Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ

Aims/hypothesis Subcutaneous immunisation with the 9-23 amino acid region of the insulin B chain (B:9-23) in incomplete Freund's adjuvant (IFA) can protect the majority of 4- to 6-week-old prediabetic NOD mice and is currently in clinical trials. Here we analysed the effect of B:9-23/IFA immuni...

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Bibliographic Details
Published in:	Diabetologia Vol. 53; no. 9; pp. 1958 - 1970
Main Authors:	Fousteri, G, Dave, A, Bot, A, Juntti, T, Omid, S, von Herrath, M
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.09.2010 Springer-Verlag Springer
Subjects:	B:9-23 Biological and medical sciences Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Human Physiology IFNγ IL-10 IL-4 Incomplete Freund's adjuvant insulin-dependent diabetes mellitus Internal Medicine Medical sciences Medicine Medicine & Public Health Metabolic Diseases Tregs IFNγ Incomplete Freund’s adjuvant Type 1 diabetes B:9-23 Tregs IL-4 IL-10 Endocrinopathy Immunopathology Pancreatic hormone Subcutaneous Cytokine Rodentia Autoimmune disease Insulin Vertebrata Interleukin 4 Mammalia Mouse Incomplete Freund's adjuvant Animal Adjuvant
ISSN:	0012-186X, 1432-0428
Online Access:	Get full text
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