Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

Autism spectrum disorder (ASD) is thought to emerge during early cortical development. However, the exact developmental stages and associated molecular networks that prime disease propensity are elusive. To profile early neurodevelopmental alterations in ASD with macrocephaly, we monitored subject-d...

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Veröffentlicht in:	Nature neuroscience Jg. 22; H. 2; S. 243 - 255
Hauptverfasser:	Schafer, Simon T, Paquola, Apua C M, Stern, Shani, Gosselin, David, Ku, Manching, Pena, Monique, Kuret, Thomas J M, Liyanage, Marvin, Mansour, Abed AlFatah, Jaeger, Baptiste N, Marchetto, Maria C, Glass, Christopher K, Mertens, Jerome, Gage, Fred H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Nature Publishing Group 01.02.2019
Schlagworte:	Autism Autism Spectrum Disorder - genetics Autism Spectrum Disorder - pathology Autism Spectrum Disorder - physiopathology Chromatin Cortex Developmental stages Direct conversion Gene Regulatory Networks Humans Induced Pluripotent Stem Cells - pathology Inhibitory postsynaptic potentials Inhibitory Postsynaptic Potentials - physiology Macrocephaly Nerve Net - physiopathology Neural stem cells Neural Stem Cells - pathology Neurons Neurons - pathology Neurons - physiology Phenotypes Pluripotency Priming Stem cells
ISSN:	1097-6256, 1546-1726, 1546-1726
Online-Zugang:	Volltext
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