Reply: Gut microbiome alterations in anti‐NMDA receptor encephalitis: caveats for result interpretation

[...]we stated in the “exclusion criteria” that all patients and healthy controls who had antibiotic or probiotic use within the past 3 months were excluded from our study. [...]a recently published study did not show any significant difference of gut microbiome between a small cohort of western pat...

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Bibliographic Details
Published in:Annals of clinical and translational neurology Vol. 7; no. 1; pp. 155 - 156
Main Authors: Gong, Xue, Liu, Xu, Li, Chen, Chen, Chu, Lin, Jingfang, Li, Aiqing, An, Dongmei, Zhou, Dong, Hong, Zhen
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01.01.2020
John Wiley and Sons Inc
Wiley
Subjects:
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Antibiotics
Digestive system
Encephalitis
Gastrointestinal Microbiome
Gut microbiota
Humans
Microbiota
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United States > US
Europe
ISSN:2328-9503, 2328-9503
Online Access:Get full text
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Summary:[...]we stated in the “exclusion criteria” that all patients and healthy controls who had antibiotic or probiotic use within the past 3 months were excluded from our study. [...]a recently published study did not show any significant difference of gut microbiome between a small cohort of western patients with anti‐NMDAR encephalitis and healthy control, although the effect of drugs on the gut microbiome could not be excluded in their study since some of the study subjects received immunesuppressives, neuroleptic medication, and probiotics. [...]future studies are needed to enroll more multicenter participants to understand the functional effects of the differences in the gut microbiota on disease initiation, aggravation, and progression.
Bibliography:These authors contributed equally.
This study was supported by the National Natural Science Foundation of China (grants 81971213, 81671291 and 81420108014) and National Key R&D Program of China (2018YFC1312300).
Funding Information
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ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.50969