The effects of a dentifrice containing a zinc salt and a non-cationic antimicrobial agent on plaque and gingivitis

The antiplaque potential of metal salts in mouthwashes or dentifrices has been previously demonstrated. The purpose of the present investigation was to establish the effects on plaque and gingival health of a dentifrice which contained a combination of the metal salt, zinc citrate, and the anti-micr...

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Bibliographic Details
Published in:Journal of clinical periodontology Vol. 14; no. 3; p. 144
Main Authors: Saxton, C A, Lane, R M, van der Ouderaa, F
Format: Journal Article
Language:English
Published: United States 01.03.1987
Subjects:
Adolescent
Adult
Citrates - administration & dosage
Citrates - pharmacology
Citrates - therapeutic use
Citric Acid
Dental Plaque - prevention & control
Dentifrices - therapeutic use
Double-Blind Method
Drug Combinations
Female
Gingivitis - prevention & control
Humans
Male
Middle Aged
Phenyl Ethers - therapeutic use
Pilot Projects
Placebos
Toothbrushing
Triclosan - administration & dosage
Triclosan - pharmacology
Triclosan - therapeutic use
ISSN:0303-6979
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Summary:The antiplaque potential of metal salts in mouthwashes or dentifrices has been previously demonstrated. The purpose of the present investigation was to establish the effects on plaque and gingival health of a dentifrice which contained a combination of the metal salt, zinc citrate, and the anti-microbial agent, Triclosan. Plaque growth was reduced by a dentifrice which contained either zinc citrate or triclosan, but greater inhibition was achieved with dentifrices which contained both agents. A 4-day non-brushing study in which slurries of the dentifrice were used, confirmed that the test dentifrice which contained 1% zinc citrate and 0.5% Triclosan reduced the accumulation of plaque by 50%. In a double-blind crossover study of 28 days duration, a significant reduction in plaque accumulation and an improvement in gingival health was demonstrated for the test dentifrice compared to the placebo. Further analysis of the data indicated that the dentifrice was most efficacious for participants who brushed ineffectively. Also, the greatest benefit was obtained by subjects that used the largest amount of dentifrice.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0303-6979
DOI:10.1111/j.1600-051X.1987.tb00957.x