Measles virus-induced immune suppression in the cotton rat (Sigmodon hispidus) model depends on viral glycoproteins

Immune suppression during measles accounts for most of the morbidity and mortality associated with the virus infection. Experimental study of this phenomenon has been hampered by the lack of a suitable animal model. We have used the cotton rat to demonstrate that mitogen-induced proliferation of spl...

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Published in:	Journal of virology Vol. 71; no. 10; p. 7214
Main Authors:	Niewiesk, S, Eisenhuth, I, Fooks, A, Clegg, J C, Schnorr, J J, Schneider-Schaulies, S, ter Meulen, V
Format:	Journal Article
Language:	English
Published:	United States 01.10.1997
Subjects:	Animals Cell Line Cells, Cultured Female Humans Immune Tolerance Kinetics Lymphocyte Activation Lymphocytes - immunology Lymphocytes - virology Male Measles - immunology Measles virus - immunology Measles virus - physiology Polymerase Chain Reaction Recombinant Proteins - biosynthesis RNA, Messenger - biosynthesis Sigmodontinae Spleen - immunology Spleen - virology Transcription, Genetic Transfection Viral Envelope Proteins - biosynthesis Virus Replication
ISSN:	0022-538X
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Abstract	Immune suppression during measles accounts for most of the morbidity and mortality associated with the virus infection. Experimental study of this phenomenon has been hampered by the lack of a suitable animal model. We have used the cotton rat to demonstrate that mitogen-induced proliferation of spleen cells from measles virus-infected animals is impaired. Proliferation inhibition is seen in all lymphocyte subsets and is not dependent on viral replication. Cells which express the viral glycoproteins (hemagglutinin and fusion protein) transiently by transfection induce proliferation inhibition after intraperitoneal inoculation, whereas application of a recombinant measles virus in which measles virus glycoproteins are replaced with the vesicular stomatitis virus G protein does not have an antiproliferative effect. Therefore, in vivo expression of measles virus glycoproteins is sufficient and necessary to induce inhibition of lymphocyte proliferation.
AbstractList	Immune suppression during measles accounts for most of the morbidity and mortality associated with the virus infection. Experimental study of this phenomenon has been hampered by the lack of a suitable animal model. We have used the cotton rat to demonstrate that mitogen-induced proliferation of spleen cells from measles virus-infected animals is impaired. Proliferation inhibition is seen in all lymphocyte subsets and is not dependent on viral replication. Cells which express the viral glycoproteins (hemagglutinin and fusion protein) transiently by transfection induce proliferation inhibition after intraperitoneal inoculation, whereas application of a recombinant measles virus in which measles virus glycoproteins are replaced with the vesicular stomatitis virus G protein does not have an antiproliferative effect. Therefore, in vivo expression of measles virus glycoproteins is sufficient and necessary to induce inhibition of lymphocyte proliferation.Immune suppression during measles accounts for most of the morbidity and mortality associated with the virus infection. Experimental study of this phenomenon has been hampered by the lack of a suitable animal model. We have used the cotton rat to demonstrate that mitogen-induced proliferation of spleen cells from measles virus-infected animals is impaired. Proliferation inhibition is seen in all lymphocyte subsets and is not dependent on viral replication. Cells which express the viral glycoproteins (hemagglutinin and fusion protein) transiently by transfection induce proliferation inhibition after intraperitoneal inoculation, whereas application of a recombinant measles virus in which measles virus glycoproteins are replaced with the vesicular stomatitis virus G protein does not have an antiproliferative effect. Therefore, in vivo expression of measles virus glycoproteins is sufficient and necessary to induce inhibition of lymphocyte proliferation. Immune suppression during measles accounts for most of the morbidity and mortality associated with the virus infection. Experimental study of this phenomenon has been hampered by the lack of a suitable animal model. We have used the cotton rat to demonstrate that mitogen-induced proliferation of spleen cells from measles virus-infected animals is impaired. Proliferation inhibition is seen in all lymphocyte subsets and is not dependent on viral replication. Cells which express the viral glycoproteins (hemagglutinin and fusion protein) transiently by transfection induce proliferation inhibition after intraperitoneal inoculation, whereas application of a recombinant measles virus in which measles virus glycoproteins are replaced with the vesicular stomatitis virus G protein does not have an antiproliferative effect. Therefore, in vivo expression of measles virus glycoproteins is sufficient and necessary to induce inhibition of lymphocyte proliferation.
Author	Eisenhuth, I Clegg, J C Schnorr, J J ter Meulen, V Fooks, A Niewiesk, S Schneider-Schaulies, S
Author_xml	– sequence: 1 givenname: S surname: Niewiesk fullname: Niewiesk, S organization: Institute of Virology and Immunobiology, University of Würzburg, Germany – sequence: 2 givenname: I surname: Eisenhuth fullname: Eisenhuth, I – sequence: 3 givenname: A surname: Fooks fullname: Fooks, A – sequence: 4 givenname: J C surname: Clegg fullname: Clegg, J C – sequence: 5 givenname: J J surname: Schnorr fullname: Schnorr, J J – sequence: 6 givenname: S surname: Schneider-Schaulies fullname: Schneider-Schaulies, S – sequence: 7 givenname: V surname: ter Meulen fullname: ter Meulen, V
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SubjectTerms	Animals Cell Line Cells, Cultured Female Humans Immune Tolerance Kinetics Lymphocyte Activation Lymphocytes - immunology Lymphocytes - virology Male Measles - immunology Measles virus - immunology Measles virus - physiology Polymerase Chain Reaction Recombinant Proteins - biosynthesis RNA, Messenger - biosynthesis Sigmodontinae Spleen - immunology Spleen - virology Transcription, Genetic Transfection Viral Envelope Proteins - biosynthesis Virus Replication
Title	Measles virus-induced immune suppression in the cotton rat (Sigmodon hispidus) model depends on viral glycoproteins
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