Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation

Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting p...

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Bibliographic Details
Published in:	FEBS letters Vol. 598; no. 22; pp. 2807 - 2808
Main Authors:	Citterio, Elisabetta, Ronchi, Antonella Ellena
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 01.11.2024
Subjects:	Acute Myeloid Leukemia (AML) Aging Aging - metabolism Aging - pathology Animals blood Cellular Senescence Deubiquitinases Deubiquitinating enzymes (DUBs) Deubiquitinating Enzymes - genetics Deubiquitinating Enzymes - metabolism elderly Graphical Review hematopoietic stem cells Hematopoietic Stem Cells (HSC) Hematopoietic Stem Cells - enzymology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Humans Myelodysplastic Syndromes (MDS) Myelodysplastic Syndromes - enzymology Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology Ubiquitination ubiquitinyl hydrolase 1 Hematopoietic Stem Cells (HSC) Ubiquitination Deubiquitinating enzymes (DUBs) Myelodysplastic Syndromes (MDS) Aging Deubiquitinases Acute Myeloid Leukemia (AML)
ISSN:	0014-5793, 1873-3468, 1873-3468
Online Access:	Get full text
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