Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination

The introduction of new rapid diagnostic tools for tuberculosis (TB) and the promising TB drugs pipeline together with the development of a new World Health Organization Strategy post 2015 allows new discussions on how to direct TB control. The European Respiratory Society's European Forum for...

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Bibliographic Details
Published in:	The European respiratory journal Vol. 42; no. 3; p. 785
Main Authors:	Diel, Roland, Loddenkemper, Robert, Zellweger, Jean-Pierre, Sotgiu, Giovanni, D'Ambrosio, Lia, Centis, Rosella, van der Werf, Marieke J, Dara, Masoud, Detjen, Anne, Gondrie, Peter, Reichman, Lee, Blasi, Francesco, Migliori, Giovanni Battista
Format:	Journal Article
Language:	English
Published:	England 01.09.2013
Subjects:	Antitubercular Agents - therapeutic use Communicable Disease Control - methods Disease Eradication - methods Humans Latent Tuberculosis - diagnosis Latent Tuberculosis - drug therapy Tuberculosis, Pulmonary - prevention & control
ISSN:	1399-3003, 1399-3003
Online Access:	Get more information
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Summary:	The introduction of new rapid diagnostic tools for tuberculosis (TB) and the promising TB drugs pipeline together with the development of a new World Health Organization Strategy post 2015 allows new discussions on how to direct TB control. The European Respiratory Society's European Forum for TB Innovation was created to stimulate discussion on how to best take advantage of old and new opportunities, and advances, to improve TB control and eventually progress towards the elimination of TB. While TB control is aimed at reducing the incidence of TB by early diagnosis and treatment of infectious cases of TB, TB elimination requires focus on sterilising the pool of latently infected individuals, from which future TB cases would be generated. This manuscript describes the three core components that are necessary to implement the elimination strategy fully. 1) Improve diagnosis of latent TB infected individuals. 2) Improve regimens to treat latent TB infection. 3) ensure public health commitment to make both 1) and 2) possible. Old and new evidence is critically described, focusing on the European commitment to reach elimination and on the innovative experiences and best practices available.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1399-3003 1399-3003
DOI:	10.1183/09031936.00205512