Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation

Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting p...

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Veröffentlicht in:FEBS letters Jg. 598; H. 22; S. 2807 - 2808
Hauptverfasser: Citterio, Elisabetta, Ronchi, Antonella Ellena
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England John Wiley and Sons Inc 01.11.2024
Schlagworte:
Acute Myeloid Leukemia (AML)
Aging
Aging - metabolism
Aging - pathology
Animals
blood
Cellular Senescence
Deubiquitinases
Deubiquitinating enzymes (DUBs)
Deubiquitinating Enzymes - genetics
Deubiquitinating Enzymes - metabolism
elderly
Graphical Review
hematopoietic stem cells
Hematopoietic Stem Cells (HSC)
Hematopoietic Stem Cells - enzymology
Hematopoietic Stem Cells - metabolism
Hematopoietic Stem Cells - pathology
Humans
Myelodysplastic Syndromes (MDS)
Myelodysplastic Syndromes - enzymology
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - metabolism
Myelodysplastic Syndromes - pathology
Ubiquitination
ubiquitinyl hydrolase 1
Hematopoietic Stem Cells (HSC)
Ubiquitination
Deubiquitinating enzymes (DUBs)
Myelodysplastic Syndromes (MDS)
Aging
Deubiquitinases
Acute Myeloid Leukemia (AML)
ISSN:0014-5793, 1873-3468, 1873-3468
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Zusammenfassung:Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness. Hematopoietic stem cell (HSC) function declines during aging, leading to a higher risk of hematopoietic malignancies. By reverting protein ubiquitination, deubiquitinating enzymes (DUBs) ensure protein homeostasis, a key process in HSC maintenance. Here, we discuss how alterations in DUBs function exacerbate HSC aging, predisposing them to myelodysplastic syndrome and leukaemia. The potential of DUBs as therapeutic targets is highlighted.
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ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0014-5793
1873-3468
1873-3468
DOI:10.1002/1873-3468.14991