immunity publication-title: Annu. Rev. Immunol. – volume: 12 start-page: 459 year: 2011 end-page: 463 ident: bib57 article-title: Transcription by RNA polymerase III: more complex than we thought publication-title: Nat. Rev. Genet. – volume: 274 start-page: 16590 year: 1999 end-page: 16594 ident: bib17 article-title: Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activities publication-title: J. Biol. Chem. – volume: 83 start-page: 9554 year: 2009 end-page: 9566 ident: bib15 article-title: Host shutoff is a conserved phenotype of gammaherpesvirus infection and is orchestrated exclusively from the cytoplasm publication-title: J. Virol. – volume: 170 start-page: 352 year: 2017 end-page: 366.e13 ident: bib45 article-title: Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer publication-title: Cell – volume: 110 start-page: E89 year: 2013 end-page: E98 ident: bib33 article-title: p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs publication-title: Proc. Natl. Acad. Sci. USA – volume: 15 start-page: 550 year: 2014 ident: bib37 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: bib18 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics – volume: 24 start-page: 1678 year: 2007 end-page: 1689 ident: bib63 article-title: Ro-associated Y RNAs in metazoans: evolution and diversification publication-title: Mol. Biol. Evol. – volume: 323 start-page: 1743 year: 2009 end-page: 1747 ident: bib23 article-title: Quantitative 3D video microscopy of HIV transfer across T cell virological synapses publication-title: Science – volume: 17 start-page: 635 year: 2010 end-page: 640 ident: bib44 article-title: Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells publication-title: Nat. Struct. Mol. Biol. – volume: 17 start-page: 620 year: 2010 end-page: 628 ident: bib46 article-title: Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors publication-title: Nat. Struct. Mol. Biol. – volume: 17 start-page: 413 year: 2016 end-page: 424 ident: bib56 article-title: HIV triggers a cGAS-dependent, vpu- and vpr-regulated type I interferon response in CD4(+) T cells publication-title: Cell Rep. – volume: 30 start-page: 2076 year: 2016 end-page: 2092 ident: bib4 article-title: DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs publication-title: Genes Dev. – volume: 5 start-page: e11275 year: 2016 ident: bib51 article-title: Comparative analysis of viral RNA signatures on different RIG-I-like receptors publication-title: Elife – volume: 17 start-page: 629 year: 2010 end-page: 634 ident: bib1 article-title: Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes publication-title: Nat. Struct. Mol. Biol. – volume: 159 start-page: 217 year: 1987 end-page: 228 ident: bib39 article-title: The nucleotide sequence of dengue type 4 virus: analysis of genes coding for nonstructural proteins publication-title: Virology – volume: 19 start-page: 53 year: 2018 end-page: 62 ident: bib8 article-title: Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity publication-title: Nat. Immunol. – volume: 565 start-page: 43 year: 2019 end-page: 48 ident: bib25 article-title: Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade publication-title: Nature – volume: 4 start-page: eaau8943 year: 2019 ident: bib21 article-title: RIG-I activation is critical for responsiveness to checkpoint blockade publication-title: Sci Immunol. – volume: 34 start-page: 1697 year: 2020 end-page: 1712 ident: bib10 article-title: DUSP11-mediated control of 5'-triphosphate RNA regulates RIG-I sensitivity publication-title: Genes Dev. – volume: 20 start-page: 6342 year: 2000 end-page: 6353 ident: bib62 article-title: Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7 publication-title: Mol. Cell. Biol. – volume: 41 start-page: e108 year: 2013 ident: bib35 article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote publication-title: Nucleic Acids Res. – volume: 288 start-page: 911 year: 1999 end-page: 940 ident: bib42 article-title: Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure publication-title: J. Mol. Biol. – volume: 44 start-page: D81 year: 2016 end-page: D89 ident: bib22 article-title: The Dfam database of repetitive DNA families publication-title: Nucleic Acids Res. – volume: 107 start-page: 3639 year: 2010 end-page: 3644 ident: bib48 article-title: Close association of RNA polymerase II and many transcription factors with Pol III genes publication-title: Proc. Natl. Acad. Sci. USA – volume: 32 start-page: 735 year: 1983 end-page: 744 ident: bib58 article-title: Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome publication-title: Cell – volume: 23 start-page: 512 year: 2018 end-page: 521 ident: bib52 article-title: Global cancer transcriptome quantifies repeat element polarization between immunotherapy responsive and T cell suppressive classes publication-title: Cell Rep. – volume: 9 start-page: e106418 year: 2014 ident: bib59 article-title: HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages publication-title: PLoS One – volume: 19 start-page: 53 year: 2018 ident: 10.1016/j.isci.2022.104599_bib8 article-title: Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity publication-title: Nat. Immunol. doi: 10.1038/s41590-017-0005-y – volume: 112 start-page: 15154 year: 2015 ident: 10.1016/j.isci.2022.104599_bib53 article-title: Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1517584112 – volume: 17 start-page: 629 year: 2010 ident: 10.1016/j.isci.2022.104599_bib1 article-title: Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.1806 – volume: 30 start-page: 923 year: 2014 ident: 10.1016/j.isci.2022.104599_bib36 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt656 – volume: 9 start-page: 4841 year: 2018 ident: 10.1016/j.isci.2022.104599_bib61 article-title: RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection publication-title: Nat. Commun. doi: 10.1038/s41467-018-07314-7 – volume: 33 start-page: 2032 year: 2005 ident: 10.1016/j.isci.2022.104599_bib47 article-title: Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs publication-title: Nucleic Acids Res. doi: 10.1093/nar/gki504 – volume: 29 start-page: 15 year: 2013 ident: 10.1016/j.isci.2022.104599_bib18 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 159 start-page: 217 year: 1987 ident: 10.1016/j.isci.2022.104599_bib39 article-title: The nucleotide sequence of dengue type 4 virus: analysis of genes coding for nonstructural proteins publication-title: Virology doi: 10.1016/0042-6822(87)90458-2 – volume: 66 start-page: 20 year: 2015 ident: 10.1016/j.isci.2022.104599_bib27 article-title: Functional roles of non-coding Y RNAs publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2015.07.003 – volume: 7 start-page: e1001284 year: 2011 ident: 10.1016/j.isci.2022.104599_bib34 article-title: Innate sensing of HIV-infected cells publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1001284 – volume: 43 start-page: D571 year: 2015 ident: 10.1016/j.isci.2022.104599_bib3 article-title: NCBI viral genomes resource publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1207 – volume: 4 start-page: eaau8943 year: 2019 ident: 10.1016/j.isci.2022.104599_bib21 article-title: RIG-I activation is critical for responsiveness to checkpoint blockade publication-title: Sci Immunol. doi: 10.1126/sciimmunol.aau8943 – volume: 44 start-page: 1367 year: 2016 ident: 10.1016/j.isci.2022.104599_bib54 article-title: Transcription by RNA polymerase III: insights into mechanism and regulation publication-title: Biochem. Soc. Trans. doi: 10.1042/BST20160062 – volume: 9 start-page: e106418 year: 2014 ident: 10.1016/j.isci.2022.104599_bib59 article-title: HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages publication-title: PLoS One doi: 10.1371/journal.pone.0106418 – volume: 17 start-page: 635 year: 2010 ident: 10.1016/j.isci.2022.104599_bib44 article-title: Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.1794 – volume: 12 start-page: 459 year: 2011 ident: 10.1016/j.isci.2022.104599_bib57 article-title: Transcription by RNA polymerase III: more complex than we thought publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3001 – volume: 15 start-page: 827 year: 2012 ident: 10.1016/j.isci.2022.104599_bib32 article-title: An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration publication-title: Nat. Neurosci. doi: 10.1038/nn.3113 – volume: 41 start-page: e108 year: 2013 ident: 10.1016/j.isci.2022.104599_bib35 article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt214 – volume: 14 start-page: 1457 year: 2017 ident: 10.1016/j.isci.2022.104599_bib5 article-title: DUSP11 - an RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells publication-title: RNA Biol. doi: 10.1080/15476286.2017.1306169 – volume: 38 start-page: 53 year: 2017 ident: 10.1016/j.isci.2022.104599_bib55 article-title: Sequence-specific sensing of nucleic acids publication-title: Trends Immunol. doi: 10.1016/j.it.2016.10.006 – volume: 9 start-page: e1003678 year: 2013 ident: 10.1016/j.isci.2022.104599_bib38 article-title: Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1003678 – volume: 350 start-page: 455 year: 2015 ident: 10.1016/j.isci.2022.104599_bib24 article-title: The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression publication-title: Science doi: 10.1126/science.aac7442 – volume: 83 start-page: 10256 year: 2009 ident: 10.1016/j.isci.2022.104599_bib29 article-title: Human immunodeficiency virus type 1 Vpr modulates cellular expression of UNG2 via a negative transcriptional effect publication-title: J. Virol. doi: 10.1128/JVI.02654-08 – volume: 17 start-page: 10 year: 2011 ident: 10.1016/j.isci.2022.104599_bib41 article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads publication-title: EMBnet.journal doi: 10.14806/ej.17.1.200 – volume: 7 start-page: 26496 year: 2016 ident: 10.1016/j.isci.2022.104599_bib49 article-title: Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs publication-title: Oncotarget. doi: 10.18632/oncotarget.8420 – volume: 20 start-page: 710 year: 2010 ident: 10.1016/j.isci.2022.104599_bib6 article-title: Defining the RNA polymerase III transcriptome: genome-wide localization of the RNA polymerase III transcription machinery in human cells publication-title: Genome Res. doi: 10.1101/gr.101337.109 – volume: 24 start-page: 320 year: 2018 ident: 10.1016/j.isci.2022.104599_bib7 article-title: RIG-I recognizes the 5' region of dengue and zika virus genomes publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.06.047 – volume: 6 start-page: 223 year: 2011 ident: 10.1016/j.isci.2022.104599_bib43 article-title: Pathogenic mechanisms of HIV disease publication-title: Annu. Rev. Pathol. doi: 10.1146/annurev-pathol-011110-130254 – volume: 127 start-page: 103 year: 2016 ident: 10.1016/j.isci.2022.104599_bib16 article-title: The interferon paradox: can inhibiting an antiviral mechanism advance an HIV cure? publication-title: J. Clin. Invest. doi: 10.1172/JCI91916 – volume: 323 start-page: 1743 year: 2009 ident: 10.1016/j.isci.2022.104599_bib23 article-title: Quantitative 3D video microscopy of HIV transfer across T cell virological synapses publication-title: Science doi: 10.1126/science.1167525 – volume: 110 start-page: E89 year: 2013 ident: 10.1016/j.isci.2022.104599_bib33 article-title: p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1216922110 – volume: 57 start-page: 289 year: 1995 ident: 10.1016/j.isci.2022.104599_bib2 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. Roy. Stat. Soc. B doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 36 start-page: 667 year: 2018 ident: 10.1016/j.isci.2022.104599_bib11 article-title: RIG-I and other RNA sensors in antiviral immunity publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-042617-053309 – volume: 5 start-page: e11275 year: 2016 ident: 10.1016/j.isci.2022.104599_bib51 article-title: Comparative analysis of viral RNA signatures on different RIG-I-like receptors publication-title: Elife doi: 10.7554/eLife.11275 – volume: 34 start-page: 1697 year: 2020 ident: 10.1016/j.isci.2022.104599_bib10 article-title: DUSP11-mediated control of 5'-triphosphate RNA regulates RIG-I sensitivity publication-title: Genes Dev. doi: 10.1101/gad.340604.120 – volume: 6 start-page: 182 year: 2007 ident: 10.1016/j.isci.2022.104599_bib31 article-title: HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase publication-title: Cell Cycle doi: 10.4161/cc.6.2.3732 – volume: 565 start-page: 43 year: 2019 ident: 10.1016/j.isci.2022.104599_bib25 article-title: Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade publication-title: Nature doi: 10.1038/s41586-018-0768-9 – volume: 162 start-page: 961 year: 2015 ident: 10.1016/j.isci.2022.104599_bib50 article-title: DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts publication-title: Cell doi: 10.1016/j.cell.2015.07.056 – volume: 288 start-page: 911 year: 1999 ident: 10.1016/j.isci.2022.104599_bib42 article-title: Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure publication-title: J. Mol. Biol. doi: 10.1006/jmbi.1999.2700 – volume: 90 start-page: 105 year: 2018 ident: 10.1016/j.isci.2022.104599_bib60 article-title: LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways publication-title: J. Autoimmun. doi: 10.1016/j.jaut.2018.02.007 – volume: 77 start-page: 11546 year: 2003 ident: 10.1016/j.isci.2022.104599_bib14 article-title: A molecularly cloned Schwarz strain of measles virus vaccine induces strong immune responses in macaques and transgenic mice publication-title: J. Virol. doi: 10.1128/JVI.77.21.11546-11554.2003 – volume: 15 start-page: 550 year: 2014 ident: 10.1016/j.isci.2022.104599_bib37 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 83 start-page: 9554 year: 2009 ident: 10.1016/j.isci.2022.104599_bib15 article-title: Host shutoff is a conserved phenotype of gammaherpesvirus infection and is orchestrated exclusively from the cytoplasm publication-title: J. Virol. doi: 10.1128/JVI.01051-09 – volume: 24 start-page: 1678 year: 2007 ident: 10.1016/j.isci.2022.104599_bib63 article-title: Ro-associated Y RNAs in metazoans: evolution and diversification publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msm084 – volume: 107 start-page: 3639 year: 2010 ident: 10.1016/j.isci.2022.104599_bib48 article-title: Close association of RNA polymerase II and many transcription factors with Pol III genes publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0911315106 – volume: 274 start-page: 16590 year: 1999 ident: 10.1016/j.isci.2022.104599_bib17 article-title: Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activities publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.23.16590 – volume: 23 start-page: 512 year: 2018 ident: 10.1016/j.isci.2022.104599_bib52 article-title: Global cancer transcriptome quantifies repeat element polarization between immunotherapy responsive and T cell suppressive classes publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.03.042 – volume: 30 start-page: 2076 year: 2016 ident: 10.1016/j.isci.2022.104599_bib4 article-title: DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs publication-title: Genes Dev. doi: 10.1101/gad.282616.116 – volume: 164 start-page: 1073 year: 2016 ident: 10.1016/j.isci.2022.104599_bib9 article-title: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses publication-title: Cell doi: 10.1016/j.cell.2015.10.020 – volume: 170 start-page: 352 year: 2017 ident: 10.1016/j.isci.2022.104599_bib45 article-title: Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer publication-title: Cell doi: 10.1016/j.cell.2017.06.031 – volume: 17 start-page: 413 year: 2016 ident: 10.1016/j.isci.2022.104599_bib56 article-title: HIV triggers a cGAS-dependent, vpu- and vpr-regulated type I interferon response in CD4(+) T cells publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.09.023 – volume: 44 start-page: D81 year: 2016 ident: 10.1016/j.isci.2022.104599_bib22 article-title: The Dfam database of repetitive DNA families publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv1272 – volume: 17 start-page: 620 year: 2010 ident: 10.1016/j.isci.2022.104599_bib46 article-title: Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.1801 – volume: 9 start-page: e1003328 year: 2013 ident: 10.1016/j.isci.2022.104599_bib28 article-title: DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1003328 – volume: 15 start-page: 2771 year: 2016 ident: 10.1016/j.isci.2022.104599_bib30 article-title: In vivo HIV-1 cell-to-cell transmission promotes multicopy micro-compartmentalized infection publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.05.059 – volume: 2 start-page: eaah5509 year: 2017 ident: 10.1016/j.isci.2022.104599_bib20 article-title: Tumor-derived exosomes modulate PD-L1 expression in monocytes publication-title: Sci Immunol. doi: 10.1126/sciimmunol.aah5509 – volume: 66 start-page: 140 year: 2014 ident: 10.1016/j.isci.2022.104599_bib40 article-title: A randomized open-label study of 3- versus 5-drug combination antiretroviral therapy in newly HIV-1-infected individuals publication-title: J. Acquir. Immune Defic. Syndr. doi: 10.1097/QAI.0000000000000111 – volume: 20 start-page: 6342 year: 2000 ident: 10.1016/j.isci.2022.104599_bib62 article-title: Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.20.17.6342-6353.2000 – volume: 64 start-page: 3097 year: 1990 ident: 10.1016/j.isci.2022.104599_bib12 article-title: Human immunodeficiency virus vpr product is a virion-associated regulatory protein publication-title: J. Virol. doi: 10.1128/jvi.64.6.3097-3099.1990 – volume: 5 start-page: 127 year: 2014 ident: 10.1016/j.isci.2022.104599_bib19 article-title: HIV-1 Vpr-a still "enigmatic multitasker" publication-title: Front. Microbiol. doi: 10.3389/fmicb.2014.00127 – volume: 184 start-page: 4981 year: 2021 ident: 10.1016/j.isci.2022.104599_bib26 article-title: The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function publication-title: Cell doi: 10.1016/j.cell.2021.08.004 – volume: 32 start-page: 735 year: 1983 ident: 10.1016/j.isci.2022.104599_bib58 article-title: Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome publication-title: Cell doi: 10.1016/0092-8674(83)90059-4 |
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