Germline Mutations in HOXB13 and Prostate-Cancer Risk

Prostate cancer runs in families. However, the genes that affect the incidence remain largely undefined. The authors have identified a rare germline variant of a homeobox gene, HOXB13, in four families with a history of prostate cancer. Prostate cancer is the most common noncutaneous cancer diagnose...

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Vydáno v:	The New England journal of medicine Ročník 366; číslo 2; s. 141 - 149
Hlavní autoři:	Ewing, Charles M, Ray, Anna M, Lange, Ethan M, Zuhlke, Kimberly A, Robbins, Christiane M, Tembe, Waibhav D, Wiley, Kathleen E, Isaacs, Sarah D, Isaacs, William B, Johng, Dorhyun, Wang, Yunfei, Bizon, Chris, Yan, Guifang, Gielzak, Marta, Partin, Alan W, Shanmugam, Vijayalakshmi, Izatt, Tyler, Sinari, Shripad, Craig, David W, Zheng, S. Lilly, Walsh, Patrick C, Montie, James E, Xu, Jianfeng, Carpten, John D, Cooney, Kathleen A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Waltham, MA Massachusetts Medical Society 12.01.2012
Témata:	Age Biological and medical sciences Chromosome 17 Chromosomes, Human, Pair 17 Deoxyribonucleic acid DNA DNA sequencing Genealogy General aspects Genetic Linkage Genetics Germ-Line Mutation Gynecology. Andrology. Obstetrics High-Throughput Nucleotide Sequencing Homeobox Homeodomain Proteins - genetics Humans Male Male genital diseases Medical research Medical sciences Men Middle Aged Mutation Nephrology. Urinary tract diseases Pedigree Prostate - pathology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Review boards Risk assessment Sequence Analysis, DNA Tumors Tumors of the urinary system Urinary tract. Prostate gland United States > US Michigan Medicine Urinary system disease Prostate disease Germ line Risk factor Genetics Risk Malignant tumor Mutation Male genital diseases Prostate cancer Cancer
ISSN:	0028-4793, 1533-4406, 1533-4406
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Prostate cancer runs in families. However, the genes that affect the incidence remain largely undefined. The authors have identified a rare germline variant of a homeobox gene, HOXB13, in four families with a history of prostate cancer. Prostate cancer is the most common noncutaneous cancer diagnosed in men in the United States, with more than 240,000 new cases expected in 2011. 1 Despite the demonstration of a strong familial component, identification of the genetic basis for hereditary prostate cancer has been challenging. Linkage studies of families with hereditary prostate cancer have provided inconsistent results. 2 In contrast, genomewide association studies have led to the identification of more than 30 single-nucleotide polymorphisms (SNPs) that are consistently associated with prostate cancer. 3 However, the magnitude of risk elevation attributed to each individual SNP is low, with an increased elevation in risk by . . .
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Mr. Ewing, Ms. Ray, and Dr. Lange and Drs. Isaacs and Cooney contributed equally to this article.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1110000