Intergenerational and transgenerational epigenetic inheritance in animals

Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and e...

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Veröffentlicht in:	Nature cell biology Jg. 21; H. 2; S. 143 - 151
Hauptverfasser:	Perez, Marcos Francisco, Lehner, Ben
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.02.2019 Nature Publishing Group
Schlagworte:	631/136/2442 631/337/384 Animals Base sequence Biomedical and Life Sciences Cancer Research Cell Biology Deoxyribonucleic acid Developmental Biology Disease transmission DNA DNA Methylation DNA replication DNA sequencing Environment Epigenesis, Genetic Epigenetic inheritance Epigenetics Gametes Genetic research Genomics - methods Germ Cells - cytology Germ Cells - metabolism Heredity Inheritance Patterns - genetics Life Sciences Metabolites Models, Genetic Molecular genetics Molecular modelling Physiology Progeny Proteins Review Article Ribonucleic acid RNA Selection, Genetic Sperm Stem Cells
ISSN:	1465-7392, 1476-4679, 1476-4679
Online-Zugang:	Volltext
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Abstract	Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which ‘epigenetic’ information is transmitted between generations over different timescales, and the importance of this information for development and physiology. Perez and Lehner summarize recent discoveries regarding epigenetic inheritance across generations and review the molecular mechanisms underlying non-DNA sequence-based transmissions.
AbstractList	Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which 'epigenetic' information is transmitted between generations over different timescales, and the importance of this information for development and physiology. Perez and Lehner summarize recent discoveries regarding epigenetic inheritance across generations and review the molecular mechanisms underlying non-DNA sequence-based transmissions. Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which 'epigenetic' information is transmitted between generations over different timescales, and the importance of this information for development and physiology. Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which ‘epigenetic’ information is transmitted between generations over different timescales, and the importance of this information for development and physiology. Perez and Lehner summarize recent discoveries regarding epigenetic inheritance across generations and review the molecular mechanisms underlying non-DNA sequence-based transmissions. Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which 'epigenetic' information is transmitted between generations over different timescales, and the importance of this information for development and physiology.Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which 'epigenetic' information is transmitted between generations over different timescales, and the importance of this information for development and physiology.
Audience	Academic
Author	Lehner, Ben Perez, Marcos Francisco
Author_xml	– sequence: 1 givenname: Marcos Francisco surname: Perez fullname: Perez, Marcos Francisco organization: Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology – sequence: 2 givenname: Ben surname: Lehner fullname: Lehner, Ben email: ben.lehner@crg.eu organization: Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Universitat Pompeu Fabra (UPF), Institució Catalana de Recerca i Estudis Avançats (ICREA)
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30602724$$D View this record in MEDLINE/PubMed
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Snippet	Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what...
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SubjectTerms	631/136/2442 631/337/384 Animals Base sequence Biomedical and Life Sciences Cancer Research Cell Biology Deoxyribonucleic acid Developmental Biology Disease transmission DNA DNA Methylation DNA replication DNA sequencing Environment Epigenesis, Genetic Epigenetic inheritance Epigenetics Gametes Genetic research Genomics - methods Germ Cells - cytology Germ Cells - metabolism Heredity Inheritance Patterns - genetics Life Sciences Metabolites Models, Genetic Molecular genetics Molecular modelling Physiology Progeny Proteins Review Article Ribonucleic acid RNA Selection, Genetic Sperm Stem Cells
Title	Intergenerational and transgenerational epigenetic inheritance in animals
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