Overview of Epidemiology and Contribution of Obesity and Body Fat Distribution to Cardiovascular Disease: An Update

Obesity is recognized as a heterogeneous condition in which individuals with similar body mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to obesity-related cardiometabolic complications is not solely mediated by overall body fat mass, but is largely dependent...

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Bibliographic Details
Published in:Progress in cardiovascular diseases Vol. 61; no. 2; pp. 103 - 113
Main Authors: Piché, Marie-Eve, Poirier, Paul, Lemieux, Isabelle, Després, Jean-Pierre
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.07.2018
Subjects:
Bariatric surgery
Body fat distribution
Cardiovascular disease
Heart failure
Obesity
NSTEMI
T2DM
HTN
RV
MRI
Bariatric surgery
Cardiovascular disease
HR
LV
Body fat distribution
HFpEF
WC
HFrEF
BP
HDL
1H-MRS
LDL
VLDL
MI
BMI
WHO
WHR
Heart failure
Obesity
CAC
AF
CVD
CT
PA
AT
CV
DEXA
SCD
CRF
NHANES
FA
CHD
HF
LVH
ISSN:0033-0620, 1873-1740, 1532-8643, 1873-1740
Online Access:Get full text
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Summary:Obesity is recognized as a heterogeneous condition in which individuals with similar body mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to obesity-related cardiometabolic complications is not solely mediated by overall body fat mass, but is largely dependent upon individual differences in regional body fat distribution and ability of subcutaneous adipose tissue to expand. The present review will discuss to what extent the individual variation in body fat distribution is one of the clinical key variables explaining the metabolic heterogeneity of obesity and its related cardiovascular risk. We will present the evidence for the complex nature of the relationship between obesity and cardiovascular disease, outline our current understanding of the mechanisms involved, and identify future direction of research pertinent to this interaction.
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ISSN:0033-0620
1873-1740
1532-8643
1873-1740
DOI:10.1016/j.pcad.2018.06.004