Antigen Presentation in the CNS by Myeloid Dendritic Cells Drives Progression of Relapsing Experimental Autoimmune Encephalomyelitis

: Chronic progression of relapsing experimental autoimmune encephalomyelitis (R‐EAE), a mouse model of multiple sclerosis (MS), is dependent on the activation of T cells to endogenous myelin epitopes, that is, epitope spreading. This review focuses on the cellular and molecular mechanisms underlyin...

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Bibliographic Details
Published in:	Annals of the New York Academy of Sciences Vol. 1103; no. 1; pp. 179 - 191
Main Authors:	MILLER, STEPHEN D., McMAHON, EILEEN J., SCHREINER, BETTINA, BAILEY, SAMANTHA L.
Format:	Journal Article
Language:	English
Published:	Malden, USA Blackwell Publishing Inc 01.04.2007
Subjects:	Animals antigen presentation central nervous system Central Nervous System - immunology Chronic Disease dendritic cells Dendritic Cells - immunology Disease Models, Animal Disease Progression Encephalomyelitis, Autoimmune, Experimental - immunology epitope spreading Epitopes - immunology experimental autoimmune encephalomyelitis Mice Mice, Inbred Strains Models, Immunological multiple sclerosis Multiple Sclerosis - immunology Recurrence
ISSN:	0077-8923, 1749-6632, 1930-6547
Online Access:	Get full text
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