Germline Mutations in HOXB13 and Prostate-Cancer Risk

Prostate cancer runs in families. However, the genes that affect the incidence remain largely undefined. The authors have identified a rare germline variant of a homeobox gene, HOXB13, in four families with a history of prostate cancer. Prostate cancer is the most common noncutaneous cancer diagnose...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 366; no. 2; pp. 141 - 149
Main Authors:	Ewing, Charles M, Ray, Anna M, Lange, Ethan M, Zuhlke, Kimberly A, Robbins, Christiane M, Tembe, Waibhav D, Wiley, Kathleen E, Isaacs, Sarah D, Isaacs, William B, Johng, Dorhyun, Wang, Yunfei, Bizon, Chris, Yan, Guifang, Gielzak, Marta, Partin, Alan W, Shanmugam, Vijayalakshmi, Izatt, Tyler, Sinari, Shripad, Craig, David W, Zheng, S. Lilly, Walsh, Patrick C, Montie, James E, Xu, Jianfeng, Carpten, John D, Cooney, Kathleen A
Format:	Journal Article
Language:	English
Published:	Waltham, MA Massachusetts Medical Society 12.01.2012
Subjects:	Age Biological and medical sciences Chromosome 17 Chromosomes, Human, Pair 17 Deoxyribonucleic acid DNA DNA sequencing Genealogy General aspects Genetic Linkage Genetics Germ-Line Mutation Gynecology. Andrology. Obstetrics High-Throughput Nucleotide Sequencing Homeobox Homeodomain Proteins - genetics Humans Male Male genital diseases Medical research Medical sciences Men Middle Aged Mutation Nephrology. Urinary tract diseases Pedigree Prostate - pathology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Review boards Risk assessment Sequence Analysis, DNA Tumors Tumors of the urinary system Urinary tract. Prostate gland United States > US Michigan Medicine Urinary system disease Prostate disease Germ line Risk factor Genetics Risk Malignant tumor Mutation Male genital diseases Prostate cancer Cancer
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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