Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz [version 1; peer review: 3 approved]

The precision medicine paradigm is centered on therapies targeted to particular molecular entities that will elicit an anticipated and controlled therapeutic response. However, genetic alterations in the drug targets themselves or in genes whose products interact with the targets can affect how well...

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Vydané v:	F1000 research Ročník 8; s. 908
Hlavní autori:	Blucher, Aurora S, McWeeney, Shannon K, Stein, Lincoln, Wu, Guanming
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Faculty of 1000 Ltd 2019 F1000 Research Limited F1000 Research Ltd
Predmet:	Cancer therapies Drug resistance Fuzzy logic Genes Genomes Metabolism Mutation Ordinary differential equations Ovarian cancer Patients Precision medicine Signal transduction Software Tool Variables Visualization Oregon Canada United States > US targeted therapy functional interaction network drug interaction visualization biological pathway systems pharmacology Boolean network constrained fuzzy logic modeling Reactome
ISSN:	2046-1402, 2046-1402
On-line prístup:	Získať plný text
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