Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

The efficacy of tocilizumab was tested in a randomized, controlled trial involving patients with Covid-19 who had fever, pulmonary infiltrates, or a need for supplemental oxygen. The treatment had no significant effect on disease progression, independence from supplemental oxygen, or death.

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Podrobná bibliografie
Vydáno v:	The New England journal of medicine Ročník 383; číslo 24; s. 2333 - 2344
Hlavní autoři:	Stone, John H, Frigault, Matthew J, Serling-Boyd, Naomi J, Fernandes, Ana D, Harvey, Liam, Foulkes, Andrea S, Horick, Nora K, Healy, Brian C, Shah, Ruta, Bensaci, Ana Maria, Woolley, Ann E, Nikiforow, Sarah, Lin, Nina, Sagar, Manish, Schrager, Harry, Huckins, David S, Axelrod, Matthew, Pincus, Michael D, Fleisher, Jorge, Sacks, Chana A, Dougan, Michael, North, Crystal M, Halvorsen, Yuan-Di, Thurber, Tara K, Dagher, Zeina, Scherer, Allison, Wallwork, Rachel S, Kim, Arthur Y, Schoenfeld, Sara, Sen, Pritha, Neilan, Tomas G, Perugino, Cory A, Unizony, Sebastian H, Collier, Deborah S, Matza, Mark A, Yinh, Janeth M, Bowman, Kathryn A, Meyerowitz, Eric, Zafar, Amna, Drobni, Zsofia D, Bolster, Marcy B, Kohler, Minna, D’Silva, Kristin M, Dau, Jonathan, Lockwood, Megan M, Cubbison, Caroline, Weber, Brittany N, Mansour, Michael K
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Massachusetts Medical Society 10.12.2020
Témata:	Adult Age Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - therapeutic use Body temperature Body weight Boston Clinical trials Confidence intervals Coronaviridae Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - mortality Cytokines Death Disease Progression Double-Blind Method Double-blind studies Female Fever Humans Immunosuppressive agents Interleukin 6 Intubation Intubation - statistics & numerical data Male Mechanical ventilation Middle Aged Monoclonal antibodies Original Oxygen Patients Population Receptors, Interleukin-6 - antagonists & inhibitors Respiratory Therapy Severe acute respiratory syndrome coronavirus 2 Statistical analysis Treatment Failure Ventilators Young Adult Boston
ISSN:	0028-4793, 1533-4406, 1533-4406
On-line přístup:	Získat plný text
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Popis
Shrnutí:	The efficacy of tocilizumab was tested in a randomized, controlled trial involving patients with Covid-19 who had fever, pulmonary infiltrates, or a need for supplemental oxygen. The treatment had no significant effect on disease progression, independence from supplemental oxygen, or death.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 A complete list of the BACC Bay Tocilizumab Trial investigators and members of the data and safety monitoring board is provided in the Supplementary Appendix, available at NEJM.org.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2028836