Metastatic lobular carcinoma of the breast only in cystic lymph nodes, an incidental finding after laparoscopic cholecystectomy- A case report
Breast invasive lobular carcinoma (ILC) can metastasize to unusual sites due to a mutation in a cell-adhesion molecule called E-cadherin. The gastrointestinal tract (GI) and gallbladder (GB) are among these sites. Herein, we report a 62-year-old woman with a history of non-metastatic ILC who underwe...
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| Vydané v: | Current problems in cancer. Case reports Ročník 19; s. 100382 |
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| Hlavní autori: | , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Elsevier Inc
01.09.2025
Elsevier |
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| ISSN: | 2666-6219, 2666-6219 |
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| Abstract | Breast invasive lobular carcinoma (ILC) can metastasize to unusual sites due to a mutation in a cell-adhesion molecule called E-cadherin. The gastrointestinal tract (GI) and gallbladder (GB) are among these sites. Herein, we report a 62-year-old woman with a history of non-metastatic ILC who underwent laparoscopic cholecystectomy five years after her breast cancer diagnosis because of episodes of biliary colic. Pathology results revealed metastasis originating from the breast in two cystic lymph nodes, with a normal gallbladder. After cholecystectomy, a PET-CT scan was performed for restaging, which showed no other sites of metastasis, and only some nonspecific uptakes were reported in the skeletal system. This case highlights the possibility of unusual GI metastasis in patients with a history of breast cancer, especially ILC with GI symptoms, even when imaging appears normal. |
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| AbstractList | Breast invasive lobular carcinoma (ILC) can metastasize to unusual sites due to a mutation in a cell-adhesion molecule called E-cadherin. The gastrointestinal tract (GI) and gallbladder (GB) are among these sites. Herein, we report a 62-year-old woman with a history of non-metastatic ILC who underwent laparoscopic cholecystectomy five years after her breast cancer diagnosis because of episodes of biliary colic. Pathology results revealed metastasis originating from the breast in two cystic lymph nodes, with a normal gallbladder. After cholecystectomy, a PET-CT scan was performed for restaging, which showed no other sites of metastasis, and only some nonspecific uptakes were reported in the skeletal system. This case highlights the possibility of unusual GI metastasis in patients with a history of breast cancer, especially ILC with GI symptoms, even when imaging appears normal. AbstractBreast invasive lobular carcinoma (ILC) can metastasize to unusual sites due to a mutation in a cell-adhesion molecule called E-cadherin. The gastrointestinal tract (GI) and gallbladder (GB) are among these sites. Herein, we report a 62-year-old woman with a history of non-metastatic ILC who underwent laparoscopic cholecystectomy five years after her breast cancer diagnosis because of episodes of biliary colic. Pathology results revealed metastasis originating from the breast in two cystic lymph nodes, with a normal gallbladder. After cholecystectomy, a PET-CT scan was performed for restaging, which showed no other sites of metastasis, and only some nonspecific uptakes were reported in the skeletal system. This case highlights the possibility of unusual GI metastasis in patients with a history of breast cancer, especially ILC with GI symptoms, even when imaging appears normal. |
| ArticleNumber | 100382 |
| Author | Eslami, Bita Talebpour, Atieh Tavakol, Mahsa Omranipour, Ramesh Alipour, Sadaf |
| Author_xml | – sequence: 1 givenname: Sadaf surname: Alipour fullname: Alipour, Sadaf email: sadafalipour@yahoo.com organization: Breast Diseases Research Center (BDRC), Cancer Institute, Tehran university of Medical Sciences, Tehran, Iran – sequence: 2 givenname: Bita surname: Eslami fullname: Eslami, Bita email: dr.bes.96@gmail.com organization: Breast Diseases Research Center (BDRC), Cancer Institute, Tehran university of Medical Sciences, Tehran, Iran – sequence: 3 givenname: Ramesh surname: Omranipour fullname: Omranipour, Ramesh email: omranipour@tums.ac.ir organization: Breast Diseases Research Center (BDRC), Cancer Institute, Tehran university of Medical Sciences, Tehran, Iran – sequence: 4 givenname: Mahsa surname: Tavakol fullname: Tavakol, Mahsa email: mahsa.tavakol@gmail.com organization: Breast Diseases Research Center (BDRC), Cancer Institute, Tehran university of Medical Sciences, Tehran, Iran – sequence: 5 givenname: Atieh surname: Talebpour fullname: Talebpour, Atieh email: talebpouratieh@yahoo.com organization: Breast Diseases Research Center (BDRC), Cancer Institute, Tehran university of Medical Sciences, Tehran, Iran |
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| Cites_doi | 10.2478/amma-2023-0041 10.3390/cancers13123036 10.1016/j.ijscr.2021.01.106 10.11604/pamj.2014.17.216.3911 10.21037/tcr.2019.07.24 10.14701/ahbps.EP-153 |
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| Keywords | Gallbladder Breast cancer Cystic lymph node Metastasis Invasive lobular carcinoma |
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| SubjectTerms | Breast cancer Cystic lymph node Gallbladder Hematology, Oncology, and Palliative Medicine Invasive lobular carcinoma Metastasis |
| Title | Metastatic lobular carcinoma of the breast only in cystic lymph nodes, an incidental finding after laparoscopic cholecystectomy- A case report |
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