TP53 Gain-of-Function Mutation is a Poor Prognostic Factor in High-Methylated Metastatic Colorectal Cancer

Neither TP53 mutation nor DNA methylation status has been established as a biomarker alone of metastatic colorectal cancer. We analyzed the association between TP53 mutation functional subtypes and genome-wide DNA methylation status (GWMS) as combined prognostic markers. Patient clinical data were o...

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Bibliographic Details
Published in:	Clinical colorectal cancer Vol. 22; no. 3; pp. 327 - 338
Main Authors:	Wakayama, Shonosuke, Ouchi, Kota, Takahashi, Shin, Yamada, Yasuhide, Komatsu, Yoshito, Shimada, Ken, Yamaguchi, Tatsuro, Shirota, Hidekazu, Takahashi, Masanobu, Ishioka, Chikashi
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2023
Subjects:	DNA methylation TP53 mutation dMMR LMCC HMCC OS PTL IARC TP53 mutation MMR CRC mCRC CIMP GWMS DNA methylation Anti-EGFR Abs GOF
ISSN:	1533-0028, 1938-0674, 1938-0674
Online Access:	Get full text
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