Hemophagocytic lymphohistiocytosis: An update on pathogenesis, diagnosis, and therapy

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or neoplastic triggers. Sustained, aberrant activation of cytotoxic CD8+ T cells and resultant inflammatory cytokine rele...

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Vydané v:	Best practice & research. Clinical rheumatology Ročník 34; číslo 4; s. 101515
Hlavní autori:	Griffin, Georgia, Shenoi, Susan, Hughes, Grant C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier Ltd 01.08.2020
Predmet:	CD8-Positive T-Lymphocytes Cytokines Glucocorticoids Hemophagocytic lymphohistiocytosis (HLH) Humans Lymphohistiocytosis, Hemophagocytic - diagnosis Lymphohistiocytosis, Hemophagocytic - etiology Lymphohistiocytosis, Hemophagocytic - therapy Macrophage activation syndrome (MAS) Macrophage Activation Syndrome - diagnosis Macrophage Activation Syndrome - etiology Macrophage Activation Syndrome - therapy Hemophagocytic lymphohistiocytosis (HLH) Macrophage activation syndrome (MAS)
ISSN:	1521-6942, 1532-1770, 1532-1770
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