Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz [version 1; peer review: 3 approved]

The precision medicine paradigm is centered on therapies targeted to particular molecular entities that will elicit an anticipated and controlled therapeutic response. However, genetic alterations in the drug targets themselves or in genes whose products interact with the targets can affect how well...

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Veröffentlicht in:	F1000 research Jg. 8; S. 908
Hauptverfasser:	Blucher, Aurora S, McWeeney, Shannon K, Stein, Lincoln, Wu, Guanming
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Faculty of 1000 Ltd 2019 F1000 Research Limited F1000 Research Ltd
Schlagworte:	Cancer therapies Drug resistance Fuzzy logic Genes Genomes Metabolism Mutation Ordinary differential equations Ovarian cancer Patients Precision medicine Signal transduction Software Tool Variables Visualization Oregon Canada United States > US targeted therapy functional interaction network drug interaction visualization biological pathway systems pharmacology Boolean network constrained fuzzy logic modeling Reactome
ISSN:	2046-1402, 2046-1402
Online-Zugang:	Volltext
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