Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a disulfide-linked heterodimer with CD98 heavy chain (CD98hc, 4F2hc or SLC3A2), but the mechanism of assembly and amino ac...

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Veröffentlicht in:	Nature structural & molecular biology Jg. 26; H. 6; S. 510 - 517
Hauptverfasser:	Lee, Yongchan, Wiriyasermkul, Pattama, Jin, Chunhuan, Quan, Lili, Ohgaki, Ryuichi, Okuda, Suguru, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Oda, Kazumasa, Ishitani, Ryuichiro, Yokoyama, Takeshi, Nakane, Takanori, Shirouzu, Mikako, Endou, Hitoshi, Nagamori, Shushi, Kanai, Yoshikatsu, Nureki, Osamu
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Nature Publishing Group 01.06.2019
Schlagworte:	Amino acids Antibodies Assembly Brain Brain tumors Cholesterol Cryoelectron Microscopy Drug delivery Drug delivery systems Epitopes Fusion Regulatory Protein 1, Heavy Chain - chemistry Fusion Regulatory Protein 1, Heavy Chain - metabolism Fusion Regulatory Protein 1, Heavy Chain - ultrastructure Glycoproteins Humans Large Neutral Amino Acid-Transporter 1 - chemistry Large Neutral Amino Acid-Transporter 1 - metabolism Large Neutral Amino Acid-Transporter 1 - ultrastructure Models, Molecular Polysaccharides Protein Conformation Protein Folding Protein Multimerization
ISSN:	1545-9993, 1545-9985, 1545-9985
Online-Zugang:	Volltext
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