The effect of mouthrinses containing zinc and triclosan on plaque accumulation, development of gingivitis and formation of calculus in a 28-week clinical test

Experimental mouthrinses containing 0.4% zinc sulphate and 0.15% triclosan, which differed in base formulations were compared to a commercially available non-active control mouthrinse. Following baseline clinical examinations for plaque, gingival bleeding and calculus, the volunteers were provided w...

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Bibliographic Details
Published in:Journal of clinical periodontology Vol. 23; no. 5; p. 465
Main Authors: Schaeken, M J, Van der Hoeven, J S, Saxton, C A, Cummins, D
Format: Journal Article
Language:English
Published: United States 01.05.1996
Subjects:
Analysis of Variance
Anti-Infective Agents, Local - administration & dosage
Anti-Infective Agents, Local - adverse effects
Anti-Infective Agents, Local - therapeutic use
Colony Count, Microbial
Dental Calculus - etiology
Dental Calculus - prevention & control
Dental Plaque - etiology
Dental Plaque - prevention & control
Dental Prophylaxis
Follow-Up Studies
Gingival Hemorrhage - etiology
Gingival Hemorrhage - prevention & control
Gingivitis - etiology
Gingivitis - prevention & control
Health Education, Dental
Humans
Irritants - adverse effects
Mouthwashes - adverse effects
Mouthwashes - therapeutic use
Oral Hygiene
Saliva - microbiology
Streptococcus mutans - drug effects
Streptococcus mutans - isolation & purification
Taste - drug effects
Triclosan - administration & dosage
Triclosan - adverse effects
Triclosan - therapeutic use
Zinc Sulfate - administration & dosage
Zinc Sulfate - adverse effects
Zinc Sulfate - therapeutic use
ISSN:0303-6979
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Summary:Experimental mouthrinses containing 0.4% zinc sulphate and 0.15% triclosan, which differed in base formulations were compared to a commercially available non-active control mouthrinse. Following baseline clinical examinations for plaque, gingival bleeding and calculus, the volunteers were provided with a dental prophylaxis and given oral hygiene instruction, stratified into 3 groups and given 1 of 3 mouthrinses. Further clinical assessments were performed after 4, 16 and 28 weeks. Salivary mutans streptococci were also monitored during the study. At 4 weeks, plaque and calculus scores in all groups were low compared to baseline. During the remainder of the study, these improvements were not maintained and both plaque and calculus levels increased in all groups. Plaque was significantly lower (P < 0.05) than in the control at all time points. Calculus was significantly lower (P < 0.05) than in the control at all time points. Calculus was significantly lower at week 28 for experimental mouthrinse group 2. Gingival bleeding also decreased in the initial 4 weeks but increased thereafter in the control group. In contrast, gingival bleeding was significantly (P < 0.05) lower in the two experimental groups than in the control group. No significant changes in mutans streptococci were observed.
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ISSN:0303-6979
DOI:10.1111/j.1600-051X.1996.tb00576.x