Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation
Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting p...
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| Published in: | FEBS letters Vol. 598; no. 22; pp. 2807 - 2808 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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England
John Wiley and Sons Inc
01.11.2024
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| ISSN: | 0014-5793, 1873-3468, 1873-3468 |
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| Abstract | Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness.
Hematopoietic stem cell (HSC) function declines during aging, leading to a higher risk of hematopoietic malignancies. By reverting protein ubiquitination, deubiquitinating enzymes (DUBs) ensure protein homeostasis, a key process in HSC maintenance. Here, we discuss how alterations in DUBs function exacerbate HSC aging, predisposing them to myelodysplastic syndrome and leukaemia. The potential of DUBs as therapeutic targets is highlighted. |
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| AbstractList | Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness. Hematopoietic stem cell (HSC) function declines during aging, leading to a higher risk of hematopoietic malignancies. By reverting protein ubiquitination, deubiquitinating enzymes (DUBs) ensure protein homeostasis, a key process in HSC maintenance. Here, we discuss how alterations in DUBs function exacerbate HSC aging, predisposing them to myelodysplastic syndrome and leukaemia. The potential of DUBs as therapeutic targets is highlighted. Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness. Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness.Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness. Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness. image Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness. Hematopoietic stem cell (HSC) function declines during aging, leading to a higher risk of hematopoietic malignancies. By reverting protein ubiquitination, deubiquitinating enzymes (DUBs) ensure protein homeostasis, a key process in HSC maintenance. Here, we discuss how alterations in DUBs function exacerbate HSC aging, predisposing them to myelodysplastic syndrome and leukaemia. The potential of DUBs as therapeutic targets is highlighted. |
| Author | Ronchi, Antonella Ellena Citterio, Elisabetta |
| AuthorAffiliation | 1 Department of Biotechnology and Biosciences University of Milano‐Bicocca 20126 Milan Italy |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39108012$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/bjh.16549 10.1038/s41421-019-0092-z 10.1182/blood-2017-10-811760 10.1038/s41375-021-01394-z 10.1158/1535-7163.MCT-13-0103-T 10.3389/fimmu.2020.536442 10.1038/s41375-020-0878-x 10.1016/j.biocel.2023.106384 10.1038/s41375-021-01336-9 10.1038/s41580-019-0099-1 10.1084/jem.20132544 10.1038/s41419-021-03732-6 10.1016/j.jbc.2023.105055 10.1182/blood-2018-10-877563 10.1126/science.1221711 10.1038/s41568-020-0260-3 10.1084/jem.20131436 10.1038/s41467-020-20259-0 10.3390/ijms21083007 10.1016/j.cell.2023.01.020 10.1038/nrd.2017.152 10.1016/j.isci.2021.102435 10.1038/nchembio.2486 10.1093/hmg/ddaa189 10.1038/s41580-022-00543-1 10.1038/s41416-020-0731-z 10.1016/j.celrep.2020.108533 10.1038/s41568-023-00633-y 10.1126/sciimmunol.abq2061 10.1016/j.canlet.2019.03.046 10.1038/s41388-020-1253-0 10.1038/nature12530 10.1038/s41598-023-27486-7 10.1172/jci.insight.125690 10.1016/j.devcel.2009.01.001 |
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| Keywords | Hematopoietic Stem Cells (HSC) Ubiquitination Deubiquitinating enzymes (DUBs) Myelodysplastic Syndromes (MDS) Aging Deubiquitinases Acute Myeloid Leukemia (AML) |
| Language | English |
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| SubjectTerms | Acute Myeloid Leukemia (AML) Aging Aging - metabolism Aging - pathology Animals blood Cellular Senescence Deubiquitinases Deubiquitinating enzymes (DUBs) Deubiquitinating Enzymes - genetics Deubiquitinating Enzymes - metabolism elderly Graphical Review hematopoietic stem cells Hematopoietic Stem Cells (HSC) Hematopoietic Stem Cells - enzymology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Humans Myelodysplastic Syndromes (MDS) Myelodysplastic Syndromes - enzymology Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology Ubiquitination ubiquitinyl hydrolase 1 |
| Title | Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation |
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