Metastatic lobular carcinoma of the breast only in cystic lymph nodes, an incidental finding after laparoscopic cholecystectomy- A case report

Breast invasive lobular carcinoma (ILC) can metastasize to unusual sites due to a mutation in a cell-adhesion molecule called E-cadherin. The gastrointestinal tract (GI) and gallbladder (GB) are among these sites. Herein, we report a 62-year-old woman with a history of non-metastatic ILC who underwe...

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Bibliographic Details
Published in:Current problems in cancer. Case reports Vol. 19; p. 100382
Main Authors: Alipour, Sadaf, Eslami, Bita, Omranipour, Ramesh, Tavakol, Mahsa, Talebpour, Atieh
Format: Journal Article
Language:English
Published: Elsevier Inc 01.09.2025
Elsevier
Subjects:
Breast cancer
Cystic lymph node
Gallbladder
Hematology, Oncology, and Palliative Medicine
Invasive lobular carcinoma
Metastasis
Gallbladder
Breast cancer
Cystic lymph node
Metastasis
Invasive lobular carcinoma
ISSN:2666-6219, 2666-6219
Online Access:Get full text
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Summary:Breast invasive lobular carcinoma (ILC) can metastasize to unusual sites due to a mutation in a cell-adhesion molecule called E-cadherin. The gastrointestinal tract (GI) and gallbladder (GB) are among these sites. Herein, we report a 62-year-old woman with a history of non-metastatic ILC who underwent laparoscopic cholecystectomy five years after her breast cancer diagnosis because of episodes of biliary colic. Pathology results revealed metastasis originating from the breast in two cystic lymph nodes, with a normal gallbladder. After cholecystectomy, a PET-CT scan was performed for restaging, which showed no other sites of metastasis, and only some nonspecific uptakes were reported in the skeletal system. This case highlights the possibility of unusual GI metastasis in patients with a history of breast cancer, especially ILC with GI symptoms, even when imaging appears normal.
ISSN:2666-6219
2666-6219
DOI:10.1016/j.cpccr.2025.100382