Integration of Antiretroviral Therapy with Tuberculosis Treatment

In this study from South Africa, earlier initiation of antiretroviral therapy in patients with newly diagnosed HIV infection and TB was associated with higher rates of the immune reconstitution inflammatory syndrome and adverse events but increased AIDS-free survival. In patients who have infection...

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Veröffentlicht in:	The New England journal of medicine Jg. 365; H. 16; S. 1492 - 1501
Hauptverfasser:	Abdool Karim, Quarraisha, Abdool Karim, Salim S, Naidoo, Kogieleum, Naidoo, Anushka, Grobler, Anneke, Padayatchi, Nesri, Baxter, Cheryl, Gray, Andrew L, Gengiah, Tanuja, Gengiah, Santhanalakshmi, Jithoo, Niraksha, Nair, Gonasagrie, El-Sadr, Wafaa M, Friedland, Gerald
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Waltham, MA Massachusetts Medical Society 20.10.2011
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS AIDS-Related Opportunistic Infections - drug therapy Anti-Retroviral Agents - administration & dosage Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antitubercular Agents - therapeutic use Antiviral agents Bacilli Biological and medical sciences CD4 antigen CD4 Lymphocyte Count Death Disease-Free Survival Drug Administration Schedule Drug therapy Female General aspects HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - mortality Human immunodeficiency virus Human viral diseases Humans Immune reconstitution Immunosuppressive agents Infectious diseases Inflammation Kaplan-Meier Estimate Lymphocytes T Male Medical sciences Patients Pharmacology. Drug treatments Sputum Tuberculosis Tuberculosis - complications Tuberculosis - drug therapy Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load South Africa Immunopathology Antiretroviral agent Integration AIDS Mycobacterial infection Immune deficiency Infection Medicine Chemotherapy Treatment Tuberculosis Viral disease Bacteriosis Antiviral
ISSN:	0028-4793, 1533-4406, 1533-4406
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Zusammenfassung:	In this study from South Africa, earlier initiation of antiretroviral therapy in patients with newly diagnosed HIV infection and TB was associated with higher rates of the immune reconstitution inflammatory syndrome and adverse events but increased AIDS-free survival. In patients who have infection with the human immunodeficiency virus (HIV) and tuberculosis, antiretroviral therapy (ART) may be initiated at the same time as or soon after the initiation of tuberculosis treatment. However, antiretroviral agents are often deferred until after the intensive phase of tuberculosis treatment because of concern about the immune reconstitution inflammatory syndrome (IRIS), 1 , 2 a high pill burden, and overlapping side effects 3 when three antiretroviral agents are added to the standard four antituberculosis drugs. These challenges may result in interruption or discontinuation of treatment for the acquired immunodeficiency syndrome (AIDS) or tuberculosis, which can lead to drug . . .
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1014181