Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties

The diabetic wound is easily to develop into a chronic wound because of the extremely serious and complex inflammatory microenvironment including biofilm formation, over-expressed reactive oxygen species (ROS), hypoxia and insufficiency of nitric oxide (NO) synthesis. In this work, a multifunctional...

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Vydané v:	Biomaterials Ročník 286; s. 121597
Hlavní autori:	Tu, Chenxi, Lu, Huidan, Zhou, Tong, Zhang, Wanying, Deng, Liwen, Cao, Wangbei, Yang, Zhijian, Wang, Zhaolong, Wu, Xinyu, Ding, Jie, Xu, Feng, Gao, Changyou
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier Ltd 01.07.2022
Predmet:	angiogenesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacterial quorum sensing biocompatible materials biofilm collagen crosslinking Diabetes Mellitus Diabetic wound epithelium Escherichia coli Humans hydrogels Hydrogels - chemistry hydrophilicity hypoxia Inflammation - drug therapy interleukin-10 interleukin-4 interleukin-6 macrophages Manganese Compounds - pharmacology manganese dioxide metabolism Methicillin-Resistant Staphylococcus aureus MnO2 nanosheet Multifunctional hydrogel nanosheets necrosis neoplasms neutrophils nitric oxide Nitric Oxide - pharmacology oxidative stress Oxides - pharmacology oxygen Oxygen - pharmacology pravastatin Pseudomonas aeruginosa reactive oxygen species Reactive Oxygen Species - pharmacology ROS-Scavenging secretion transcriptomics virulence Wound Infection Multifunctional hydrogel MnO2 nanosheet ROS-Scavenging Diabetic wound Bacterial quorum sensing MnO nanosheet
ISSN:	0142-9612, 1878-5905, 1878-5905
On-line prístup:	Získať plný text
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